• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of practical catalytic asymmetric processes based on binuclear metal complexes

Research Project

Project/Area Number 14370715
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

HASHIMOTO Shunichi  Hokkaido Univ., Graduate School of Pharmaceutical Silences, Professor, 大学院・薬学研究科, 教授 (80107391)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Seiichi  Hokkaido Univ., Graduate School of Pharmaceutical Silences, Associate Professor, 大学院・薬学研究科, 助教授 (90261320)
ANADA Masahiro  Hokkaido Univ., Graduate School of Pharmaceutical Silences, Instructor, 大学院・薬学研究科, 助手 (90344473)
中島 誠  北海道大学, 大学院・薬学研究科, 助教授 (50207792)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥14,400,000 (Direct Cost: ¥14,400,000)
Fiscal Year 2004: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2003: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 2002: ¥5,400,000 (Direct Cost: ¥5,400,000)
KeywordsDirhodium(II) Complexes / α-Diazocarbonyl Compounds / Catalysis / Asymmetric Reactions / Carbenes / Nitrenes / C-H Insertion Reaction / C-H Amidation Reaction / ロジウム(II)錯体 / C-Hアミド化反応 / カルボニルイリド / 1,3-双極付加環化反応
Research Abstract

1.We have found that the enantioselective intramolecular C-H insertion reaction of aryldiazoacetates catalyzed by dirhodium tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh_2(S-PTTL)_4, proceeded at -78 ℃ to provide exclusively cis-2-aryl-3-methoxycarbonyl-2,3-dihydobenzofurans in up to 94% ee.We have also found that Rh_2(S-PTTL)_4-catalyzed intramolecular C-H insertion reaction of α-diazoester gave cis-2-arylcyclopentanecarboxylate with up to 97% ee.
2.Dirhodium(II) tetrakis[N-tetrafluorophthaloyl-(S)-tert-leucinate], Rh_2(S-TFPTTL)_4, in which the phthalimido hydrogen atoms of the parent dirhodium(II) complex are substituted by fluorine atoms, dramatically enhances the reactivity and enantioselectivity (up to 97% ee) in intramolecular aromatic C-H insertion reactions of methyl 4-alkyl-2-diazo-4,4-diphenyl-3-oxopropionates. Catalysis with the use of 0.001 mol % of Rh_2(S-TFPTTL)_4 has achieved the highest turnover number (up to 98,000 with the methyl substituent) ever recorded for chiral dirhodium(II) complex-catalyzed carbene transformations, without compromising the yield or enantioselectivity. We also found that Rh_2(S-TFPTTL)_4 has been found to be well suited for enantioselective nitrene transfer reaction of silyl encl ether with [(2-nitrophenyl)sulfonylimino]phenyliodinane. The observed enantioselectivity of up to 99% ee is the highest reported to date for dirhodium(II) complex-catalyzed nitrene transformations.
3.We have found that enantioselective 1,3-dipolar cycloaddition of the keto-carbonyl ylide with aromatic aldehyde has been effected with the aid of Rh_2(S-BPTV)_4, affording cycloadducts with perfect exo-selectivity and enantioselectivities in excess of 92%. We also found that cycloaddition of keto-carbonyl ylide derived from α-diazo-β-ketoester with ethynylarenes under the influence of Rh_2(S-TCPTTL)_4 afforded cycloadduct in 97% ee.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (52 results)

All 2005 2004 2003 2002 Other

All Journal Article (40 results) Publications (12 results)

  • [Journal Article] Chiral Phosphine Oxide BINAPO as a Catalyst for Enantioselective Allylation of Aldehydes with Allyltrichlorosilanes2005

    • Author(s)
      M.Nakajima et al.
    • Journal Title

      Tetrahedron Letters 46

      Pages: 157-159

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Direct and Stereoselective Synthesis of 2-Acetamido-2-deoxy-β-D-glycopyranosides by Using the Phosphite Method2005

    • Author(s)
      R.Arihara et al.
    • Journal Title

      Angewandte Chemie International Edition 44

      Pages: 2245-2249

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C2005

    • Author(s)
      S.Nakamura
    • Journal Title

      Chemical & Pharmaceutical Bulletin 53

      Pages: 1-10

    • NAID

      10016651170

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Chiral Phosphine Oxide BINAPO as a Catalyst for Enantioselective Allylation of Aldehydes with Allyltrichlorosilanes2005

    • Author(s)
      M.Nakajima et al.
    • Journal Title

      Tetrahedron Letters 46-1

      Pages: 157-159

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Direct and Stereoselective Synthesis of 2-Acetamido-2-deoxy-β-D-glycopyranosides by Using the Phosphite Method2005

    • Author(s)
      R.Arihara et al.
    • Journal Title

      Angewandte Chemie International Edition 44-15

      Pages: 2245-2249

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C2005

    • Author(s)
      S.Nakamura
    • Journal Title

      Chemical & Pharmaceutical Bulletin 53-1

      Pages: 1-10

    • NAID

      10016651170

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Direct and Stereoselective Synthesis of 2-Acetamido-2-deoxy-β-D-glycopyranosides by Using the Phosphite Method2005

    • Author(s)
      R.Arihara et al.
    • Journal Title

      Angew.Chem.Int.Ed. 44(発表予定)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Enantioselective Aldol Reactions of Trichlorosilyl Enol Ethers Catalyzed by Chiral N,N'-Dioxides and Monodentate N-Oxides2004

    • Author(s)
      M.Nakajima et al.
    • Journal Title

      Tetrahedron Letters 45

      Pages: 61-64

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] A New Dirhodium(II) Carboxamidate Complex as a Chiral Lewis Acid Catalyst for Enantioselective Hetero-Diels-Alder Reactions2004

    • Author(s)
      M.Anada et al.
    • Journal Title

      Angewandte Chemie International Edition 43

      Pages: 2665-2668

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Enantioselective Aldol Reaction of Trimethoxysilyl Enol Ether Catalyzed by Lithium Binaphtholate2004

    • Author(s)
      M.Nakajima et al.
    • Journal Title

      Organic Letters 6

      Pages: 3763-3765

    • NAID

      130006997193

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] A highly stereoselective construction of 1,2-trans-β-glycosidic linkages capitalizing on 2-azido-2-deoxy-D-glycosyl diphenyl phosphates as glycosyl donors2004

    • Author(s)
      T.Tsuda et al.
    • Journal Title

      Tetrahedron 60

      Pages: 10711-10737

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Enantioselective Aldol Reactions of Trichlorosilyl Enol Ethers Catalyzed by Chiral N,N'-Dioxides and Monodentate N-Oxides2004

    • Author(s)
      M.Nakajima et al.
    • Journal Title

      Tetrahedron Letters 45-1

      Pages: 61-64

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A New Dirhodium(II) Carboxamidate Complex as a Chiral Lewis Acid Catalyst for Enantioselective Hetero-Diets-Alder Reactions2004

    • Author(s)
      M.Anada et al.
    • Journal Title

      Angewandte Chemie International Edition 43-20

      Pages: 2665-2668

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Enantioselective Aldol Reaction of Trimethoxysilyl Enol Ether Catalyzed by Lithium Binaphtholate2004

    • Author(s)
      M.Nakajima et al.
    • Journal Title

      Organic Letters 6-21

      Pages: 3763-3765

    • NAID

      130006997193

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A highly stereoselective construction of 1,2-trans-β-glycosidic linkages capitalizing on 2-azido-2-deoxy-D-glycosyl diphenyl phosphates as glycosyl donors2004

    • Author(s)
      T.Tsuda et al.
    • Journal Title

      Tetrahedron 60-47

      Pages: 10711-10737

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A New Dirhodium(II) Carboxamidate Complex as a Chiral Lewis Acid Catalyst for Enantioselective Hetero-Diels-Alder Reactions2004

    • Author(s)
      M.Anada et al.
    • Journal Title

      Angew.Chem.Int.Ed. 43

      Pages: 2665-2668

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A Highly Stereoselective Synthesis of the C10-C31 (BCDEF Ring) Portion of Pinnatoxin A2003

    • Author(s)
      S.Nakamura et al.
    • Journal Title

      Tetrahedron 58

      Pages: 10375-10386

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Direct and Stereoselective Construction of β-Mannosidic Linkages Capitalizing on 4,6-O-Benzylidene-protected D-Mannopyranosyl Diethyl Phosphite2003

    • Author(s)
      T.Tsuda et al.
    • Journal Title

      Heterocycles 59

      Pages: 509-515

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Dirhodium(II) Tetrakis[N-tetrafluorophthaloyl-(S)-tert-leucinate] : an Exceptionally Effective Rh(II) Catalyst for Enantiotopically Selective Aromatic C-H Insertions of Diazo Ketoesters2003

    • Author(s)
      H.Tsutsui et al.
    • Journal Title

      Tetrahedron : Asymmetry 14

      Pages: 817-821

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A Stereocontrolled Construction of 2-Azido-2-deoxy-1,2-trans-β-glycosidic Linkages Utilizing 2-Azido-2-deoxyglycopyranosyl Diphenyl Phosphates2003

    • Author(s)
      M.Nakajima
    • Journal Title

      Tetrahedron Letters 44

      Pages: 6453-6456

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Chiral N-Oxides as Catalysts or Ligands in Enantioselective Reactions2003

    • Author(s)
      M.Nakajima et al.
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan 61

      Pages: 1081-1087

    • NAID

      10011908443

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C by a Carbonyl Ylide Cycloaddition Strategy2003

    • Author(s)
      S.Nakamura et al.
    • Journal Title

      Angewandte Chemie International Edition 42

      Pages: 5351-5355

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Synthesis and Evaluation of Novel Dirhodium(II) Carboxylate Catalysts with Atropisomeric Biaryl Backbone2003

    • Author(s)
      K.Hikichi et al.
    • Journal Title

      Heterocycles 61

      Pages: 391-402

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Direct and Stereoselective Construction of β-Mannosidic Linkages Capitalizing on 4,6-Ο-Benzylidene-protected D-Mannopyranosyl Diethyl Phosphite2003

    • Author(s)
      T.Tsuda et al.
    • Journal Title

      Heterocycles 59-2

      Pages: 509-515

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Dirhodium(II) Tetrakis[N-tetrafluorophthaloyl-(S)-tert-leucinate] : an Exceptionally Effective Rh(II) Catalyst for Enantiotopically Selective Aromatic C-H Insertions of Diazo Ketoesters2003

    • Author(s)
      H.Tsutsui et al.
    • Journal Title

      Tetrahedron : Asymmetry 14-7

      Pages: 817-821

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Chiral N-Oxides as Catalysts or Ligands in Enantioselective Reactions2003

    • Author(s)
      M.Nakajima
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan 61-11

      Pages: 1081-1087

    • NAID

      10011908443

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Enantioselective Michael Additions of β-Keto Esters to α,β-Unsaturated Carbonyl Compounds Catalyzed by a Chiral Biquinoline N,N'-Dioxide-scandium Trifluoromethanesulfonate Complex2003

    • Author(s)
      M.Nakajima et al.
    • Journal Title

      Tetrahedron 59-37

      Pages: 7307-7313

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C by a Carbonyl Ylide Cycloaddition Strategy2003

    • Author(s)
      S.Nakamura et al.
    • Journal Title

      Angewandte Chemie International Edition 42-43

      Pages: 5351-5355

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Synthesis and Evaluation of Novel Dirhodium(II) Carboxylate Catalysts with Atropisomeric Biaryl Backbone2003

    • Author(s)
      K.Hikichi et al.
    • Journal Title

      Heterocycles 61-1

      Pages: 391-402

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Enantio- and Diastereoselective Synthesis of cis-2-Aryl-3-methoxycarbonyl-2,3-dihydro-benzofurans via the Rh(II)-Catalyzed C-H Insertion Process2002

    • Author(s)
      H.Saito et al.
    • Journal Title

      Organic Letters 4

      Pages: 3887-3890

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Selective Synthesis of Optically Active Allenic and Homopropargylic Alcohols from Propargyl Chloride2002

    • Author(s)
      M.Nakajima et al.
    • Journal Title

      Tetrahedron : Asymmetry 13

      Pages: 2449-2452

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Enantioselective Ring Opening of meso-Epoxides with Tetrachlorosilane Catalyzed by Chiral Bipyridine N,N'-Dioxide Derivatives2002

    • Author(s)
      M.Nakajima et al.
    • Journal Title

      Tetrahedron Letters 43

      Pages: 8827-8829

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Dirhodium(II) Tetrakis[N-tetrachlorophthaloyl-(S)-tert-leucinate] : a New Chiral Rh(II) Catalyst for Enantioselective Amidation of C-H Bonds2002

    • Author(s)
      M.Yamawaki et al.
    • Journal Title

      Tetrahedron Letters 43

      Pages: 9561-9564

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Studies Directed toward the Total Synthesis of Pinnatoxin A : Synthesis of the 6,5,6-Dispiroketal (BCD Ring) System by Double Hemiketal Formation/Hetero-Michael Addition Strategy2002

    • Author(s)
      S.Nakamura et al.
    • Journal Title

      Tetrahedron 58

      Pages: 10353-10374

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Enantio-and Diastereoselective Synthesis of cis-2-Aryl-3-methoxycarbonyl-2,3-dihydrobenzofurans via the Rh(II)-Catalyzed C-H Insertion Process2002

    • Author(s)
      H.Saito et al.
    • Journal Title

      Organic Letters 4-22

      Pages: 3887-3890

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Selective Synthesis of Optically Active Allenic and Homopropargylic Alcohols from Propargyl Chloride2002

    • Author(s)
      M.Nakajima et al.
    • Journal Title

      Tetrahedron : Asymmetry 13-22

      Pages: 2449-2452

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Enantioselective Ring Opening of meso-Epoxides with Tetrachiorosilane Catalyzed by Chiral Bipyridine N,N'-Dioxide Derivatives2002

    • Author(s)
      M.Nakajima et al.
    • Journal Title

      Tetrahedron Letters 43-49

      Pages: 8827-8829

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Dirhodium(II) Tetrakis[N-tetrachlorophthaloyl-(S)-tert-leucinate] : a New Chiral Rh(II) Catalyst for Enantioselective Amidation of C-H Bonds2002

    • Author(s)
      M.Yamawaki et al.
    • Journal Title

      Tetrahedron Letters 43-52

      Pages: 9561-9564

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Studies Directed toward the Total Synthesis of Pinnatoxin A : Synthesis of the 6,5,6-Dispiroketal (BCD Ring) System by Double Hemiketal Formation/Hetero-Michael Addition Strategy2002

    • Author(s)
      S.Nakamura et al.
    • Journal Title

      Tetrahedron 58-52

      Pages: 10353-10374

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A Highly Stereoselective Synthesis of the C10-C31 (BCDEF Ring) Portion of Pinnatoxin A2002

    • Author(s)
      S.Nakamura et al.
    • Journal Title

      Tetrahedron 58-52

      Pages: 10375-10386

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] H.Tsustui et al.: "Dirhodium(II) Tetrakis [N-tetrafluorophthaloyl-(S)-tert-leucinate] : an Exceptionally Effective Rh(II) Catalyst for Enantiotopically Selective Aromatic C-H Insertions of Diazo Ketoesters"Tetrahedron : Asymmetry. 14. 817-821 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Nakajima et al.: "Enantioselective Michael Additions of β-Keto Esters to α,β-Unsaturated Carbonyl Compounds Catalyzed by a Chiral Biquinoline N, N'-Dioxide-scandium Trifluoromethanesulfonate Complex"Tetrahedron. 59. 7307-7313 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Hikichi et al.: "Synthesis and Evaluation of Novel Dirhodium(II) Carboxylate Catalysts with Atropisomeric Biaryl Backbone"Heterocycles. 61. 391-401 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Nakamura et al.: "Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C via a Carbonyl Ylide Cycloaddition Strategy"Angewandte Chemie International Edition. 42. 5351-5355 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Tsuda et al.: "A Stereocontrolled Construction of 2-Azido-2-deoxy-1,2-trans-β-glycosidic Linkages Utilizing 2-Azido-2-deoxyglycopyranosyl Diphenyl Phosphates"Tetrahedron Letters. 44. 6453-6456 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Anada et al.: "A New Dirhodium(II) Carboxamidate Complex as a Chiral Lewis Acid Catalyst for Enantioselective Hetero-Diels-Alder Reactions"Angewandte Chemie international Edition. (発表予定).

    • Related Report
      2003 Annual Research Report
  • [Publications] H.Saito et al.: "Enantio-and Diastereoselective Synthesis of cis-2-Aryl-3-methoxycarbonyl-2,3-dihydrobenzofurans via the Rh(II)-Catalyzed C-H Insertion Process"Organic Letters. 4. 3887-3890 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Nakajima et al.: "Selective Synthesis of Optically Active Allenic and Homopropargylic Alcohols from Propargyl Chloride"Tetrahedron : Asymmetry. 13. 2449-2452 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Nakajima et al.: "Enantioselective Ring Opening of meso-Epoxides with Tetrachlorosilane Catalyzed by Chiral Bipyridine N, N'-Dioxide Derivatives"Tetrahedron Letters. 43. 8827-8829 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Yamawaki et al.: "Dirhodium(II) Tetrakis[N-tetrachlorophthaloyl-(S)-tert-leucinate] : a New Chiral Rh(II) Catalyst for Enantioselective Amidation of C-H Bonds"Tetrahedron Letters. 43. 9561-9564 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Nakamura et al.: "Studies Directed toward the Total Synthesis of Pinnatoxin A : Synthesis of the 6,5,6-Dispiroketal (BCD Ring) System by Double Hemiketal Formation/Hetero-Michael Addition Strategy"Tetrahedron. 58. 10353-10374 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Nakamura et al.: "A Highly Stereoselective Synthesis of the C10-C31(BCDEF Ring) Portion of Pinnatoxin A"Tetrahedron. 58. 10375-10386 (2002)

    • Related Report
      2002 Annual Research Report

URL: 

Published: 2002-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi