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Transplantation for retinal diseases

Research Project

Project/Area Number 14370553
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionTohoku University

Principal Investigator

ABE Toshiaki  Tohoku University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (90191858)

Co-Investigator(Kenkyū-buntansha) WADA Yuko  Tohoku University Hospital, Lecture, 病院・講師 (70302130)
TOMITA Hiroshi  Tohoku University, Graduate School of Medicine, Research associate, 大学院・医学系研究科, 助手 (40302088)
SATO Hajime  Tohoku University Hospital, Research associate, 病院・助手 (10312571)
YAMATO Masayuki  Tokyo Women's Medical University, Lecture, 医学部, 講師 (40267117)
OKANO Mitsuo  Tokyo Women's Medical University, Professor, 医学部, 教授 (00130237)
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2002: ¥7,400,000 (Direct Cost: ¥7,400,000)
Keywordsretinal pigment epithelium / iris pigment epithelium / brain derived-neurotrophic factor / adeno-associated virus / cell transplantation / TrkB / アデノアソシエイトウイルス / 免疫染色 / in situ hybridization / 網膜変性 / 光障害 / ウイルス至適濃度 / 神経保護因子 / バリアー / ウイルスベクター / 細胞増殖因子遺伝子 / 加齢黄斑変性 / 網膜色素変性 / 主要組織適合抗原
Research Abstract

We report a subretinal iris pigment epithelial cell (IPE) transplantation with safely. When these cells were genetically engineered that expressing neurotrophic factors, the transplantation rescued the photoreceptor cells from phototoxicity. We used adeno-associate virus (AAV2) for delivering neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) to the transplanted cells. If we used more than 1x107 capsides/ml AAV-BDNF for transfection, statistically significant photoreceptor protection was observed in the AAV-BDNF-IPE transplantation from phototoxicity. However, the rescue effect was not dose-dependent. Then, we examined the BDNF receptor TrkB expression, because the receptor may control the effect of BDNF. So far many isoforms of TrkB have reported and we examined two of the major isoforms of TrkB ; TrkB-FL which has tyrosine kinase activity in the cell and TrkB-T1 which has not. These isoforms showed not always completely same expression by immunohistochemistry. TrkB-FL was expressed mainly on nerve fiber layer, ganglion cells layer, and inner nuclear layer (INL), conversely TrkB-T1 was on INL and RPE. Both isoforms were not expressed in ONL and photoreceptor layer. From the results of double immunostaining with S100β, These isforms were expressed on Muller cells. Further these isoforms were expressed in the retina not only spatially but also temporally different way, although the expression was enhanced by the AAV-BDNF-IPE transplantation. When we performed in situ hybridization, same expression pattern were also confirmed. siRNA experiments showed significant less photoreceptor protection when we injected siRNA of TrkB-T1. When we examined differential gene expression by DNA microarray of Muller cell line, rMC-1 between BDNF stimulated and non-stimulated, neurotrophic factors that were so far reported were not many expressed. Another mechanism such as scavenging the ions in the surrounding circumstances may be important.

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (64 results)

All 2006 2005 2004 2003 2002 Other

All Journal Article (53 results) Publications (11 results)

  • [Journal Article] Hypothermia Protects Cultured Human Retinal Pigment Epithelial Cells against Trypan Blue Toxicity.2006

    • Author(s)
      Kunikata H, Abe T, et al.
    • Journal Title

      Ophthalmologica 220

      Pages: 114-117

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Hypothermia of 8°C Protects Cultured Retinal Pigment Epithelial Cells and Retinal Ganglion Cells against Trypan Blue Toxicity.2006

    • Author(s)
      Kunikata H, Abe T, et al.
    • Journal Title

      Am J Ophthalmol 141

      Pages: 754-756

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A case of Fukuyama-type congenital muscular dystrophy with a very mild mental deficit.2006

    • Author(s)
      Hino-Fukuyo N, Abe T, et al.
    • Journal Title

      Neuromuscul Disord. 16

      Pages: 274-6

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Recombinant AAV-transduced Iris Pigment Epithelial Cells Transplantation May Transfer Vector to Native RPE but Suppress Systemic Dissemination.2006

    • Author(s)
      Yoshioka Y, Abe T, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci 47

      Pages: 745-752

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Hypothermia Protects Cultured Human Retinal Pigment Epithelial Cells against Trypan Blue Toxicity.2006

    • Author(s)
      Kunikata H, Tomita, H, Murata H, Sagara Y, Sato H, Wada Y, Fuse N, Nakagawa Y, Abe T, Tamai M.
    • Journal Title

      Ophthalmologica. 220

      Pages: 114-117

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Hypothermia of 8℃ Protects Cultured Retinal Pigment Epithelial Cells and Retinal Ganglion Cells against Trypan Blue Toxicity.2006

    • Author(s)
      Kunikata H, Abe T, Murata H, Sagara Y, Wakusawa R, Yoshida H, Yoshida M, Fuse N, Tamai M.
    • Journal Title

      Am J Ophthalmol. 141

      Pages: 754-756

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A case of Fukuyama-type congenital muscular dystrophy with a very mild mental deficit.2006

    • Author(s)
      Hino-Fukuyo N, Haginoya K, Hayashi YK, Nishino I, Murakami T, Nonaka I, Togashi K, Tanaka S, Takayanagi M, Yokoyama H, Sakamoto O, Abe T, Toda T, Iinuma K.
    • Journal Title

      Neuromuscul Disord. 16

      Pages: 274-276

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Recombinant AAV-transduced Iris Pigment Epithelial Cells Transplantation May transfer Vector to Native RPE but Suppress Syntemic Dissemination2006

    • Author(s)
      Yoshioka Y, Abe T, Wakusawa R, Moriya T, Mochizuki S, Saigo Y, Saito T, Murata Y, Tokita Y, Iseya T, Sugano E, Tomita H, Sagara Y, Tamai M
    • Journal Title

      Invest Ophthalmol Vis Sci 47

      Pages: 745-752

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Recombinant AAV-Transduced Iris Pigment Epithelial Cell Transplantation May Transfer Vector to Native RPE but Suppress Systemic Dissemination.2006

    • Author(s)
      Yoshioka Y, Abe T, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci. 47

      Pages: 745-752

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Protection of Photoreceptor Cells from Phototoxicity by Transplanted Retinal Pigment Epithelial Cells Expressing Different Neurotrophic Factors.2005

    • Author(s)
      Abe T, Saigo Y, Hojo M, Kano T, Wakusawa R, Tamai M.
    • Journal Title

      Cell Transplant 14

      Pages: 799-808

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 加齢黄斑変性とポリープ状脈絡膜血管症に対するトリアムシノロンテノン嚢下注射の短期的効果2005

    • Author(s)
      涌沢亮介, 吉田まどか, 阿部俊明, 吉田光, 玉井信
    • Journal Title

      眼科臨床医報 99

      Pages: 808-811

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chemokine profile in the cerebrospinal fluid and serum of Vogt-Koyanagi-Harada Disease.2005

    • Author(s)
      Miyazawa I, Abe T, et al.
    • Journal Title

      J Neuroimmunol 158

      Pages: 240-244

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Protection of Photoreceptor Cells from Phototoxicity by Transplanted Retinal Pigment Epithelial Cells Expressing Different Neurotrophic Factors.2005

    • Author(s)
      Abe T, Saigo Y, Hojo M, Kano T, Wakusawa R, Tamai, M.
    • Journal Title

      Cell Transplant 14

      Pages: 799-808

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sub-tenon injection of triamcinolone acetonide for age-related macular degeneration and polypoidal choroidal vasculopathy : short-term results.2005

    • Author(s)
      Wakusawa R, Yoshida M, Abe T, Yoshida H, Tamai M.
    • Journal Title

      Ganka Rinsyou Ihou 99

      Pages: 808-811

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chemokine profile in the cerebrospinal fluid and serum of Vogt-Koyanagi-Harada Disease.2005

    • Author(s)
      Miyazawa I, Abe T, Narikawa K, Feng J, Misu T, Nakashima I, Fujimori J, Tamai M, Fujihara K, Itoyama Y.
    • Journal Title

      J Neuroimmunol. 158

      Pages: 240-244

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Protection of photoreceptor cells from phototoxicity by transplanted retinal pigment epithelial cells expressing different neurotrophic factors.2005

    • Author(s)
      Abe T, Saigo Y, Hojo M, Kano T, Wakusawa R, Tokita Y, Tamai M.
    • Journal Title

      Cell Transplant. 14

      Pages: 799-808

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Establishment of effective methods for transducing genes into iris pigment epithelial cells by using adeno-associated virus type 2.2005

    • Author(s)
      Sugano E, Tomita H, Ishiguro S, Abe T, Tamai M.
    • Journal Title

      Invest Ophthalmol Vis Sci. 46

      Pages: 3341-3348

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Chemokine profile in the cerebrospinal fluid and serum of Vogt-Koyanagi-Harada disease.2005

    • Author(s)
      Miyazawa I, Abe T, et al.
    • Journal Title

      J Neuroimmunol 158

      Pages: 240-244

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 遺伝子導入による細胞工学と治療への応用2005

    • Author(s)
      阿部俊明
    • Journal Title

      臨床眼科 59

      Pages: 256-260

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 再生医療-加齢黄斑変性をにらんで2005

    • Author(s)
      阿部俊明
    • Journal Title

      臨床眼科 59

      Pages: 1819-1822

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Chemokine profile in the cerebrospinal fluid and serum of Vogt-Koyanagi-Harada2005

    • Author(s)
      I Miyazawa, T Abe, K Narikawa, J Feng, T Misu, I Nakashima, J Fujimori, M Tamai, K Fujihara, Y Itoyama
    • Journal Title

      J Neuroimmunol 158

      Pages: 240-244

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Transplantation of transduced retinal pigment epithelium in rats.2004

    • Author(s)
      Saigo Y, Abe T, et al.
    • Journal Title

      Invest Ophthalmol Vis Sc 45

      Pages: 1996-2004

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Photoreceptor Protection by Iris Pigment Epithelial Transplantation Transduced with AAV-Mediated Brain-Derived Neurotrophic Factor Gene.2004

    • Author(s)
      Hojo M, Abe T, Sugano E, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci 45

      Pages: 3721-3726

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Branch retinal artery occlusion : a complication of iron-deficiency anemia in a young adult with a rectal carcinoid.2004

    • Author(s)
      Imai E, Kunikata H, Udono T, Nakagawa Y, Abe T, Tamai M.
    • Journal Title

      Tohoku J Exp Med. 203

      Pages: 141-144

    • NAID

      10013091421

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transplantation of transduced retinal pigment epithelium in rats.2004

    • Author(s)
      Seigo Y, Abe T, Hojo M, Tomita H, Sugano E, Tamai M.
    • Journal Title

      Invest Ophthalmol Vis Sci. 45

      Pages: 1996-2004

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Photoreceptor Protection by Iris Pigment Epithelial Transplantation Transduced with AAV-Mediated Brain-Derived Neurotrophic Factor Gene.2004

    • Author(s)
      Hojo M, Abe T, Sugano E, Yoshioka Y, Saigo Y, Tomita H, Wakusawa R, Tamai M.
    • Journal Title

      Invest Ophthalmol Vis Sci. 45

      Pages: 3721-3726

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Photoreceptor Protection by Iris Pigment Epithelial Transplantation Transduced with AAV-Mediated Brain-Derived Neurotrophic Factor Gene.2004

    • Author(s)
      Hojo M, Abe T, Sugano E, Yoshioka Y, Saigo Y, Tomita H, Wakusawa R, Tamai
    • Journal Title

      Invest Ophthalmol Vis Sci. 45

      Pages: 3721-3726

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Transplantation of transduced retinal pigment epithelium in rats.2004

    • Author(s)
      Saigo Y, Abe T, Hojo M, Tomita H, Sugano E, Tamai M
    • Journal Title

      Invest Ophthalmol Vis Sci. 45

      Pages: 1996-2004

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Branch retinal artery occlusion : a complication of iron-deficiency anemia in a young adult with a rectal carcinoid2004

    • Author(s)
      Imai E, Kunikata H, Udono T, Nakagawa Y, Abe T, Tamai M.
    • Journal Title

      Tohoku J Exp Med. 203

      Pages: 141-144

    • NAID

      10013091421

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Interleukin-1β is Associated with Alteration of Barrier Function of Retinal Pigment Epithelial Cells(ARPE-19) by Aberrant Expression of Junctional Complex Molecules.2003

    • Author(s)
      Abe T, Sugano E, Saigo Y, Tamai M.
    • Journal Title

      Invest Ophthalmol Vis Sci 44

      Pages: 4097-4104

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Interferon Gamma Expression and Clinical Features in Patients with Acute Retinal Necrosis Syndrome.2003

    • Author(s)
      Abe T, Sato M, Saigo Y, Tamai M.
    • Journal Title

      Graefe's Arch Clin Exp Ophthalmol 241

      Pages: 982-987

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Comparative study of cathepsins D and S in rat IPE and RPE cells.2003

    • Author(s)
      Sugano E, Abe T, et al.
    • Journal Title

      Exp Eye Res. 77

      Pages: 203-209

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Autosomal dominant macular degeneration associated with 208delG mutation in the FSCN2 gene.2003

    • Author(s)
      Wada Y, Abe T, et al.
    • Journal Title

      Arch Ophthalmol. 2003 121

      Pages: 1613-1620

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Regeneration of the retina using pigment epithelial cell transplantation : A review.2003

    • Author(s)
      Abe T.
    • Journal Title

      Jpn J Ophthalmol 47

      Pages: 322-323

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transgenic rd mice harboring axokine gene by Rpe65 gene promoter does not rescue photoreceptor degeneration.2003

    • Author(s)
      Abe T, Yoshioka Y, et al.
    • Journal Title

      Adv Exp Med Biol. 533

      Pages: 403-406

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Comparative study of cathepsin D and S in rat IPE and RPE cells.2003

    • Author(s)
      Tomita H, Abe T, et al.
    • Journal Title

      Adv Exp Med Biol. 533

      Pages: 343-346

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Interleukin-1β is Associated with Alteration of Barrier Function of Retinal Pigment epithelial Cells (ARPE-19) by Aberrant Expression of Junctional Complex Molecules.2003

    • Author(s)
      Abe T, Sugano E, Saigo Y, Tamai M.
    • Journal Title

      Invest Ophthalmol Vis Sci 44

      Pages: 4097-4104

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Interferon Gamma Expression and Clinical Features in Patients with Acute Retinal Necrosis Syndrome.2003

    • Author(s)
      Abe T, Sato M, Saigo Y, Tamai M
    • Journal Title

      Graefe's Arch Clin Exp Ophthalmol 241

      Pages: 982-987

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Comparative study of cathepsins D and S in rat IPE and RPE cells.2003

    • Author(s)
      Sugano E, Tomita H, Abe T, Yamashita A, Tamai M
    • Journal Title

      Exp Eye Res. 77

      Pages: 203-209

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Autosomal dominant macular degeneration associated with 208delG mutation in the FSCN2 gene.2003

    • Author(s)
      Wada Y, Abe T, Itabashi T, Sato H, Kawamura M, Tamai M.
    • Journal Title

      Arch Ophthalmol.2003 121

      Pages: 1613-1620

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transgenic rd mice harboring axokine gene by Rpe65 gene promoter does not rescue photoreceptor degeneration.2003

    • Author(s)
      Abe T, Yoshioka Y, Tomita H, Saigo Y, Udono T, Shibahara S, Tamai M.
    • Journal Title

      Adv Exp Med Biol. 533

      Pages: 403-406

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Comparative study of cathepsin D and S in rat IPE and RPE cells.2003

    • Author(s)
      Tomita H, Sugano E, Abe T, Yamashita A, Tamai M.
    • Journal Title

      Adv Exp Med Biol. 533

      Pages: 343-346

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Two types of optical coherence tomographic images of retinal pigment epithelial detachments with different prognosis.2002

    • Author(s)
      Yoshida M, Abe T, Kano T, Tamai T.
    • Journal Title

      Br.J.Ophthalmol. 86

      Pages: 737-739

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Elevated Adrenomedullin Levels in the Aqueous Humor of Patients with Uveitis and Vitreoretinal Disorders.2002

    • Author(s)
      Udono T, Takahashi K, Abe T, Shibahara S, Tamai M.
    • Journal Title

      Peptides 23

      Pages: 1865-1868

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Protective effect of iris pigment epithelial cells transfected BDNF gene from ischemia and light damage2002

    • Author(s)
      Kano T, Abe T, Tomita H, Sakata T, Ishiguro S, Tamai M.
    • Journal Title

      Invest Ophthalmol Vis Sci 43

      Pages: 3744-3753

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Nipradilol inhibits apoptosis by preventing the activation of caspase-3 via S-nitrosylation and the cGMP-dependent pathway.2002

    • Author(s)
      Tomita H, Nakazawa T, Sugano E, Abe T, Tamai M.
    • Journal Title

      Eur J Pharmacol. 11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 網膜色素変性に伴う嚢胞様黄斑浮腫と硝子体手術。2002

    • Author(s)
      玉井洋, 和田裕子, 阿部俊明, 玉井信
    • Journal Title

      臨眼 56

      Pages: 1443-1446

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 眼の再生医学。色素上皮細胞を利用した網膜再生医療の可能性。(宿題報告)2002

    • Author(s)
      阿部俊明
    • Journal Title

      日本眼科学会雑誌 106

      Pages: 778-804

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Two types of optical coherence tomographic images of retinal pigment epithelial detachments with different prognosis.2002

    • Author(s)
      Yoshida M, Abe T, Kano T, Tamai M.
    • Journal Title

      Br.J.Ophthalmol. 86

      Pages: 737-739

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Protective effect of iris pigment epithelial cells transfected BDNF gene from ischemia and light damage2002

    • Author(s)
      Kano T, Abe T, Tomita H, Sakata T, Ishiguro S, Tamai M
    • Journal Title

      Invest Ophthalmol Vis Sci 43

      Pages: 3744-3753

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Nipradilol inhibits apoptosis by preventing the activation of caspase-3 via S-nitrosylation and the cGMP-dependent pathway.2002

    • Author(s)
      Tomita H, Nakazawa T, Sugano E, Abe T, Tamai M.
    • Journal Title

      Eur J Pharmacol. 11 ; 452

      Pages: 263-263

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Vitreous surgery for cystoid macular edema in a case of retinitis pigmentosa.2002

    • Author(s)
      Tamai H, Wada Y, Abe T, Tamai M.
    • Journal Title

      Rinsyou Ganka 56

      Pages: 1443-1446

    • NAID

      40019976252

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Regeneration of the Retina Using Pigment Epithelial Cell Transplantation.2002

    • Author(s)
      Abe T.
    • Journal Title

      Journal of Japanese Ophthalmological Society 106

      Pages: 778-804

    • NAID

      10010602762

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
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  • [Publications] Abe T, Sugano E, Saigo Y, Tamai M.: "Interleukin-1β is Associated with Alteration of Barrier Function of Retinal Pigment Epithelial Cells (ARPE-19) by Aberra"Invest Ophthalmol Vis Sci. 44. 4097-4104 (2003)

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  • [Publications] Abe T, Sato M, Saigo Y, Tamai M.: "Interferon Gamma Expression and Clinical Features in Patients with Acute Retinal Necrosis Syndrome"Graefe's Arch Clin Exp Ophthalmol. 241. 982-987 (2003)

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  • [Publications] Udono T, Abe T, Tamai M.: "Bilateral Central Retinal Artery Occlusion in Churg-Strauss Syndrome"Am J Ophthalmol. 136. 1181-1183 (2003)

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  • [Publications] Sugano E, Tomita H, Abe T, Yamashita A, Tamai M.: "Comparative study of cathepsins D and S in rat IPE and RPE cells"Exp Eye Res. 77. 203-209 (2003)

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  • [Publications] Wada Y, Abe T, Itabashi T, Sato H, Kawamura M, Tamai M.: "Autosomal dominant macular degeneration associated with 208delG mutation in the ESCN2 gene"Arch Ophthalmol. 121. 1613-1620 (2003)

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  • [Publications] 阿部俊明: "眼の再生医学 色素上皮細胞を利用した網膜再生医療の可能性。宿題報告III"日本眼科学会雑誌. 106. 778-804 (2002)

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  • [Publications] 阿部俊明, 玉井信: "網膜・視神経の発生と再生「加齢黄斑変性への虹彩色素上皮細胞の移植」"Molecular Medicine 別冊. 39. 241-248 (2002)

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  • [Publications] 阿部俊明: "網膜の再生。1.色素上皮細胞移植による網膜再生"眼科診療プラクテイス 眼の再生医学. 91. 114-119 (2002)

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  • [Publications] Kano T, Abe T, Tomita H, Sakata T, Ishiguro S, Tamai M.: "Protective effect of iris pigment epithelial cells transfected BDNF gene from ischemia and light damage"Invest Ophthalmol Vis. Sci.. 43. 3744-3753 (2002)

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  • [Publications] Sato H, Wada Y, Abe T, Kawamura M, Wakusawa R.: "Clinicopathologic Reports, Case Reports, and Small Case Series : Retinitis Pigmentosa Associated With Ectopia Lentis"Arch Ophthalmol. 120. 852-854 (2002)

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  • [Publications] Yoshida M, Abe T, Kano T, Tamai M.: "Two types of optical coherence tomographic images of retinal pigment epithelial detachments with different prognosis"Br. J. Ophthalmol.. 86. 737-739 (2002)

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Published: 2002-04-01   Modified: 2016-04-21  

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