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Effects of exercise during growth on the expresslon of myostatin in muscle

Research Project

Project/Area Number 14380012
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 体育学
Research InstitutionThe University of Tokyo

Principal Investigator

ISHII Naokata  The University of Tokyo, Graduate School of Arts and Science, Professor, 大学院・総合文化研究科, 教授 (20151326)

Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsMechanical unloading / Exercise / Growth stage / Mechanical environment / Muscle hypertrophy / Growth factors / Muscle satellite cell / 不活動 / 骨格筋 / ミオスタチン / マウス
Research Abstract

Exercise stimulus during growth is likely important not only for the development of various physiological functions but also for maintaining these functions throughout the later stages of life. Myostatin, a growth factor that strongly suppresses the proliferation of muscle satellite cells, decreases during growth and also as the muscle is mechanically loaded, so that it may play a part in normal development of muscle. The present study investigated the effects of either exercise or mechanical unloading during early stage of growth on the content of myostatin and the number of satellite cells within muscles during the later stages of growth. Mice (3-wk age) were assigned into control, uphill-run exercise, downhill-run exercise and unloaded groups, and subjected to either treadmill running or hindlimb suspension for 2 wk, thereafter returned to the normal in-cage activity. In all groups, the content of myostatin in gastrocnemius (GA) and soleus (SOL) muscles decreased at 5-8 wk without significant difference between groups. However, the number of satellite cells per muscle fiber was significantly smaller in unloaded group and larger in exercise groups than in control group. In unloaded group, wet weight of both muscles markedly decreased after the hindlimb suspension. Although the muscle weight was recovered at 12 wk, the number of muscle fibers was significantly smaller than in other three groups. Thus in the second part of study, the mice were hindlimb-suspended at 3-5 wk, returned to normal activity until 12 wk, and then trained with uphill running for 2wk. In both GA and SOL, however, no significant differences in muscle weight were seen between hindlimb-suspended and control groups. The results suggest that the mechanical unloading during the early stage of growth persistently impairs the normal development of muscle, but does not strongly affect the adaptability of muscle to relatively low-intensity exercise in adult.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Ishii, N.: "Factors involved in the resistance-exercise stimulus and their relations to muscular hypertrophy"Exerc.Nutr.Environmental Stress. 2. 119-138 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hosoyama, T., Ishii, N.et al.: "Molecular cloning of equine (Through bred) myostatin cDNA and detection of myostatin precursor proteins in the serum."J.Reprod.Develop.. 48. 335-342 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takarada, Y., Ishii, N.: "Muscular hypertrophy induced by low-intensity resistance training with short res C period in aged women."J.Str.Condition.Res.. 16. 123-128 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takarada, Y., Sato, Y., Ishii, N.: "Effects of resistance exercise training with vascular occlusion on muscular function in athletes."Ear.J.Appl.Physiol.. 86. 308-314 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Goto, K., Ishii, N.et al.: "Acute and long-term effects of resistance-training regimens with varicd combinations of high-and low-intensity exercises."J.Str.Condition.Res.. (In press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 石井 直方: "筋肥大のメカニズムと筋力トレーニングの接点"日本臨床スポーツ医学会誌. 11. 406-413 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishii, N.: "Factors involved in the resistance-exercise stimulus and their relations to muscular hypertrophy."Exerc.Nutr.Environmental Stress. 2. 119-138 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hosoyama, T., Kawada, S., Oshiumi, R., Yoneda, S., Soeta, C., Yamanouchi, K., Hasegawa, T., Ishida, N., Mukoyama, H., Ishji, N., Tachi,.M: "olecular cloning of Equine (Thoroughbred) myostatin cDNA and detection of myostatin precursor proteins in the serum."J.Reprod.Develop.. 48. 335-342 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takarada, Y., Ishii, N.: "Muscular hypertrophy induced by low-intensity resistance training with short rest period in aged women."J.Str.Cond.Res.. 16. 123-128 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takarada, Y., Sato, Y., Ishii, N.: "Effects of resistance exercise training with vascular occlusion on muscular function in athletes."Eur.J.Appl.Physiol.. 86. 308-314 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Goto, K., Ishii, N.et al.: "Acute and long-term effects of resistance-training regimens with varied combinations of high and low-intensity exercises."J.Str.Cond.Resr. (In press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishii, N.: "Possible innovations in resistance-exercise regimens based on the mechanisms of muscular hypertrophy. (In Japanese)"J.Clinical Sportsmed.. 11. 406-416 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takarada Y., Ishii N.: "Muscular hypertrophy induced by low-intensity resistance training with short rest period in aged women."J.Str.Condition.Res.. 16. 123-128 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takarada Y., Sato Y., Ishii N.: "Effect of resistance exercise training with vascular occlusion on muscular function in athletes."Eur.J.Appl.Physiol.. 86. 308-314 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ishii N.: "Factors involved in the resistance-exercise stimulus and their relations to muscular hypertrophy."Exerc.Nutr.Environmental Stress. 2. 119-138 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hosoyama T., Ishii N.et al.: "Molecular cloning of equine (Thoroughbred) myostatin cDNA and detection of myostatin precursor proteins in the serum."J.Reprod.Develop. 48. 335-342 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Goto K., Ishii N.et al.: "Acute and long-term effects of resistance-training regimens with varied combinations of high- and low-intensity exercises."J.Str.Condition.Res.. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 石井 直方: "筋肥大のメカニズムと筋力トレーニングの接点"日本臨床スポーツ医学会誌. 11. 406-413 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takarada, Y., Ishii, N.: "Muscular hypertrophy induced by resistance training with short rest period in aged women"Journal of Strength and Conditioning Research. 16. 123-128 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takarada, Y., Sato, Y., Ishii, N.: "Effects of resistance exercise training with vascular occlusion on muscular function in athletes"European Journal of Applied Physiology. 86. 308-314 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ishii, N.: "Factors involved in resistance-exercise stimulus and their relations to muscular hypertrophy"Exercise, Nutrition and Environmental Stress. 2. 119-138 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hosoyama, T., Kawada, S., Ishii, N., et al.: "Molecular cloning of Equine (Thoroughbred) myostatin cDNA and detection of myostatin precursor proteins in the serum"Journal of Reproduction and Development. 48. 335-342 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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