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Development of myoblast transplantation combined with gene therapy to treat dilated eardiomyopathy

Research Project

Project/Area Number 14370774
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human genetics
Research InstitutionNiigata University

Principal Investigator

KAWADA Tomie  Niigata University, Medical and Dental Hospital, Associate professor, 医歯学総合病院, 助教授 (00186107)

Co-Investigator(Kenkyū-buntansha) SATOH Hiroshi  Niigata University, Medical and Dental Hospital, Professor, 医歯学総合病院, 教授 (10125768)
NAKAZAWA Mikio  Niigata University, Faculty of Medicine, Professor, 医学部, 教授 (80143759)
TOYO-OKA Teruhiko  Tokyo University Hospital, Faculty of Medicine, Professor, 医学部, 教授 (00146151)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2004: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2003: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 2002: ¥2,800,000 (Direct Cost: ¥2,800,000)
Keywordscell transplantation / dilated cardiomyopathy / myoblast / cardiomyopathy hamster / myosine heavy chain / gene therapy / connexin-43 / 重症心不全 / δ-サルコグリガン / アデノ随伴ウイルス / δ-サルコグリカン / アデノ随伴ウイルスベクター
Research Abstract

The prognosis of patients with dilated eardiomyopathy(DCM) is still poor and cardiac transplantation is the most life-saving treatment in the advances cases. Cell transplantation is currently gaining evidence as a potential means of improving the prognosis of patients with heart failure. To treat DCM, we transplanted normal skeletal myoblast(SkM), to TO-2 strain hamsters, a representative model of human hereditary DCM, of which δ-sarcoglycan(SG) gene is deleted. We confirmed no rejection between TO-2 and golden hamsters by interchanging skin graft in the pilot study. SkM were isolated from the limbs of 3 weeks old normal golden hamsters. We transplanted SkM leveled to 5 weeks old TO-2 hearts. 4',6-Diamidino-2-phenylindole, dihydrochloride(DAPI) was used for nucleus staining, and 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate(DiI) was used for cell membrane staining. At 5 weeks after SkM transplantation, fast skeletal muscle type of skeletal muscle myosin heavy chain(fast-MHC) was detected by Western blotting analysis. DAPI and DiI positive cells were clearly detected in the left ventricle in the grafted TO-2. δ-SG, fast-and slow-MHC were immunologically stained in the grafted TO-2 hearts, but not in the control TO-2 hearts. Moreover, connexin-43 was expressed on the interface of cells that expressed δ-SG. These results suggest that SkM were successfully allografted to DCM hamster. These methods would provide a new strategy for the treatment of DCM.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report

Research Products

(86 results)

All 2005 2004 2003 2002 Other

All Journal Article (78 results) Book (1 results) Publications (7 results)

  • [Journal Article] A novel paradigm for therapeutic basis of advanced heart failure-Assessment by gene therapy-.2005

    • Author(s)
      Kawada T.
    • Journal Title

      Pharmacology & Therapeutics (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel scheme of dystrophin disruption for the progression of advanced heart failure.2005

    • Author(s)
      Kawada T.
    • Journal Title

      Biochimica et Biophysica Acta (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel paradigm for the therapeutic basis of advanced heart failure-Assessment by gene therapy.2005

    • Author(s)
      T.Kawada
    • Journal Title

      Pharmacol. & Therap. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mini rreview-A novel scheme of dystrophin disruption for the progression of advanced heart failure.2005

    • Author(s)
      T.Kawada
    • Journal Title

      Biochirnica et Biophysica (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel paradigm for therapeutic basis of advanced heart failure-Assessment by gene therapy-.2005

    • Author(s)
      T.Kawada.
    • Journal Title

      Pharmacology & Therapeutics (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A novel scheme of dystrophin disruption for the progression of advanced heart failure.2005

    • Author(s)
      T.Kawada
    • Journal Title

      Biochimica et Biophysica Acta (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of ACE inhibitor and AT1 blocker on dystrophin-related proteins and calpain in failing heart.2004

    • Author(s)
      Takahashi M.
    • Journal Title

      Cardiovascular Research 65

      Pages: 356-365

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Translocation and cleavage of myocardial dystrophin as a common pathway to advanced heart failure : a scheme for the progression of cardiac dysfunction.2004

    • Author(s)
      Toyo-oka T.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 101

      Pages: 7381-7385

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells.2004

    • Author(s)
      Ma J.
    • Journal Title

      European J Pharmacology 505

      Pages: 67-74

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] RNAi induction and activation in mammalian muscle cells where Dicer and eIF2C translation initiation factors are barely expressed.2004

    • Author(s)
      Sago N.
    • Journal Title

      Biochemical Biophysical Research Communication 319

      Pages: 50-57

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of pranidipine, a novel calcium channel antagonist, on the progression of left ventricular dysfunction and remodeling in rats with heart failure.2004

    • Author(s)
      MI.Wahed
    • Journal Title

      Pharmacology 72

      Pages: 26-32

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] 心不全の重症化機構-その新しい概念-2004

    • Author(s)
      河田登美枝
    • Journal Title

      日本薬理学雑誌 123

      Pages: 55-63

    • NAID

      10013514023

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] MUCHA Investigators, Low-dose carvedilol improves left ventricular function and reduces cardiovascular hospitalization in Japanese patients with chronic heart failure : the Multicenter Carvedilol Heart Failure Dose Assessment (MUCHA) trial.2004

    • Author(s)
      M.Hori
    • Journal Title

      Am.Heart J. 147

      Pages: 324-330

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] MUCHA Investigators. Low-dose carvedilol improves left ventricular function and reduces cardiovascular hospitalization in Japanese patients with chronic heart failure : the Multicenter Carvedilol Heart Failure Dose Assessment(MUCHA) trial.2004

    • Author(s)
      M.Hori
    • Journal Title

      Am Heart J. 147

      Pages: 324-330

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A new paradigm for the progression of advanced heart failure.2004

    • Author(s)
      T.Kawada
    • Journal Title

      Folia Pharmacol.Jpn. 123

      Pages: 55-63

    • NAID

      10013514023

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Translocation and cleavage of myocardial dystrophin as a common pathway to advanced heart failure : a scheme for the progression of cardiac dysfunction.2004

    • Author(s)
      T.Toyo-Oka
    • Journal Title

      Proc Natl Acad Sci USA. 101

      Pages: 7381-7385

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] RNAi induction and activation in mammalian muscle cells where Dicer and eIF2C translation initiation factors are barely expressed.2004

    • Author(s)
      N.Sago
    • Journal Title

      Biochem Biophys Res Commun. 319

      Pages: 50-57

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of pranidipine, a novel calcium channel antagonist, on the progression of left ventricular dysfunction and remodeling in rats with heart failure.2004

    • Author(s)
      MI.Wahed
    • Journal Title

      Pharmacology. 72

      Pages: 26-32

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells.2004

    • Author(s)
      J.Ma
    • Journal Title

      Eur J Pharmacol 505

      Pages: 67-74

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of ACE inhibitor and ATI blocker on dystrophin-related proteins and calpain in failing heart.2004

    • Author(s)
      M.Takahashi
    • Journal Title

      Cardiovasc Res. 65

      Pages: 356-365

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of ACE inhibitor and AT1 blocker on dystrophin-related proteins and calpain in failing heart.2004

    • Author(s)
      T.Takahashi
    • Journal Title

      Cardiovascular Research 65101

      Pages: 356-365

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Transdocation and cleavage of myocardial dystrophin as a common pathway to advanced heart failure : a scheme for the progression of cardiac dysfunction.2004

    • Author(s)
      T.Toyo-oka
    • Journal Title

      Proc.Natl.Acad.Sci.U S A 101

      Pages: 7381-7385

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells.2004

    • Author(s)
      J.Ma
    • Journal Title

      European J Pharmacology 505

      Pages: 67-74

    • Related Report
      2004 Annual Research Report
  • [Journal Article] RNAi induction and activation in mammalian muscle cells where Dicer and IF2C translation initiation factors are barely expressed.2004

    • Author(s)
      N.Sago
    • Journal Title

      Biochemical Biophysical Research Communication 319

      Pages: 50-57

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Sarcolemmal fragility secondary to the degradation of dystrophin in dilated cardiomyopathy, as estimated by electron microscopy.2003

    • Author(s)
      T.Kawada
    • Journal Title

      Exp.Clin.Cardiol. 8

      Pages: 67-70

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparative effects of perindopril with enalapril in rats with dilated cardiomyopathy.2003

    • Author(s)
      K.Watanabe
    • Journal Title

      J.Cardiovasc.Pharmacol. 42(suppl1)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] High fidelity SNP genotyping using sequence-specific primer elongation and fluorescence correlation spectroscopy.2003

    • Author(s)
      K.Hori
    • Journal Title

      Curr.Pharm.Biotechnol. 4

      Pages: 477-484

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Inhibition of hydroxymethylglutaryl-coenzyme a reductase reduces Th1 development and promotes Th2 development.2003

    • Author(s)
      R.Hakamada-Taguchi
    • Journal Title

      Circ.Res. 93

      Pages: 948-956

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of imidapril and TA-606 on rat dilated cardiomyopathy after myocarditis.2003

    • Author(s)
      T.Kashimura
    • Journal Title

      Jpn.Heart J. 44

      Pages: 753-744

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Quinapril inhibits progression of heart failure and fibrosis in rats with dilated cardiomyopathy after myocarditis.2003

    • Author(s)
      W.Juan
    • Journal Title

      Mol.Cell Biochem. 251

      Pages: 77-82

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Targeting of iNOS with antisense DNA plasmid reduces cytokine-induced inhibition of osteoblastic activity.2003

    • Author(s)
      T.Abe
    • Journal Title

      Am.J.Physiol.Endocrinol.Metab. 285

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Decrease in sarcoglycans and dystrophin in failing heart following acute myocardial infarction.2003

    • Author(s)
      H.Yoshida
    • Journal Title

      Cardiovasc.Res. 59

      Pages: 419-427

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Assessment of affinities and dissociation potencies of several 5-HT_2 antagonists to and from M2 muscarinic receptor in rat heart membranes.2003

    • Author(s)
      M.Rashid
    • Journal Title

      Biol.Pharm.Bull. 26

      Pages: 1184-1187

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Insurmountable antagonism of AT-1015, a 5-HT2 antagonist, on serotonin-induced endothelium-dependent relaxation in porcine coronary artery.2003

    • Author(s)
      M.Rashid
    • Journal Title

      J.Pharm.Pharmacol. 55

      Pages: 827-832

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] FR167653 suppresses the progression of experimental autoimmune myocarditis.2003

    • Author(s)
      S.Maruyama
    • Journal Title

      Mol.Cell Biochem. 246

      Pages: 39-44

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of the anti-platelet aggregation drug dilazep on cognitive function in Dahl salt-sensitive rats.2003

    • Author(s)
      A.Numabe
    • Journal Title

      Hypertens.Res. 26

      Pages: 185-191

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 拡張型心筋症の遺伝子治療-その現状と未来-2003

    • Author(s)
      豊岡照彦
    • Journal Title

      Cardiac Practice 14

      Pages: 171-180

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 責任遺伝子導入による心筋再生治療2003

    • Author(s)
      河田登美枝
    • Journal Title

      循環器科 53

      Pages: 429-437

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cell density and growth-dependent down-regulation of both intracellular calcium responses to agonist stimuli and expression of smooth-surfaced endoplasmic reticulum in MC3T3-E1 osteoblast-like cells.2003

    • Author(s)
      T.Koizumi
    • Journal Title

      J.Biol.Chem. 278

      Pages: 6433-6439

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Betaxolol improves the survival rate and changes natriuretic peptide expression in rats with heart failure.2003

    • Author(s)
      K.Watanabe
    • Journal Title

      J.Cardiovasc.Pharmacol. 41(Suppl 1)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparative effects of angiotensin II receptor blockade (candesartan) with angiotensin-converting enzyme inhibitor (quinapril) in rats with dilated cardiomyopathy.2003

    • Author(s)
      K.Watanabe
    • Journal Title

      J.Cardiovasc.Pharmacol. 41(Suppl)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Angiotensin II type 1 receptor blocker, valsartan, prevented cardiac fibrosis in rat cardiomyopathy after autoimmune myocarditis.2003

    • Author(s)
      H.Tachikawa
    • Journal Title

      J.Cardiovasc.Pharmacol. 41(Suppl 1)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Angiotensin II type 1 receptor blocker, valsartan, prevented cardiac fibrosis in rat cardiomyopathy after autoimmune myocarditis.2003

    • Author(s)
      H.Tachikawa
    • Journal Title

      J Cardiovasc Pharmacol. 41 Suppl 1

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparative effects of angiotensin II receptor blockade (candesartan) with angiotensin-converting enzyme inhibitor (quinapril) in rats with dilated cardiomyopathy.2003

    • Author(s)
      K.Watanabe
    • Journal Title

      J Cardiovasc Pharmacol. 41 Suppl 1

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Betaxolol improves the survival rate and changes natriuretic peptide expression in rats with heart failure.2003

    • Author(s)
      K.Watanabe
    • Journal Title

      J Cardiovasc Pharmacol. 41 Suppl 1

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cell density and growth-dependent down-regulation of both intracellular calcium responses to agonist stimuli and expression of smooth-surfaced endoplasmic reticulum in MC3T3-E1 osteoblast-like cells.2003

    • Author(s)
      T.Koizumi
    • Journal Title

      J Biol Chem. 21;278

      Pages: 6433-6439

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of the anti-platelet aggregation drug dilazep on cognitive function in Dahl salt-sensitive rats.2003

    • Author(s)
      A.Numabe
    • Journal Title

      Hypertens Res. 26

      Pages: 185-191

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] FR167653 suppresses the progression of experimental autoimmune myocarditis.2003

    • Author(s)
      S.Maruyama
    • Journal Title

      Mol Cell Biochem. 246

      Pages: 39-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Somatic gene transfer for the rescue of dilated cardiomyopathy.2003

    • Author(s)
      T.Kawada
    • Journal Title

      Cardioangiology 53

      Pages: 429-437

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Insurmountable antagonism of AT-1015,a 5-HT2 antagonist, on serotonin-induced endothelium-dependent relaxation in porcine coronary artery.2003

    • Author(s)
      M.Rashid
    • Journal Title

      J Pharm Pharmacol. 55

      Pages: 827-827

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Assessment of affinities and dissociation potencies of several 5-HT2 antagonists to and from M2 muscarimc receptor in rat heart membranes.2003

    • Author(s)
      M.Rashid
    • Journal Title

      Biol Pharm Bull. 26

      Pages: 1184-1187

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Decrease in sarcoglycans and dystrophin in failing heart following acute myocardial infarction.2003

    • Author(s)
      H.Yoshida
    • Journal Title

      Cardiovasc Res. 59

      Pages: 419-427

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Targeting of iNOS with antisense DNA plasmid reduces cytokine-induced inhibition of osteoblastic activity.2003

    • Author(s)
      T.Abe
    • Journal Title

      Am J Physiol Endocrinol Metab. 285

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Quinapril inhibits progression of heart failure and fibrosis in rats with dilated cardiomyopathy after myocarditis.2003

    • Author(s)
      W.Juan
    • Journal Title

      Mol Cell Biochem. 251

      Pages: 77-82

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of imidapril and TA-606 on rat dilated cardiomyopathy after myocarditis.2003

    • Author(s)
      T.Kashimura
    • Journal Title

      Jpn Heart J. 44

      Pages: 735-744

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Inhibition of hydroxymethylglutaryl-coenzyme a reductase reduces Th1 development and promotes Tn2 development.2003

    • Author(s)
      R.Hakamada-Taguchi
    • Journal Title

      Circ Res. 93

      Pages: 948-956

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] High fidelity SNP genotyping using sequence-specific primer elongation and fluorescence correlation spectroscopy.2003

    • Author(s)
      Y.Uehara
    • Journal Title

      Curr Pharm Biotechnol. 4

      Pages: 477-484

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparative effects of perindopril with enalapril in rats with dilated cardiomyopathy.2003

    • Author(s)
      K.Watanabe
    • Journal Title

      J Cardiovasc Pharmacol. 42 Suppl 1

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Sarcolemmal fragility secondary to the degradation of dystrophin in dilated cardiomyopathy, as estimated by electron microscopy.2003

    • Author(s)
      T.Kawada
    • Journal Title

      Exp Clin Cardiol. 8

      Pages: 67-70

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene therapy prevents disruption of dystrophin-related proteins in a model of hereditary dilated cardiomyopathies in hamster.2002

    • Author(s)
      T.Toyo-oka
    • Journal Title

      Heart Lung & Circ. 11

      Pages: 174-181

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nonselective cation currents regulate membrane potential of rabbit coronary arterial cell : modulation by lysophosphatidylcholine.2002

    • Author(s)
      K.Terasawa
    • Journal Title

      Circulation 106

      Pages: 3113-3119

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Fenofibrate, a peroxisome proliferator-activated receptor alpha activator, suppresses experimental autoimmune myocarditis by stimulating the interleukin-10 pathway in rats.2002

    • Author(s)
      S.Maruyama
    • Journal Title

      J.Atheroscler.Thromb. 9

      Pages: 87-92

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of sarpogrelate, a novel 5-HT_2 antagonist, on 5-HT-induced endothelium-dependent relaxations in porcine coronary artery.2002

    • Author(s)
      M.Rashid
    • Journal Title

      Jpn.J.Pharmacol. 89

      Pages: 405-412

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] AT-1015, a newly synthesized 5-HT_2 receptor antagonist, dissociates slowly from the 5-HT_2 receptor sites in rabbit cerebral cortex membrane.2002

    • Author(s)
      M.Rashid
    • Journal Title

      Jpn.J.Pharmacol. 54

      Pages: 1123-1128

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The relationship between changes in normal-range systolic blood pressure and congnitive function in middle-aged healthy women.2002

    • Author(s)
      R.Hakamada-Taguchi
    • Journal Title

      Hypertens.Res. 25

      Pages: 565-569

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Endogenous prostaglandin D_2 synthesis reduces an increase in plasminogen activator inhibitor-1 following interleukin stimulation in bovine endothelial cells.2002

    • Author(s)
      H.Negoro
    • Journal Title

      J.Hypertens. 20

      Pages: 1347-1354

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Co-culture and crosstalk between endothelial cells and vascular smooth muscle cells mediated by intracellular calcium.2002

    • Author(s)
      WS.Shin
    • Journal Title

      Methods Mol.Biol. 188

      Pages: 347-357

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Vector analysis of the wall shear rate at the human aortoiliac bifurcation using cine MR velocity mapping.2002

    • Author(s)
      T.Tsuji
    • Journal Title

      AJR Am.J.Roentgenol. 178

      Pages: 995-999

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of carvedilol on cardiac function and cardiac adrenergic neuronal damage in rats with dilated cardiomyopathy.2002

    • Author(s)
      K.Watanabe
    • Journal Title

      J.Nucl.Med. 43

      Pages: 531-535

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of carvedilol on cardiac function and cardiac adrenergic neuronal damage in rats with dilated cardiomyopathy.2002

    • Author(s)
      K.Watanabe
    • Journal Title

      J Nucl Med. 43

      Pages: 531-535

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Vector analysis of the wall shear rate at the human aortoiliac bifurcation using cine MR velocity mapping.2002

    • Author(s)
      T.Tsuji
    • Journal Title

      AJR Am J.Roentgenol. 178

      Pages: 995-999

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Co-culture and crosstalk between endothelial cells and vascular smooth muscle cells mediated by intracellular calcium.2002

    • Author(s)
      WS, Shin
    • Journal Title

      Methods Mol Biol. 188

      Pages: 347-357

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Endogenous prostaglandin D2 synthesis reduces an increase in plasminogen activator inhibitor-1 following interleukin stimulation in bovine endothelial cells.2002

    • Author(s)
      H.Negoro
    • Journal Title

      J Hypertens. 20

      Pages: 1347-1354

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The relationship between changes in normal-range systolic blood pressure and cognitive function in middle-aged healthy women.2002

    • Author(s)
      R.Hakamada-Taguchi
    • Journal Title

      Hypertens Res. 25

      Pages: 565-569

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] AT-1015,a newly synthesized 5-HT2 receptor antagonist, dissociates slowly from the 5-HT2 receptor sites in rabbit cerebral cortex membrane.2002

    • Author(s)
      M.Rashid
    • Journal Title

      J Pharm Pharmacol. 54

      Pages: 1123-1128

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of sarpogrelate, a novel 5-HT2 antagonist, on 5-HT-induced endothelium-dependent relaxations in porcine coronary artery.2002

    • Author(s)
      M.Rashid
    • Journal Title

      Jpn J Pharmacol. 89

      Pages: 405-412

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Fenofibrate, a peroxisome proliferator-activated receptor alpha activator, suppresses experimental autoimmune myocarditis by stimulating the interleukin-10 pathway in rats.2002

    • Author(s)
      S.Maruyama
    • Journal Title

      J Atheroscler Thromb. 9

      Pages: 87-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nonselective cation currents regulate membrane potential of rabbit coronary arterial cell : modulation by lysophosphatidylcholine.2002

    • Author(s)
      K.Terasawa
    • Journal Title

      Circulation. 106

      Pages: 3111-3119

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Gene-based therapy of advanced heart failure secondary to the disruption of dystrophin-related proteom.2003

    • Author(s)
      T.Toyo-oka
    • Total Pages
      508
    • Publisher
      Kluwer Academic Publisher
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Kawada T.: "Sarcolemmal fragility secondary to the degradation of dystrophin in dilated cardiomyopathy, as estimated by electron microscopy"Exp.Clin.Cardiol. 8. 67-70 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 豊岡照彦: "循環器疾患と関連遺伝子,拡張型心筋症の遺伝子治療-その現状と未来-"Cardiac Practice. 14. 171-180 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 河田登美枝: "心不全の重症化機構-その新しい概念-"日本薬理学雑誌. 123. 53-62 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Toyo-oka T.: "Signal transduction and cardiac hypertrophy"Academic Publisher. 508 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kawada T.: "Rescue of hereditary dilated cardiomyopathy by rAAV-mediated somatic gene therapy"Proc. Natl. Acad. Sci. USA.. 99. 901-906 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Toyo-oka T.: "Gene therapy prevents disruption of dystrophin related proteins in a model of hereditary dilated cardiomyopathies in hamster"Heart Lung & Circ.. 11. 174-181 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 河田登美枝: "生体内心筋に対する遺伝子導入-拡張型心筋症の遺伝子治療-"日本薬理学雑誌. 119. 37-44 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-03-31   Modified: 2016-04-21  

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