| Project/Area Number |
14380046
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
食生活
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| Research Institution | Sugiyama Jogakuen University |
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Principal Investigator |
YAMASHITA Kanae Sugiyama Jogakuen University, Department of Food and Nutrition, Professor, 生活科学部, 教授 (40080113)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Yasushi Sugiyama Jogakuen University, Department of Food and Nutrition, Assistant, 助手 (60367638)
TOHYAMA Tomoko Kinjyougakuin University, Dept. Environmental Sciences, Assistant, 生活環境学部, 助手 (00387599)
尾林 麻理子 椙山女学園大学, 生活科学部, 助手 (40350970)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 2004: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2003: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2002: ¥4,500,000 (Direct Cost: ¥4,500,000)
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| Keywords | Vitamin E / α-tocopherol / α-tocotrienol / γ-tocotrienol / sesame lignan / skin / UVB / antioxidant / 脂肪組織 / ラット / ヘアレスマウス / 血漿リポたんぱく質 / 肝臓 / ラツト |
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| Research Abstract |
It is well known that α -tocopherol has the highest vitamin E activity because it has the highest affinity with α-TTP in the liver. We found that α-tocopherol enhances the α-tocotrienol metabolism but not the γ-tocotrienol metabolism in rats. We observed that sesame seed and its lignans produced higher concentrations of vitamin E (tocopherols and tocotrienols) in the animal body. We could prove that the primary cause of high vitamin E concentrations in rats fed sesame seed is that sesame lignans inhibit the degradation of vitamin E to CEHC. We also found that tocotrienol distribution in the animal body is different from that of tocopherol, and that tocotrienol is present specifically in the skin and adipose tissues. Dietary tocotrienol accumulated in the skin prevents oxidative damage induced by UVB irradiation and is a more powerful antioxidant than α-tocopherol. Sesame seed and its lignans induce higher tocotrienol concentrations in the skin and adipose tissues, and act together with tocotrienol to prevent oxidative damage induced by UVB irradiation.
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