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The induction of periodontal tissues by dentin-derived matrix

Research Project

Project/Area Number 14370577
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TAKANO Yoshiro  Tokyo Medical and Dental University, Biostructural Science, Professor, 大学院・医歯学総合研究科, 教授 (90126425)

Co-Investigator(Kenkyū-buntansha) TERASHIMA Tatsuo  Tokyo Medical and Dental University, Biostructural Science, Associate Professor, 大学院・医歯学総合研究科, 助教授 (20114770)
BABA Otto  Tokyo Medical and Dental University, Biostructural Science, Research Associate, 大学院・医歯学総合研究科, 助手 (90251545)
NAKANO Yukiko  Tokyo Medical and Dental University, Biostructural Science, Research Associate, 大学院・医歯学総合研究科, 助手 (20345309)
坂本 裕次郎  東京医科歯科大学, 大学院・医歯学総合研究科, 助手 (90242205)
高橋 信之  生化学工業(株), 東京研究所, 研究員
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥11,800,000 (Direct Cost: ¥11,800,000)
Fiscal Year 2004: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2003: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2002: ¥6,000,000 (Direct Cost: ¥6,000,000)
Keywordsdentin / cementum / regeneration / periodontal ligament / non-collagenous dentin matrix / bisphosphonates / HEBP / tooth / DSP / bisphosphonate
Research Abstract

The demineralized dentin matrix has been known to have a high potential to induce ectopic bone formation at the site of implantation, implicating presence of certain bioactive molecules in the dentin matrix that facilitate differentiation of local cells into the chondrogenic and/or osteogenic cells. The aim of current investigation was to test a hypothesis that matrix components of the forming root dentin may in fact contribute to the induction of periodontal tissues, primarily on the differentiation of periodontal mesenchymal cells to cementoblasts, in the process of tooth development. The final goal of the study was to identify the bioactive molecule(s) and apply the data for the regeneration of periodontal tissues.
HEBP is a type of bisphosphonate known to have high inhibitory effects on biological mineralization without causing notable interferences on the matrix forming functions of the cells of bones and teeth. We have noticed that, in the HEBP-affected animals, thick cellular cem … More entum is deposited on the root surface, where only acellular cernentum is known to form under physiological conditions, if mineralization of the forming root dentin is inhibited and hence the non-mineralized dentin surface is exposed to the future periodontal ligament. Immunohistochemical date revealed that dentin sialaprotein, one of major non-collagenous components of dentin matrix, penetrates through the non-mineralized layers of dentin and diffuses into the future periodontal ligament, implicating dynamic translocation of the proteinaceous molecules through dentin layers, if mineralization of dentin is inhibited. In such areas, amelogenin proteins could not be localized by immunohistochemistry, despite the fact that dentin matrix contains low molecular amelogenins and that odontoblasts are reported to transiently express amelogenin messages at least by PCR analyses.
In normal tooth development, the epithelial-mesenchymal interface between the enamel and dentin forming cell layers is the site of crosstalk, where various signaling molecules are crisscrossing. Our data indicate that non-mineralized mantle dentin layers allow almost free passage of various molecules between the two cell layers that respectively generate non-collagenous dentin matrix proteins and certain amelogenin mRNA splice products, which might contribute to the induction of cementoblasts and further the formation of periodontal tissues. Introduction of highly sensitive analytical methods in future studies may allow visualization of distinct localization of candidate molecules for the induction of cementoblasts at the site of de novo formation of root dentin surface. Less

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (59 results)

All 2004 2003 2002 Other

All Journal Article (45 results) Book (2 results) Publications (12 results)

  • [Journal Article] 歯の石灰化2004

    • Author(s)
      高野吉郎
    • Journal Title

      Clinical Calcium 14.6

      Pages: 29-33

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] The induction of enamel and dentin complexes by subcutaneous implantation of reconstructed human and murine tooth germ elements2004

    • Author(s)
      N.Isogawa
    • Journal Title

      Arch Histol Cytol 67・1

      Pages: 65-77

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Histochemical localization of cholinesterase activity in the dental epithelium of guinea pig teeth.2004

    • Author(s)
      C.K.Jayawardena
    • Journal Title

      Anat Embryol 208・4

      Pages: 281-287

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Site-specific localization of two distinct phosphatases along the osteoblast plasma membrane : tissue non-specific alkaline phosphatase and plasma membrane calcium ATPase2004

    • Author(s)
      Y.Nakano
    • Journal Title

      Bone 36・5

      Pages: 1077-1085

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Eccentric Localization of Osteocytes Expressing Enzymatic Activities, Protein, and mRNA Signals for Type 5 Tartrate-resistant Acid Phosphatase (TRAP).nd mRNA Signals for Type 5 Tartrate-resistant Acid Phosphatase (TRAP).2004

    • Author(s)
      Y.Nakano
    • Journal Title

      J Histochem Cytochem 52・11

      Pages: 1475-1482

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Appearance of electron-dense segments : Indication of possible conformational changes of pre-mineralizing collagen fibrils in the osteoid of rat bones2004

    • Author(s)
      Y.Asawa
    • Journal Title

      J Electron Microsc 53・4

      Pages: 423-433

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Histochemical localization of cholinesterase activity in the dental epithelium of guinea pig teeth.2004

    • Author(s)
      Jayawardena CK, Takano Y
    • Journal Title

      Anat Embryol 208

      Pages: 281-287

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Eccentric Localization of Osteocytes Expressing Enzymatic Activities, Protein, and mRNA Signals for Type5 Tartrate-resistant Acid Phosphatase (TRAP).2004

    • Author(s)
      Nakano Y, Toyosawa H, Takano Y
    • Journal Title

      J Histochem Cytochem. 52(11)

      Pages: 1475-1482

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Site-specific localization of two distinct phosphatases along the osteoblast plasma membrane : tissue non-specific alkaline phosphatase and plasma membrane calcium ATPase.2004

    • Author(s)
      Nakano Y, Beertsen W, VanDenBos T, Kawamoto T, Oda K, Takano Y.
    • Journal Title

      Bone 35(5)

      Pages: 1077-1085

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Accelerated bone formation and increased osteoblast number contribute to the abnormal tooth germ development in parathyroid hormone-related protein (PTHrP)-knockout mice.2004

    • Author(s)
      Kitahara Y, Suda N, Terashima T, Baba O, Mekaapiruk K, Hammond VE, Takano Y, Ohyama K
    • Journal Title

      Bone 35(5)

      Pages: 1100-1106

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Appearance of electron-dense segments : Indication of possible conformational changes of pre-mineralizing collagen fibrils in the osteoid of rat bones.2004

    • Author(s)
      Asawa Y, Aoki K, Ohya K, Ohshima H, Takano Y
    • Journal Title

      J Electron Microsc 53(4)

      Pages: 423-433

    • NAID

      10014037216

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The induction of enamel and dentin complexes by subcutaneous implantation of reconstructed human and murine tooth germ elements.2004

    • Author(s)
      Isogawa N, Terashima T, Nakano Y, Kindaichi J, Takagi Y, Takano Y.
    • Journal Title

      Arch Histol Cytol. 67(1)

      Pages: 65-77

    • NAID

      10012846467

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Age-related Changes and Possible Adaptability of Rat Jaw Muscle Spindles : Immunohistochemical and Fine Structural Studies.2004

    • Author(s)
      Winarakwong L., Muramoto T., Soma K, Takano Y.
    • Journal Title

      Arch Histol Cytol 67(3)

      Pages: 227-240

    • NAID

      10014045112

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The induction of enamel and dentin complexes by subcutaneous implantation of reconstructed human and murine tooth germ elements2004

    • Author(s)
      Isogawa N, Terashima T, Nakano Y, Kindaichi J, Takano Y
    • Journal Title

      Arch Histol Cytol 67・1

      Pages: 65-77

    • NAID

      10012846467

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Histochemical localization of cholinesterase activity in the dental epithelium of guinea pig teeth2004

    • Author(s)
      Jayawardena CK, Takano Y
    • Journal Title

      Anat Embryol 208・4

      Pages: 281-287

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Site-specific localization of two distinct phosphatases along the osteoblast plasma membrane : tissue non-specific alkaline phosphatase and plasma membrane calcium ATPase2004

    • Author(s)
      Nakano Y, Beertsen W, VanDenBos T, Kawamoto T, Oda K, Takano Y.
    • Journal Title

      Bone 36・5

      Pages: 1077-1085

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Eccentric Localization of Osteocytes Expressing Enzymatic Activities, Protein, and mRNA Signals for Type 5 Tartrate-resistant Acid Phosphatase (TRAP).2004

    • Author(s)
      Nakano Y, Toyosawa H, Takano Y
    • Journal Title

      J Histochem Cytochem 52・11

      Pages: 1475-1482

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Appearance of electron-dense segments : Indication of possible conformational changes of pre-mineralizing collagen fibrils in the osteoid of rat bones2004

    • Author(s)
      Asawa Y, Aoki K, Ohya K, Ohshima H, Takano Y
    • Journal Title

      J Electron Microsc 53・4

      Pages: 423-433

    • NAID

      10014037216

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Possible role of dentin matrix on region-specific deposition of cellular and a cellular extrinsic fiber cementum.2003

    • Author(s)
      Y.Takano
    • Journal Title

      J Electron Microsc 52(6)

      Pages: 573-580

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Stage-specific Contribution of Cholinesterase in Amelogenesis of Guinea Pig Teeth2003

    • Author(s)
      Y.Takano
    • Journal Title

      Archives of Comparative Biology of Tooth Enamel 8

      Pages: 16-20

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of enamel formation in mutant rats with hypoplastic type of amelogenesis imperfecta.2003

    • Author(s)
      T.Terashima
    • Journal Title

      Dentistry in Japan 39

      Pages: 8-14

    • NAID

      10016196624

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene expression of GDFs in the developing periodontium of rat molars2003

    • Author(s)
      Y.Takano
    • Journal Title

      J.Dent.Res 82(3)

      Pages: 166-171

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Alkaline and acid phosphatase in bone cells serve as phosphohydrolases at physiological pH in vivo : A histochemical implication.2003

    • Author(s)
      Y.Nakano
    • Journal Title

      Connective Tissue Res 44(suppl 1)

      Pages: 219-222

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 歯の石灰化2003

    • Author(s)
      高野 吉郎
    • Journal Title

      Clinical Calcium 33(9)

      Pages: 81-85

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of enamel formation in mutant rats with hypoplastic type of amelogenesis imperfecta.2003

    • Author(s)
      Terashma T, Baba O, Takano Y, Ishibashi K, Oida S
    • Journal Title

      Dentistry in Japan 39

      Pages: 8-14

    • NAID

      10016196624

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene expression of GDFs in the developing periodontium of rat molars.2003

    • Author(s)
      Sena K, Morotome Y, Baba O, Terashima T, Takano Y, Ishikawa I
    • Journal Title

      J.Dent.Res. 82(3)

      Pages: 166-171

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Development of a liquid culture system for megakaryocyte terminal differentiation : Fibrinogen promotes megakaryocytopoiesis but not thrombopoiesis.2003

    • Author(s)
      Sato, T, Ono M, Fujita H, Tanaka H, Tomiyama J, Sakamoto Y, Takano Y, Murota S, Morita I
    • Journal Title

      Br.J.Haematol. 121

      Pages: 315-323

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The Pulpal Regeneration after Cavity Preparation, with Special Reference to Close Spatio-relationships between Odontoblasts and Immunocompetent Cells.2003

    • Author(s)
      Ohshima H, Nakakura-Ohshima K, Takeuchi K, Hoshino M, Takano Y, Maeda T
    • Journal Title

      Microsc.Res.Tech. 60

      Pages: 483-490

    • NAID

      120006735767

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Possible role of dentin matrix on region-specific deposition of cellular and acellular extrinsic fiber cementum.2003

    • Author(s)
      Takano Y, Sakai H, Watanabe E, Ideguchi-Ohma N, Jayawardena CK, Arai K, Asawa K, Nakano Y, Shuda Y, Sakamoto Y, Terashima T
    • Journal Title

      J Electron Microsc. 52 (No.6)

      Pages: 573-580

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Alkaline and acid phosphatases in bone cells serve as phosphohydrolases at physiological pH in vivo : a histochemical implication.2003

    • Author(s)
      Nakano Y, Kawamoto T, Takano Y.
    • Journal Title

      Connect Tissue Res. 44 Suppl 1

      Pages: 219-222

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] GAP-43 immunohistochemical and ultrastructural changes in jaw muscle spindles of the rat following loss of occlusion.2002

    • Author(s)
      P.Santiwong
    • Journal Title

      Archs Oral Biol. 47

      Pages: 227-237

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Disturbed Tooth Development in Parathyroid Hormone-related Protein (PTHrP) Gene-knockout Mice2002

    • Author(s)
      Y.Kitahara
    • Journal Title

      Bone 30

      Pages: 48-56

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of Alternatively Spliced RNA Transcripts of Amelogenin Gene Exons 8 and 9 and its End Products in the Rat Incisor.2002

    • Author(s)
      O.Baba
    • Journal Title

      J.Histochem.Cytochem. 50

      Pages: 1229-1236

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of a potential mineralization inhibitor on formation of cementum pearls, a type of acellular extrinsic fiber cementum in guinea pig molars, with special references to the origin of intrinsic matrix and process of mineralization.2002

    • Author(s)
      C.Jayawardena
    • Journal Title

      Eur.J Oral Sci. 110

      Pages: 261-269

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parathyroid hormone-related protein (PTHrP) uis not required for mouse tooth germ development but indispensable for maintenance of osteoclastgenesis in the alveolar bone.2002

    • Author(s)
      K.Mekaariruk
    • Journal Title

      Arch Oral Biol. 47(9)

      Pages: 665-672

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ca-binding Domains in the Odontoblast Layer of Rat Molars and Incisors Under Normal and Pathological Conditions.2002

    • Author(s)
      E.Watanabe
    • Journal Title

      Arch.Histol.Cytol. 65(3)

      Pages: 233-244

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Disturbed tooth development in parathyroid hormone-related protein (PTHrP)-gene knockout mice.2002

    • Author(s)
      Kitahara Y, Suda N, Kuroda T, Beck F, Hammond VE, Takano Y
    • Journal Title

      Bone 30(1)

      Pages: 48-56

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Growth-associated protein-43 immunohistochemical and ultrastructural changes in jaw muscle spindles of the rat following loss of occlusion.2002

    • Author(s)
      Santiwong P, Muramoto T, Soma K, Takano Y
    • Journal Title

      Arch Oral Biol. 47

      Pages: 227-237

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] An attempt of pH mapping on biological speciments by pH-imaging microscope using a semiconductor silicon sensor2002

    • Author(s)
      Nakano Y, Nomura S, Kawamoto T, Tagami J, Horiba A, Takano Y
    • Journal Title

      BUNSEKI KAGAKU 51(6)

      Pages: 473-476

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] On the origin of intrinsic matrix of acellular extrinsic fiber cementum : studies on growing cementum pearls of normal and bisphosphonate-affected guinea pig molars.2002

    • Author(s)
      Jayawardena CK, Takahashi N, Watanabae E, Takano Y
    • Journal Title

      Eur J Oral Sci 110(3)

      Pages: 261-269

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A unique localization of mechanoreceptors in the periodontal tissue of guinea pig teeth.2002

    • Author(s)
      Jayawardena CK, Takahashi N, Takano Y
    • Journal Title

      Arch Histol Cytol 65(3)

      Pages: 233-244

    • NAID

      50000651394

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The influence of parathyroid hormone-related protein (PTHrP) on tooth-germ development and osteoclastogenesis in alveolar bone of PTHrP-knock out and wild-type mice in vitro.2002

    • Author(s)
      Mekaapiruk K, Suda N, Hammond VE, Beck F, Kuroda T, Takano Y, Terashima T
    • Journal Title

      Arch Oral Biol. 47(9)

      Pages: 665-672

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of Alternatively Spliced RNA Transcripts of Amelogenin Gene Exons 8 and 9 and its End Products in the Rat Incisor.2002

    • Author(s)
      Baba O, Takahashi N, Terashima T, Li W, DenBesten PK, Takano Y
    • Journal Title

      J.Histochem.Cytochem.

      Pages: 1229-1236

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Morphological influence of ascorbic acid deficiency on endochondral ossification in osteogenic disorder Shionogi rat.2002

    • Author(s)
      Sakamoto Y, Takano Y
    • Journal Title

      Anat Rec 268(2)

      Pages: 93-104

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ca-binding Domains in the Odontoblast Layer of Rat Molars and Incisors under Normal and Pathological Conditions.2002

    • Author(s)
      Watanabe E, Takano Y
    • Journal Title

      Arch Histol Cytol 65(4)

      Pages: 337-346

    • NAID

      10012312891

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 新・う蝕の科学

    • Author(s)
      高野吉郎
    • Publisher
      医歯薬出版(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 新・う蝕の科学

    • Author(s)
      高野吉郎
    • Publisher
      医歯薬出版(印刷中)
    • Related Report
      2004 Annual Research Report
  • [Publications] Y.TAKANO: "Possible role of dentin matrix on region-specific deposition of cellular and acellular extrinsic fiber cementum."J Electron Microsc. 52(6). 573-580 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.TAKANO: "Stage-specific Contribution of Cholinesterase in Amelogenesis of Guinea Pig Teeth."Archives of Comparative Biology of Tooth Enamel. 8. 16-20 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.TERASHIMA: "Analysis of enamel formation in mutant rats with hypoplastic type of amelogenesis imperfacta."Dentistry in Japan. 39. 8-14 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.TAKANO: "Gene expression of GDFs in the developing periodontium of rat molars."J.Dent.Res. 82(3). 166-171 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.NAKANO: "Alkaline and acid phosphatase in bone cells serve as phosphohydrolases at physiological pH in vivo : A histochemical implication."Connective Tissue Res. 44(Suppl 1). 219-222 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 高野 吉郎: "歯の石灰化"Clinical Calcium. 33(9). 81-85 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] P.Santiwong: "GAP-43 immunohistochemical and ultrastructural changes in jaw muscle spindles of the rat following loss of occlusion"Archs Oral Biol.. 47. 227-237 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Kitahara: "Disturbed Tooth Development in Parathyroid Hormone-related Protein (PTHrP) Gene-knockout Mice"Bone. 30. 48-56 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] O.Baba: "Expression of Alternatively Spliced RNA Transcripts of Amelogenin Gene Exons 8 and 9 and its End Products in the Rat Incisor"J. Histochem. Cytochem.. 50. 1229-1236 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] C.Jayawardena: "Effects of a potential mineralization inhibitor on formation of cementum pearls, a type of acellular extrinsic fiber cementum in guinea pig molars, with special references to the origin of intrinsic matrix and process of mineralization"Eur. J Oral Sci.. 110. 261-269 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Mekaariruk: "Parathyroid hormone-related protein (PTHrP) uis not required for mouse tooth germ development but indispensable for maintenance of ossteoclastgenesis in the alveolar bone"Arch Oral Biol.. 47(9). 665-672 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] E.Watanabe: "Ca-binding Domains in the Odontoblast Layer of Rat Molars and Incisors Under Normal and Pathological Conditions"Arch. Histol. Cytol.. 65(3). 233-244 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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