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Establishment of the method to explore neural interaction between the sacrum and anorectum using a repetitive magnetic stimulation in children

Research Project

Project/Area Number 14370566
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionNiigata University

Principal Investigator

KUBOTA Masayuki  Niigata University, Institute of Medicine and Dentistry, Professor, 医歯学系, 教授 (50205150)

Co-Investigator(Kenkyū-buntansha) YAGI Minoru  Kurume University, Hospital, Professor, 医学部附属病院, 教授 (10251802)
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥10,100,000 (Direct Cost: ¥10,100,000)
Keywordsmagnetic stimulation / repetitive magnetic stimulation / Anorectal reflex / sacral nerve / sacro-rectal interaction / Hirschsnrung's disease / chronic constipation / anorectal manometry / 仙骨神経機能 / 仙骨大腸機能連関 / 直腸肛門内圧 / 恥仙骨神経 / 脳腸挿管 / 直腸肛門内圧検査 / 脳腸相関 / 大腸運動 / 直腸肛門奇形 / Brain-Gut axis
Research Abstract

The intestinal activity is well known to be secondarily controlled by the central nervous, system through the sympathetic and parasympathetic systems. In the pelvic region, the sacral nervous system influences the bladder and rectoanal function. However, the sacro-anorectal neural interactions in these diseases remain unclear due to the absence of a proper examination modality. We therefore examined the usefulness of sacral magnetic stimulation as a new modality for examining sacro-anorectal interaction.
Patients and Methods : Control data was obtained from 25 children without bowel dysmotility. 45 patients with chronic constipation (age range ; 1 m/o to 11 y/o), 8 pre-operative patients with Hirschsprung's disease (1 m/o to 6 y/o) and one female patient with MMIHS (1 y/o) were examined. Magnetic stimulation with a duration of one second delivered at 10 to 15Hz was applied at the S3 level using MagPro(Medtronic) with a figure eight coil while simultaneously performing the manometric rec … More ordings of the anorectal activity.
Results : In the 45 patients with chronic constipation and one patient with MMIHS, the rectoanal reflex was demonstrated by balloon rectal dilatation in all patients. Control patients uniformly exhibited a biphasic response consisting of the initial contraction followed by a relaxation. On the other hand, the sphincter response to magnetic stimulation varied among the patients with chronic constipation including no response in 5 patients, a biphasic response of an initial rise followed by a decrease in the sphincter pressure in 36 patients and only a transient rise in pressure in two patient. The MMIHS patient exhibited a transient rise in the sphincter to magnetic stimulation. In eight pre-operative patients with Hirschsprung's disease, no rectoanal reflex was observed, however, the sphincter pressure increased due to magnetic stimulation in five patients, while three patients exhibited no recordable responses.
Conclusion : These results suggest that the repetitive magnetic stimulation technique is a valuable modality for elucidating the neural interaction between the sacral nervous system and the anorectum, thereby suggesting its usefulness for obtaining a better understanding of the anorectal pathology. Less

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (35 results)

All 2006 2005 2004 Other

All Journal Article (19 results) Book (3 results) Publications (13 results)

  • [Journal Article] An 11-year-old male patient demonstrating cholangiocarcinoma associated with congenital biliary dilatation.2006

    • Author(s)
      Shinji Tanaka
    • Journal Title

      J Pediatr Surg 41

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] An 11-year-old male patient demonstrating cholongio-carcinoma associated with congenital biliary dilatation.2006

    • Author(s)
      Shinji Tanaka, et al.
    • Journal Title

      J Pediatr Surg 41

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 機能性疾患の外科最前線 ヒルシュスプルング2005

    • Author(s)
      窪田 正幸
    • Journal Title

      臨床外科 60

      Pages: 1535-1540

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 直腸肛門反射の生理学2005

    • Author(s)
      窪田 正幸
    • Journal Title

      小児外科 37

      Pages: 551-554

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Posterior sagittal anorectoplasty for a recto-vaginal fistula occurring 30 years after Swenson's operation for Hirschsprung's disease.2005

    • Author(s)
      Naoki Okuyama
    • Journal Title

      Acta Med Biol 53

      Pages: 29-32

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fecoflowmetric profiles in postoperative patients with Hirschsprung's disease.2005

    • Author(s)
      Minoru Yagi
    • Journal Title

      J Pediatr Surg 40

      Pages: 551-554

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Surgical frontier of the functional disease Hirschsprung's disease.2005

    • Author(s)
      Masayuki Kubota
    • Journal Title

      Clinical Surgery 60

      Pages: 1535-1540

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Physiology of the anorectal reflex.2005

    • Author(s)
      Masayuki Kubota
    • Journal Title

      Pediatric Surgery 37

      Pages: 551-554

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Posterior saggital anorectoplasty for a recto-vaginal fistula occurring 30 years after Swenson's operation for Hirschsprung's disease.2005

    • Author(s)
      Naoki Okuyama
    • Journal Title

      Acta Med Biol 53

      Pages: 29-32

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 機能性疾患の外科最前線 ヒルシュスプルング病2005

    • Author(s)
      窪田 正幸
    • Journal Title

      臨床外科 60

      Pages: 1535-1540

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Fecoflowmetric profiles in postoperative patients with Hirschsprung's disease.2005

    • Author(s)
      Yagi M
    • Journal Title

      J Pediatr Surg 40

      Pages: 551-554

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Posterior sagittal anorectoplasty for a recto-vaginal fistula occurring 30 years after Swenson's operation for Hirschsprung's disease2005

    • Author(s)
      Okuyama N
    • Journal Title

      Acta Med Biol 53

      Pages: 29-32

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 小児におけるラベプラゾールナトリウムの使用経験:24時間pHモニタリングを用いた効果判定2005

    • Author(s)
      奥山 直樹
    • Journal Title

      日小外会誌 41

      Pages: 9-17

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Sacral neural modulation and repetitive magnetic stimulation : Application in Pediatric Surgery2004

    • Author(s)
      Masayuki Kubota
    • Journal Title

      Acta Medica et Biologica 52

      Pages: 43-50

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Long-term follow-up status of patients with neuroblastoma after undergoing either aggressive surgery or chemotherapy2004

    • Author(s)
      Masayuki Kubota
    • Journal Title

      J Pediatr Surg 39

      Pages: 1328-1332

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effect of postoperative chemotherapy on the serum alpha-fetoprotein level in hepatoblastoma.2004

    • Author(s)
      Masayuki Kubota
    • Journal Title

      J Pediatr Surg 39

      Pages: 1775-1778

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The herbal medicine Rikkunshi-to stimulates and coordinates the gastric myoelectrical activity in post-operative dyspepsic children after gastrointestinal surgery.2004

    • Author(s)
      Minoru Yagi
    • Journal Title

      Pediatr Surg Int 19

      Pages: 760-765

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A disturbance of the gastric electric activity in post-operative patients with biliary atresia2004

    • Author(s)
      Masahiro Ohtaki
    • Journal Title

      Pediatr Surg Int 20

      Pages: 77-82

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 小児GERの新知見2004

    • Author(s)
      窪田 正幸
    • Journal Title

      Clinician 535

      Pages: 1204-1214

    • Related Report
      2004 Annual Research Report
  • [Book] 講義録 消化器学2005

    • Author(s)
      窪田 正幸
    • Total Pages
      7
    • Publisher
      メディカルビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Lecture note of Gastrointestinal disease.2005

    • Author(s)
      Masayuki Kubota
    • Total Pages
      7
    • Publisher
      Medical View Co.
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 講義録消化器学2005

    • Author(s)
      窪田 正幸
    • Total Pages
      5
    • Publisher
      メジカルビュー社
    • Related Report
      2005 Annual Research Report
  • [Publications] Masayuki Kubota: "Review : Sacral neuromodulation and repetitive magnetic stimulation -application in pediatric surgery-"Acta Med Biol. (accepted). (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Masayuki Kubota: "Long-term follow-up status of patients with neuroblastoma after undergoing either aggressive surgery or chemotherapy -a single institutional study-"J Pediatr Surg. (accepted). (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iinuma Y: "Effects of the Herbal Medicine Inchinko-to on Liver Function in Postoperative Patients With Biliary Atresia-A Pilot Study"J Pediatr Surg. 38. 1607-1611 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 窪田 正幸: "開腹手術-腸間膜損傷、腸管穿孔"小児外科. 35. 427-432 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 八木 實: "経腸栄養"臨床と研究. 80. 1040-1044 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 窪田 正幸: "新生児の嘔吐、腹満、胎便排泄遅延"小児科診療. 66. 1514-1520 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 窪田 正幸: "ブックレット新潟大学 新潟に多い病気"新潟大学 山本 正治ほか. 8 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Masayuki Kubota: "Electrophysiological properties of the aganglionic segment in Hirschsprung's disease"Surgery. 37(4). S288-S293 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masayuki Kubota: "Assessment of the sphincter muscle function before and after posterior sagittal anorectoplasty using a magnetic spinal stimulation technique"Journal of Pediatric Surgery. 37(4). 617-622 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 窪田 正幸: "成人に達した鎖肛症例の問題点"小児外科. 34(8). 921-926 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 窪田 正幸: "新しい小児の消化管機能検査法を目指して-肛門管誘発電位から脊髄磁気刺激まで-"新潟医学会雑誌. 116(10). 467-471 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 窪田 正幸: "Hirschsprung病の無神経節範囲に基づいた治療戦略"小児外科. 34(10). 1146-1151 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 窪田 正幸: "消化器疾患最新の治療2003-2004"戸田剛太郎, 杉町 圭蔵, 中村孝司. 464 (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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