| Project/Area Number |
14370691
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
矯正・小児・社会系歯学
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ONO Takashi Graduate School, Tokyo Medical and Dental University, Maxillofacial Orthognathics, Lecturer, 大学院・医歯学総合研究科, 講師 (30221857)
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Eiichi Tokushima University, Maxillofacial Radiology, Professor, 大学院・ヘルスバイオサイエンス研究部, 教授 (30192321)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2003: ¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 2002: ¥7,800,000 (Direct Cost: ¥7,800,000)
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| Keywords | cleft lip and palate / MRI movie / articulation / functional magnetic resonance imaging / brain activation / plasticity / primary sensorimotor cortex / oropharyngeal structures / 代償性生活 / 構音器官 / 言語障害 / 口唇 / 口蓋 / fMRI / 一次感覚運動野 |
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| Research Abstract |
Subjects with cleft lip and palate (CLP) often have problematic articulators such as a stiff upper lip and uvula, congenital loss and dislocation of maxillary teeth. These factors may make the patient with CLP manage to substitute different place and manner of articulation 1101. Adaptation to impaired articulatory environment through novel strategies utilizing restricted perioral structures implicates a plasticity of central neural network. A comprehensive approach from brain function and peripheral movement is necessary to understand speech function in subjects with CLP. First, cortical representation of articulation of, bilabial, alveolar and velar consonants in subjects with CLP was studied by Lising functional magnetic resonance imaging (fMRI). Activation foci were found in the bilateral primary sensorimotor cortex (SI/MI) in all CLP subjects during articulation of /pa/, /ta/ and /ka/. The Si/MI ipsilateral to the CLP showed greater activation in patients with unilateral CLP, where
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as the SI/MI contralateral to the side, on which earlier cheiloplasty was performed, showed greater activation in the subject with bilateral CLP. The results suggest that there be a difference in the cortical consonant may activation pattern during consonant articulation, which is related to the side of CLP. Second, dynamic changes in oropharyngeal structures during the articulation of /pa/, /ta/ and /ka/ by a subject with CLP and a normal adult male volunteer were assessed by MRI movie. Different patterns were observed during articulation in the subject with CLP compared to the normal volunteer. Posterosuperior movement of the tongue and the anterior movement of the posterior pharyngeal wall were clearly visualized in the subject with CLP. Thus, MRI movie appears to be a promising tool for evaluating speech function in subjects with CLP because of its non-invasive and non-radiative nature. We are currently working on compensatory brain function that is associated with compensatory articulatory movement. Less
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