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Effect of particle size on biocompatibility and biochemical evaluation of properties for various materials

Research Project

Project/Area Number 14370623
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

WATARI Fumio  Hokkaido University, Graduate School of Dental Medicine, Professor, 大学院・歯学研究科, 教授 (70158682)

Co-Investigator(Kenkyū-buntansha) TAKASHI Noriyuki  Hokkaido University, Medical&Dental Hospital, Research Associate, 医学部・歯学部附属病院, 助手 (40312376)
TOTSUKA Yasunori  Hokkaido University, Graduate School of Dental Medicine, Professor, 大学院・歯学研究科, 教授 (00109456)
UO Motohiro  Hokkaido University, Graduate School of Dental Medicine, Associate Professor, 大学院・歯学研究科, 助教授 (20242042)
AKASAKA Tsukasa  Hokkaido University, Graduate School of Dental Medicine, Research Associate, 大学院・歯学研究科, 助手 (00360917)
YOKOYAMA Atsuro  Hokkaido University, Medical&Dental Hospital, Lecturer, 医学部・歯学部附属病院, 講師 (20210627)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 2003: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2002: ¥9,200,000 (Direct Cost: ¥9,200,000)
KeywordsBiomaterial / Biocompatibility / Cell functional test / Nanomaterial / Nanutoxicoloy / Cytokine / Fine particles / Implant / 好中球 / マクロファージ / 活性酸素
Research Abstract

[Purpose]In dental material the powder/liquid method is abundantly used and abrasion powder arises in the sliding part of artificial joint. To study the effect of powders on health the size dependence of fine particles on biocompatibility was investigated by cell functional test and implantation test.
[Method] Monodispersed particles were extracted by sedimentation for the size 0.5, 3, 10μm and by ultrafiltration for less than 300nm. The particles were thus prepared with the same size for different materials.
[Size dependence] In cell functional test using the human neutrophil, periodontal ligament cell and rat macrophage, the cell survival rate was lowered and the emission of LDH, oxygen radical, cytokines TNF-α, IL-1β, IL-8, M-CSF increased as particle size became smaller, for Ti, Fe, Ni(each 500nm ; 3,10, 50, 150μm), TiO_2(30, 60, 300, 500nm ; 2μm), polylactic acid (1, 13μm). Especially, for the case of smaller than 10μm where phagocytosis was induced, the effect was remarkably pronou … More nced. The stimulatibility of these effects is lower by about 1/100〜1/1000 than the intracellular toxicity.
[Material dependence]Both Ti whose ionic dissolution was negligible, confirmed by the ICP elemental analysis, and Fe, much more dissolvable, showed the similar size dependency. In Ni, cell survival rate was lower, emission of oxygen radical and cytokine was larger, the cell destruction was observed by microscopy, which was due to the stronger cytotoxicity of Ni.
[Conclusion]In animal implantation test, Ti particles showed biocompatibility for the size larger than about 100μm, and inflammation for smaller than 50μm. For less than 10μm phagocytosis was induced and inflammation was continued for the long term. For the biocompatibility in the material with a macroscopic size the material-dependent, chemical effect through dissolved ions is generally dominant. For the range of μm〜nm, the material-independent, physical size effect origined from the relative size relation between particles and cell/tissue becomes tangible, even for the bioactive and bioinert materials. Less

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (82 results)

All Other

All Publications (82 results)

  • [Publications] Fumio Watari: "Mechanical Properties and Biocompatibility of Surface-Nitrided Titanium for Abrasion Resistant Implant"Bioceramics (Key Engineering Materials Vols.254-256). 16. 873-876 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Tamura: "Effects of Micro/Nano Particle Size on Cell Function and Morphology"Bioceramics (Key Engineering Materials Vols.254-256). 16. 919-922 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fumio WATARI4: "Biocompatibility of materials and development to functionally graded implant for bio-medical application"Composites Science and Technology. 64・6. 893-908 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 亘理文夫: "微粒子と生体反応"ナノ学会会報. 2・1. 33-37 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 亘理文夫: "傾斜機能型デンタルポストの応用緩和効果"2002年度傾斜機能材料論文集<FGM2002>. 93-97 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fumio WATARI: "Development of functionally graded implant and dental post for bio-medical application"Functionally Graded Materials 2002. 423-425. 321-326 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 亘理文夫: "傾斜機能型人工歯根の開発と課題"傾斜機能材料の開発と応用(シーエムシー出版). 149-158 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 横山敦郎: "生体材料(デンタルインプラント)を目的とした傾斜機能材料の作製と生体反応"化学工業. 54・11. 13-18 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Junko KONISHI: "Effect of Sphered Particles on the Firing Contraction of Pocelain Inlay Processed by Cold Isostatic Pressing"J.Biomed.Mater.Res.. 66B. 553-558 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Magda Kiyoko Yamada: "Imaging and Non-Contact Profile Analysis of Nd:YAG Laser-Irradiated Teeth by Scanning Electron Microscopy and Confocal Laser Scanning Microscopy"Dental Materials Journal. 22. 556-568 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Magda Kiyoko Yamada: "CLSM and SEM quantitative analysis of surface topography of human teeth irradiated by Nd:YAG, Er:YAG and CO_2 lasers"Proc.8th Int.Congr.Laser in Dentistry International Congress Series. 1248. 135-137 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kazutoshi TANI: "Discrimination between Composite Resin and Teeth using Fluorescence Properties"Dental Materials Journal. 22. 569-580 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Atsuro Yokoyama: "Tissue response to a newly developed calcium phosphate cement containing succinic acid and carboxymethyl-chitin"J.Biomed.Mater.Res.. 64A. 491-501 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Motohiro Uo: "Cytotoxicity and bonding property of dental ceramics"Dental Materials. 19. 487-492 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Motohiro Uo: "Surface analysis of dental amalgams by X-ray photoelectron spectroscopy and X-ray diffraction"Dental Materials. 19. 639-644 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Min Ho Lee: "Biocompatibility of Surface Treated Pure Titanium and Titanium Alloy by in vivo and in vitro Test"Metals and Materials International. 9・1. 35-42 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Suwa: "Static-Dynamic Friction Transition of FRP Esthetic orthodontic wires on various brackets by suspension type friction test"J.Biomedical Materials Research. 66B. 765-771 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 田村一央: "ナノ・マイクロ微粒子が及ぼす生体為害性の評価"第15回代用臓器研究会プログラム・抄録集. 3 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 豊泉 裕: "光重合法によるアーチ型審美矯正ワイヤーの開発"歯科材料・器械. 21・5. 271-277 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 山方秀一: "審美性に優れた歯科矯正ワイヤーの開発"材料と環境. 51・12. 555-560 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ryuichi KUMAZAWA: "Effects of Ti ions and particles on cellular function and morphology of neutrophils"Biomaterials. 23. 3757-3764 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kazuchika TAMURA: "Effects of particle size on cell function and morphology in titanium and nickel"Materials Transactions. 43・12. 3052-3057 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yutaka Tamura: "Mechanical properties of surface-nitrided titanium for abrasion resistant implant materials"Materials Transactions. 43・12. 3043-3051 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yutaka TAMURA: "Surface Properties and Biocompatibility of Nitrided Titanium for Abrasion Resistant Implant Materials, DENTAL MATERIALS JOURNAL Vol.21 No.4,355-372"DENTAL MATERIALS JOURNAL. 21・4. 355-372 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 谷村幸広: "金属イオン修飾による二酸化チタン光触媒の可視光応答性付与と歯科応用のための基礎研究"歯科材料・器械. 21・6. 342-350 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 亘理文夫: "FGMインプラントの特性に及ぼすSPS焼結圧の効果と生体適合性"粉体および粉末冶金、粉体粉末冶金協会. 49・12. 1063-1069 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 小西順子: "冷間等加圧法を用いた陶材インレーの焼成後収縮に及ぼす中間酸化物添加の影響"歯科材料・器械. 21・6. 357-367 (2002)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 小西順子: "冷間等加圧法で作製した陶剤インレーに及ぼす脱バインダー化球状粉末の影響"日本歯科保存学雑誌. 45・6. 1213-1222 (2002)

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      「研究成果報告書概要(和文)」より
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      2003 Final Research Report Summary
  • [Publications] 谷村幸広: "イオン修飾二酸化チタンの可視光応答性光蝕能と抗菌性"2002年3学協会北海道支部研究発表会講演要旨集. A16. 19 (2002)

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      「研究成果報告書概要(和文)」より
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      2003 Final Research Report Summary
  • [Publications] 谷村幸広: "イオン修飾二酸化チタンの可視応答性光触媒能の検証"歯科材料・器械. 21・S39. 107 (2002)

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      「研究成果報告書概要(和文)」より
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      2003 Final Research Report Summary
  • [Publications] 亘理文夫: "先進歯科材料研究に関する最近の動向"材料の微細組織と機能性第133委員会174回研究会資料. 13 (2002)

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      「研究成果報告書概要(和文)」より
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      2003 Final Research Report Summary
  • [Publications] 近藤英臣: "窒化チタン/アパタイト系傾斜機能型インプラントの作製と評価"歯科材料・器械. 21・S40. 33 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 田村一央: "金属微粒子の細胞機能性試験と粒径効果"歯科材料・器械. 21・S40. 94 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 田村一央: "チタン粒子が及ぼす細胞為害性のサイズ依存と粒径効果"第50回国際歯科研究学会日本部会(JADR)総会・学術大会. 32. 106 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fumio Watari, Yutaka Tamura, Atsuro Yokoyama, Motohiro Uo, Takao Kawasaki: "Mechanical Properties and Biocompatibility of Surface-Nitrided Titanium for Abrasion Resistant Implant"Bioceramics (Key Engineering Materials Vol.254-256). 16. 873-876 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Tamura, N.Takashi, T.Akasaka, I.D.Rosca, M.Un, Y.Totsuka, F.Watari: "Effects of Micro/Nano Particle Size on Cell Function and Morphology"Bioceramics (Key Engineering Materials Vol.254-256). 16. 919-922 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fumio WATARI, Atsuro YOKOYAMA, Mamoru OMORI, Toshio HIRAI, Hideomi KONDO, Motohiro UO, Takao KAWASAKI: "Biocompatibility of materials and development to functionally graded implant for bio-medical application"Composites Science and Technology. 64(6). 893-908 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fumio Watari, Kazuchika Tamura, Noriyuki Takashi, Motohiro Uo, Tsukasa Akasaka, Yasunori Totsuka, Bunshi Fugetsu, Yoshinori Sato, Kazuyuki Tohji: "Fine Particles and Bioreaction"The Bulletin of the Society of Nano Science and Technology. 2(1). 33-37 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fumio WATARI, Hideomi KONDO, Shingo MATSUO, Rika MIYAO, Atsuro YOKOYAMA, Mamoru OMORI, Toshio HIRAI, Yutaka TAMURA, Motohiro UO, Noboru OHATA, Takao KAWASAKI: "Development of functionally graded implant and dental post for bio-medical application"FGM 2002 (Ed.W.PAN, Trans Tech Publications, Zurich). vol423-425. 321-326 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Junko KONISHI, Fumio WATARI, Chiharu KAWAMOTO, Hidehiko SANO: "Effect of Sphered Particles on the Firing Contraction of Porcelain Inlay Processed by Cold Isostatic Pressing"J Biomed Master Res Part B : Appl Biomater (Wiley Periodicals, Inc.). 66B. 553-558 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Magda Kiyoko Yamada, Fumio Watari: "Imaging and Non-Contact Profile Analysis of Nd : YAC Laser-Irradiated Teeth by Scanning Electron Microscopy and Confocal Laser Scanning Microscopy"Dental Materials Journal. 22. 556-568 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kazutoshi Tani, Fumie Watari, Motohiro Uo: "Discrimination between Composite Resin and Teeth using Fluorescence Properties"Dental Materials Journal. 22. 569-580 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Suwa, F.Watari, S.Yamagata, J.Iida, M.Kobayashi: "Static-Dynamic Friction Transition of FRP Esthetic orthodontic wires on various brackets by suspension type friction test"Biomedical Materials Research. 66. 765-771 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ryuichiro KUMAZAWA, Fumio WATARI, Noriyuki TAKASHI, Yukihiro TANIMURA, Motohiro UO, Yasunori TOTSUKA: "Effects of Ti ions and particles on cellular function and morphology of neutrophils"Biomaterials. 23. 3757-3764 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kazuchika TAMURA, Noriyuki TAKASHI, Ryuichiro KUMAZAWA, Fumie WATARI, Yasunori TOTSUKA: "Effects of particle size on cell function and morphology in titanium and nickel"Materials Transactions. 43(12). 3052-3057 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yutaka Tamara, Atsuro YOKOYAMA, Fumio WATARI, Mutohiro UO, Takao KAWASAKI: "Mechanical properties of surface-nitrided titanium for abrasion resistant implant materials"Materials Transactions. 43(12). 3043-3051 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yutaka TAMURA, Atsuro Yokohama, Takao KAWASAKI: "Surface Properties and Biocompatibility of Nitrided Titanium for Abrasion Resistant Implant Materials"DENTAL MATERIALS JOURNAL. 21(4). 355-372 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yukihiro TANIMURA, Fumio WATARI, Motohiro UO, Yasunori TOTSUKA: "【table】Visible Light Responsibility of Titanium Photocatalyst by Metal Ion Decoration and Research into Its Dental Application"The Journal of the Japanese Society for Dental Materials and Devices. Vol.21, No.6. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fumio Watari: "Mechanical Properties and Biocompatibility of Surface-Nitrided Titanium for Abrasion Resistant Implant"Bioceramics (Key Engineering Materials Vols.254-256). 16. 873-876 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Tamura: "Effects of Micro/Nano Particle Size on Cell Function and Morphology"Bioceramics (Key Engineering Materials Vols.254-256). 16. 919-922 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fumio WATARI: "Biocompatibility of materials and development to functionally graded implant for bio-medical application"Composites Science and Technology. 64・6. 893-908 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 亘理文夫: "微粒子と生体反応"ナノ学会会報. 2・1. 33-37 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 亘理文夫: "傾斜機能型デンタルポストの応用緩和効果"2002年度傾斜機能材料論文集<FGM2002>. 93-97 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fumio WATARI: "Development of functionally graded implant and dental post for bio-medical application"Functionally Graded Materials 2002. 423-425. 321-326 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 亘理文夫: "傾斜機能型人工歯根の開発と課題"傾斜機能材料の開発と応用(シーエムシー出版). 149-158 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 横山敦郎: "生体材料(デンタルインプラント)を目的とした傾斜機能材料の作製と生体反応"化学工業. 54・11. 13-18 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Junko KONISHI: "Effect of Sphered Particles on the Firing Contraction of Porcelain Inlay Processed by Cold Isostatic Pressing"J.Biomed.Mater.Res.. 66B. 553-558 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Magda Kiyoko Yamada: "Imaging and Non-Contact Profile Analysis of Nd : YAG Laser-Irradiated Teeth by Scanning Electron Microscopy and Confocal Laser Scanning Microscopy"Dental Materials Journal. 22. 556-568 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Magda Kiyoko Yamada: "CLSM and SEM quantitative analysis of surface topography of human teeth irradiated by Nd : YAG, Er : YAG and CO_2 lasers"Proc.8th Int.Congr.Laser in Dentistry International Congress Series. 1248. 135-137 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kazutoshi TANI: "Discrimination between Composite Resin and Teeth using Fluorescence Properties"Dental Materials Journal. 22. 569-580 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Atsuro Yokoyama: "Tissue response to a newly developed calcium phosphate cement containing succinic acid and carboxymenthyl-chitin"J.Biomed.Mater.Res.. 64A. 491-501 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Motohiro Uo: "Cytotoxicity and bonding property of dental ceramics"Dental Materials. 19. 487-492 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Motohiro Uo: "Surface analysis of dental amalgams by X-ray photoelectron spectroscopy and X-ray diffraction"Dental Materials. 19. 639-644 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Min Ho Lee: "Biocompatibility of Surface Treated Pure Titanium and Titanium Alloy by in vivo and in vitro Test"Metals and Materials International. 9・1. 35-42 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Suwa: "Static-Dynamic Friction Transition of FRP Esthetic orthodontic wires on various brackets by suspension type friction test"J.Biomedical Materials Research. 66B. 765-771 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 豊泉 裕: "光重合法によるアーチ型審美矯正ワイヤーの開発"歯科材料・器械. 21・5. 271-277 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] 山方秀一: "審美性に優れた歯科矯正ワイヤーの開発"材料と環境. 51・12. 555-560 (2002)

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      2003 Annual Research Report
  • [Publications] Ryuichi KUMAZAWA: "Effects of Ti ions and particles on cellular function and morphology of neutrohils"Biomaterials. 23. 3757-3764 (2002)

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  • [Publications] Kazuchika TAMURA: "Effects of particle size on cell function and morphology in titanium and nickel"Materials Transactions. 43・12. 3052-3057 (2002)

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  • [Publications] Yutaka Tamura: "Mechanical properties of surface-nitrided titanium for abrasion resistant implant materials"Materials Transactions. 43・12. 3043-3051 (2002)

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  • [Publications] Yutaka TAMURA: "Surface Properties and Biocompatibility of Nitrided Titanium for Abrasion Resistant Implant Materials, DENTAL MATERIALS JOURNAL Vol.21 No.4, 355-372"DENTAL MATERIALS JOURNAL. 21・4. 355-372 (2002)

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  • [Publications] 谷村幸広: "金属イオン修飾による二酸化チタン光触媒の可視光応答性付与と歯科応用のための基礎研究"歯科材料・器械. 21・6. 342-350 (2002)

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  • [Publications] 亘理文夫: "FGMインプラントの特性に及ぼすSPS焼結圧の効果と生体適合性"粉体および粉末冶金、粉体粉末冶金協会. 49・12. 1063-1069 (2002)

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  • [Publications] 小西順子: "冷間等加圧法を用いた陶材インレーの焼成後収縮に及ぼす中間酸化物添加の影響"歯科材料・器械. 21・6. 357-367 (2002)

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  • [Publications] 小西順子: "冷間等加圧法で作製した陶剤インレーに及ぼす脱バインダー化球状粉末の影響"日本歯科保存学雑誌. 45・6. 1213-1222 (2002)

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  • [Publications] 谷村幸広: "イオン修飾二酸化チタンの可視光応答性光触能と抗菌性"2002年3学協会北海道支部研究発表会講演要旨集. A16. 19-19 (2002)

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  • [Publications] 田村一央: "ナノ・マイクロ微粒子が及ぼす生体為害性の評価"第15回代用臓器研究会プログラム・抄録集. 3-3 (2003)

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  • [Publications] 谷村幸広: "イオン修飾二酸化チタンの可視応答性光触媒能の検証"歯科材料・器械. 21・S39. 107-107 (2002)

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  • [Publications] 亘理文夫: "先進歯科材料研究に関する最近の動向"材料の微細組織と機能性第133委員会第174回研究会資料. 13-13 (2002)

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  • [Publications] 近藤英臣: "窒化チタン/アパタイト系傾斜機能型インプラントの作製と評価"歯科材料・器械. 21・S40. 33-33 (2002)

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  • [Publications] 田村一央: "金属微粒子の細胞機能性試験と粒径効果"歯科材料・器械. 21・S40. 94-94 (2002)

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  • [Publications] 田村一央: "チタン粒子が及ぼす細胞為害性のサイズ依存と粒形効果"第50回国際歯科研究学会日本部会(JADR)総会・学術大会. 32. 106-106 (2002)

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Published: 2002-04-01   Modified: 2016-04-21  

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