| Project/Area Number |
14370700
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
矯正・小児・社会系歯学
|
|---|
| Research Institution | Kyushu Dental College |
|---|
Principal Investigator |
TAKEHARA Tadamichi Kyushu Dental College, Department of Dentistry, Professor, 歯学部, 教授 (00038879)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ANSAI Toshihiro Kyushu Dental College, Department of Dentistry, Associate Professor, 歯学部, 助教授 (80244789)
TAKAHASHI Nobuhiro Tohoku University, Graduate School of Dentistry, Professor, 大学院・歯学研究科, 教授 (60183852)
KOSEKI Takeyoshi Tohoku University, Graduate School of Dentistry, Professor, 大学院・歯学研究科, 教授 (80291128)
|
|---|
| Project Period (FY) |
2002 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
|
| Budget Amount *help |
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 2004: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2003: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2002: ¥5,500,000 (Direct Cost: ¥5,500,000)
|
|---|
| Keywords | Dental caries / Biofilm / Microenvironment / pH / IS-FET |
|---|
| Research Abstract |
In the process of developing dental caries on tooth surfaces, characteristic patterns of mineral loss of enamel were observed ahead of collapsing the tooth surface and forming the caries cavity Although this process is affected by microenvironments around the tooth surface, it is difficult to analyze these in detail because of its size and complexity These microenvironments are considered to be determined by several factors, including the presence of microbes and saliva throughout the oral cavity. To understand the microbial factors, we analyzed the interrelationship among the microbes covering the tooth surfaces and host factors which affect the ecology of dental biofilm. Furthermore, to understand the environmental factors, we analyzed biological and physical characteristics of saliva, which play an important role in the microenvironment of the tooth surface. The secretion rates and physical properties of saliva are key factors in the nature of oral circumstances. Thus, physiological properties of saliva, such as viscosity and spinnbarkeit, were analyzed as to their relationship with the pathogenesis and physiological nature of oral cavities. Furthermore, we developed a minute device to obtain data on the microenvironment on tooth surfaces, this device being equipped with semiconductor microprobes for pH and temperature measurement. The memory of this device is sufficiently large to log environmental data for several days. It also includes a highly integrated microcontroller enabling continuous observation of the dynamism of mineral loss. Clinical application of this device to elucidate the nature of the pathogenesis of microbial biofilm will be undertaken to prevent mineral loss due to early dental caries lesions.
|
