• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Comprehensive study of sentinel lymph node biopsy in oral cancer.

Research Project

Project/Area Number 14370659
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

OMURA Ken  Tokyo Medical and Dental University, Oral and Maxillofacial Surgery, Professor, 大学院・医歯学総合研究科, 教授 (10334434)

Co-Investigator(Kenkyū-buntansha) TOGAWA Takashi  Chiba Cancer Center, The Division of Nuclear Medicine, Division Chief, 核医学診療部, 部長 (10145625)
HARADA Hiroyuki  Tokyo Medical and Dental University, Oral and Maxillofacial Surgery, Research Assistant, 歯学部付属病院, 助手 (40343149)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥11,900,000 (Direct Cost: ¥11,900,000)
Fiscal Year 2004: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2002: ¥7,600,000 (Direct Cost: ¥7,600,000)
KeywordsOral cancer / Cervical lymph node metastasis / Elective neck dissection / SN concept / RI / Immunohistochemistry / RT-PCR / SNNS / 扁平上皮癌 / 頸部郭清術 / センチネルリンパ節 / センチネルリンパ節概念 / サイトケラチン免疫染色 / CK17 / 生検 / 舌扁平上皮癌 / 頸部郭清
Research Abstract

In oral cancer, abbreviation of elective neck dissection contributes to advancement of patients' QOL, because neck dissection for cervical lymph node metastasis causes functional and esthetic sequela.
Sentinel lymph node (SN) is defined as the first lymph node in a regional lymphatic basin that receives the lymph flow from a primary tumor (SN concept). The purpose of SN biopsy combined with lymphoscintigraphy is making a diagnosis on metastasis in regional cervical lymph nodes. It has not been clear yet whether SN concept consist in oral cancer.
We investigated the validity of SN concept in oral cancer, performed the sentinel lymph node navigation surgery, and discussed some problems about this concept.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (17 results)

All 2004 2003 2002 Other

All Journal Article (15 results) Publications (2 results)

  • [Journal Article] 口腔扁平上皮癌におけるヘパラナーゼの発現と頸部リンパ節転移の関連について2004

    • Author(s)
      生田 稔
    • Journal Title

      頭頸部腫瘍 30

      Pages: 20-24

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 口腔癌におけるセンチネルリンパ節と微小転移2004

    • Author(s)
      長谷川正午
    • Journal Title

      口腔病学会雑誌 71

      Pages: 40-40

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Correlation between heparanase mRNA expression and lymph node metastasis in oral squamous cell carcinoma.2004

    • Author(s)
      M Ikuta, H Harada, H Kurokawa, K Omur, M Yanagishita
    • Journal Title

      Head and Neck Cancer 30(1)

      Pages: 20-24

    • NAID

      10012914865

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Sentinel lymph node and micro metastasis in oral cancer2004

    • Author(s)
      Shogo Hasegawa, Ken Omura
    • Journal Title

      J.StomatoL Soc., Jpn. 71(1)

      Pages: 40-40

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 口腔癌におけるセンチネルリンパ節と微小転移2004

    • Author(s)
      長谷川 正午, 小村 健
    • Journal Title

      口腔病学会雑誌 70・1

      Pages: 40-40

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Heme oxygenase-1 expression predicts cervical lymph node metastasis of tongue squamous cell carcinomas2004

    • Author(s)
      Yanagawa T, Omura K, Harada H, Nakaso K, Iwasa S, Koyama Y, Onizawa K, Yusa H, Yoshida H.
    • Journal Title

      Oral Oncology 40・1

      Pages: 21-27

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 口腔扁平上皮癌におけるヘパラナーゼの発現と頸部リンパ節転移の関連について2004

    • Author(s)
      生田 稔, 原田浩之, 黒川 仁, 小村 健, 柳下正樹
    • Journal Title

      頭頸部腫瘍 30・1

      Pages: 20-24

    • NAID

      10012914865

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Reverse transcription-polymerase chain reaction assay for multiple mRNA tumor markers in the detection of micrometastasis of the lymph node in oral cancer.2003

    • Author(s)
      S Hasegawa
    • Journal Title

      Oral oncology 9

      Pages: 247-252

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Reverse transcription-polymerase chain reaction assay for multiple mRNA tumor markers in the detection of micrometastasis of the lymph node in oral cancer.2003

    • Author(s)
      S Hasegawa, K Omura, Y Yoshida, H Tomioka, M Ikuta, H Harada, S Mogi, K Nagumo, N Okada
    • Journal Title

      Oral oncology 9

      Pages: 247-252

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Sentinel node localization in oral tongue carcinoma.2002

    • Author(s)
      H Harada
    • Journal Title

      MONDUZZI EDITORE, MEDIMOND Inc.

      Pages: 89-93

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Will subareolar injection be a standard technique for sentinel lymphnode biopsy?2002

    • Author(s)
      K Yoshida
    • Journal Title

      Breast Cancer 9(4)

      Pages: 301-305

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 舌扁平上皮癌の頸部非制御に関与する因子 ー頸部転移様相からー2002

    • Author(s)
      原田浩之
    • Journal Title

      日本口腔外科学会雑誌 48

      Pages: 301-305

    • NAID

      10010692732

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Sentinel node localization in oral tongue carcinoma.2002

    • Author(s)
      H Harada, K Omura, H Shimamoto
    • Journal Title

      MONDUZZI EDITORE (MEDIMOND Inc)

      Pages: 89-93

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Will subareolar injection be a standard technique for sentinel lymph node biopsy?2002

    • Author(s)
      K Yoshida, N Yamamoto, N Imanaka, T Togawa, M Miyauchi, M Miyazaki
    • Journal Title

      Breast Cancer 9(4)

      Pages: 319-322

    • NAID

      50000695298

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Risk factors for neck failure in patients with squamous cell carcinoma of the tongue -Analysis of the pattern of cervical lymph node metastasis-2002

    • Author(s)
      Hiroyuki Harada, Ken Omura, Akiyuki Maeda
    • Journal Title

      Jpn.J.Oral Maxillofac.Surg. 48(6)

      Pages: 301-305

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] H.Harada, K.Omura, H.Shimamoto: "Sentinel node localization in oral tongue carcinoma"5^<th> Asian Conference on Oral and Maxillofacial Surgery. 89-93 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hasegawa S., Omura K., Yoshida Y., Tomioka H., Harada H., et al.: "Reverse transcription-polymerase chain reaction assay for multiple mRNA tumor markers in the detection of micrometastasis of the sentinel lymph node in oral cancer"Oral Oncology. IX. 247-252 (2003)

    • Related Report
      2003 Annual Research Report

URL: 

Published: 2002-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi