| Project/Area Number |
14370561
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kumamoto University |
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Principal Investigator |
TANIHARA Hidenobu Kumamoto University, Graduate School of Medical Sciences, Ophthalmogy and visual science, Professor, 大学院・医学薬学研究部, 教授 (60217148)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Mikiko Kumamoto University, Kumamoto University Hospital, Ophthalmogy, Assistant, 医学部附属病院, 助手 (10284770)
HIRATA Akira Kumamoto University, Kumamoto University Hospital, Ophthalmogy, Instructor, 医学部附属病院, 講師 (60295144)
木村 章 熊本大学, 医学部附属病院, 講師 (20284771)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥14,900,000 (Direct Cost: ¥14,900,000)
Fiscal Year 2003: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 2002: ¥9,400,000 (Direct Cost: ¥9,400,000)
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| Keywords | glaucoma / neuroprotection / cytokine / statin / antithrombin III / familial amyloid polyneuropathy / endogenous survival factor / SEREX法 |
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| Research Abstract |
In this research, we investigated our hypothesis that immune reaction and stress response exerted neuroprotective effect on glaucomatous optic nerve damage. First, we reported that IL-6, multifunctional cytokine produced by several cells, provided a neuroproctive effect on retinal damage (BBRC 302:226,2003). Second, we demonstrated the neuroprotective effect of statin (Arch Ophthalmol 120:1707,2002) and antithrombin III (IOVS 44:332,2003) and the beneficial effects of anti-LOX-1 antibody on the endotoxin-induced inflammation (Pro Natl Acad Sci USA 100:1274,2003) by inhibiting leukocyte-endothelial interaction. Third, we demonstrated the neuroprotective effect of LEDGF, enodogenous and exogenous survival factor, on retinal damage (Brain Res 991:163,2003). Fourth, we elucidated the clinical and surgical outcomes of the treatment of unique type of secondary glaucoma associated with transthyretin related familial amyliod polyneuropathy (Arch Ophthalmol 121:351,2003).
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