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A research about the new therapy for glaucomatous optic nerve damage based on the endogenous neuroprotective system

Research Project

Project/Area Number 14370561
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionKumamoto University

Principal Investigator

TANIHARA Hidenobu  Kumamoto University, Graduate School of Medical Sciences, Ophthalmogy and visual science, Professor, 大学院・医学薬学研究部, 教授 (60217148)

Co-Investigator(Kenkyū-buntansha) FUKUSHIMA Mikiko  Kumamoto University, Kumamoto University Hospital, Ophthalmogy, Assistant, 医学部附属病院, 助手 (10284770)
HIRATA Akira  Kumamoto University, Kumamoto University Hospital, Ophthalmogy, Instructor, 医学部附属病院, 講師 (60295144)
木村 章  熊本大学, 医学部附属病院, 講師 (20284771)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥14,900,000 (Direct Cost: ¥14,900,000)
Fiscal Year 2003: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 2002: ¥9,400,000 (Direct Cost: ¥9,400,000)
Keywordsglaucoma / neuroprotection / cytokine / statin / antithrombin III / familial amyloid polyneuropathy / endogenous survival factor / SEREX法
Research Abstract

In this research, we investigated our hypothesis that immune reaction and stress response exerted neuroprotective effect on glaucomatous optic nerve damage. First, we reported that IL-6, multifunctional cytokine produced by several cells, provided a neuroproctive effect on retinal damage (BBRC 302:226,2003). Second, we demonstrated the neuroprotective effect of statin (Arch Ophthalmol 120:1707,2002) and antithrombin III (IOVS 44:332,2003) and the beneficial effects of anti-LOX-1 antibody on the endotoxin-induced inflammation (Pro Natl Acad Sci USA 100:1274,2003) by inhibiting leukocyte-endothelial interaction. Third, we demonstrated the neuroprotective effect of LEDGF, enodogenous and exogenous survival factor, on retinal damage (Brain Res 991:163,2003). Fourth, we elucidated the clinical and surgical outcomes of the treatment of unique type of secondary glaucoma associated with transthyretin related familial amyliod polyneuropathy (Arch Ophthalmol 121:351,2003).

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Inomata Y, Hirata A, Yonemura N, Koga T, Kido N, Tanihara H.: "Neuroprotective effects of interleukin-6 on NMDA-induced rat retinal damage."Biochem.Biophys.Res.Commun.. 302. 226-232 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Inomata Y, Hirata A, Koga T, Kimura A, Singh DP, Shinohara T, Tanihara H.: "Lens epithelium-derived growth factor : neuroprotection on rat retinal damage induced by N-methyl-D-aspartate."Brain Research. 991. 163-170 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Honjo M, Tanihara H, Nishijima K, Kiryu J, Honda Y, Yue BY, Sawamura T.: "Statin inhibits leukocyte-endothelial interaction and prevents neuronal death induced by ischemia-reperfusion injury in the rat retina."Arch.Ophthalmol.. 120. 1707-1713 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishijima K, Kiryu J, Tsujikawa A, Honjo M, Nonaka A, Yamashiro K, Kamizuru H, Ieki Y, Tanihara H, Honda Y, Ogura Y.: "Inhibitory effects of antithrombin III on interactions between blood cells and endothelial cells during retinal ischemia-reperfusion injury."Invest.Ophthalmol.Vis.Sci.. 44. 332-341 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Honjo M, Nakamura K, Yamashiro K, Kiryu J, Tanihara H, McEvoy LM, Honda Y, Butcher EC, Masaki T, Sawamura T.: "Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation."Proc Natl Acad Sci USA. 100. 1274-1279 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kimura A, Ando E, Fukushima M, Koga T, Hirata A, Arimura K, Ando Y, Negi A, Tanihara H.: "Secondary glaucoma in patients with familial amyloidotic polyneuropathy."Arch.Ophthalmol.. 121. 351-356 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Inomata Y, et al.: "Neuroprotective effects of interleukin-6 on NMDA-induced rat retinal damage."Biochem.Biophys.Res.Commun.. 302. 226-232 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Inomata Y, et al.: "Lens epithelium-derived growth factor : neuroprotection on rat retinal damage induced by N-methyl-D-aspartate."Brain Research. 991. 163-170 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Honjo M, et al.: "Statin inhibits leukocyte-endothelial interaction and prevents neuronal death induced by ischemia-reperfusion injury in the rat retina."Arch.Ophthalmol.. 120. 1707-1713 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishijima K, et al.: "Inhibitory effects of antithrombin III on interactions between blood cells and endothelial cells during retinal ischemia-reperfusion injury."Invest.Ophthalmol.Vis.Sci.. 44. 332-341 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Honjo M, et al.: "Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation."Proc Natl Acad Sci USA. 100. 1274-1279 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kimura A, et al.: "Secondary glaucoma in patients with familial amyloidotic polyneuropathy."Arch.Ophthalmol.. 121. 351-356 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Inomata Y, Hirata A, Yonemura N, Koga T, Kido N, Tanihara H: "Neuroprotective effects of interleukin-6 on NMDA-induced rat retinal damage"Biochem.Biophys.Res.Commun.. 302・2. 226-232 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Inomata Y, Hirata A, Koga T, Kimura A, Singh DP, Shinohara T, Tanihara H: "Lens epithelium-derived growth factor : neuroprotection on rat retinal damage induced by N-methyl-D-aspartate"Brain Research. 991・1-2. 163-170 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Honjo M, Tanihara H, Nishijima K, Kiryu J, Honda Y, Yue BY, Sawamura T: "Statin inhibits leukocyte-endothelial interaction and prevents neuronal death induced by ischemia-reperfusion injury in the rat retina"Arch.Ophthalmol.. 120・12. 1707-1713 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nishijima K, Kiryu J, Tsujikawa A, Honjo M, Nonaka A, Yamashiro K, Kamizuru H, Ieki Y, Tanihara H, Honda Y, Ogura Y: "Inhibitory effects of antithrombin III on interactions between blood cells and endothelial cells during retinal ischemia-reperfusion injury"Invest.Ophthalmol.Vis.Sci.. 44・1. 332-341 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Honjo M, Nakamura K, Yamashiro K, Kiryu J, Tanihara H, McEvoy LM, Honda Y, Butcher EC, Masaki T, Sawamura, T: "Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation"Proc Natl Acad Sci U S A. 100・3. 1274-1279 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kimura A, Ando E, Fukushima M, Koga T, Hirata A, Arimura K, Ando Y, Negi A, Tanihara H: "Secondary glaucoma in patients with familial amyloidotic polyneuropathy"Arch.Ophthalmol.. 121・3. 351-356 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Inomata Y, Hirata A, Yonemura N, Koga T, Kido N, Tanihara H: "Neuroprotective effects of interleukin-6 on NMDA-induced rat retinal damage"Biochem Biophys Res Commun. 302(2). 226-232 (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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