| Project/Area Number |
14370593
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YAMAMOTO Takashi Osaka University, Graduate School of Human Sciences, Professor, 人間科学研究科, 教授 (60028793)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMURA Tsuyoshi Osaka University, Graduate School of Human Sciences, 人間科学研究科, 助教授 (80150332)
INUI Tadashi Osaka University, Graduate School of Human Sciences, Res.Associate, 人間科学研究科, 助手 (40324735)
MURAKAMI Hideaki Osaka University, Graduate School of Dentistry, Assistant Professor, 歯学研究科, 助教授 (00263301)
INOUE Tomio Shouwa University, School of Dentistry, Professor, 歯学部, 教授 (70184760)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥13,500,000 (Direct Cost: ¥13,500,000)
Fiscal Year 2004: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2003: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 2002: ¥5,500,000 (Direct Cost: ¥5,500,000)
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| Keywords | taste / brain / preference / aversion / learning / imaging |
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| Research Abstract |
The purpose of the present research project was to reveal brain substances activated by taste stimuli and to show plastic changes of responsiveness of neurons by those substances in rats. The experiments on humans aims to disclose brain functions about taste quality processing and hedonic evaluation of taste with the use of non-invasive brain imaging techniques. The following results were obtained :
1)Brain mechanisms of taste preference learning : Injections of a dopamine D1 receptor antagonist or a glutamine receptor antagonist into the ventral pallidum decreased saccharin intake, while a opioid receptor antagonist increased saccharin intake.
2)Microdialysis study : Brain histamine release was increased by quinine, but no release by sucrose or saccharin, indicating that histamine release was related aversive taste.
3)Brain mechanisms of taste aversion learning : Injections of bicuculline, GABA receptor antagonist, into the ventral pallidum in the rat trained to reject saccharin attenuated aversions to saccharin.
4)Non-invasive brain imaging study : Magnetic response of the brain was greater to simultaneous simulation of odor and visual image when delivered matched than mismatched.
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