Mechanism and molecular basis for asymmetry formation of hippocampal synapses
| Project/Area Number |
14380355
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
SHIGEMOTO Ryuichi National Institute for Physiological Sciences, Professor, 生理学研究所, 教授 (20221294)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Isao Kyushu University, Faculty of Sciences, Associate Professor, 大学院・理学研究院, 助教授 (20183741)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2003: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 2002: ¥11,000,000 (Direct Cost: ¥11,000,000)
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| Keywords | Asymmetry / NMDA receptor / Hippocampus / GluRε2 / mouse / synapse / 錐体細胞 / CA1 / シナプス / 左右差 / 長期増強現象 |
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| Research Abstract |
The hippocampus resides bilaterally in the telencephalon and has been considered as a symmetrical structure in the brain. Here we report that, synaptic distribution of NMDA receptor GluRε2 subunits in the adult mouse hippocampus is asymmetrical between the left and right, and between the apical and basal dendrites of single neurons. These asymmetrical allocations of GluRε2 subunits differentiate the properties of NMDA receptors and synaptic plasticity between the left and right hippocampus. The present result provides, for the first time, a molecular basis for the structural and functional asymmetry of the mature brain.
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Report
(3 results)
Research Products
(3 results)
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[Publications] Kawakami, R., Shinohara, Y., Kato, Y., Sugiyama, H., Shigemoto, R., Ito, I.: "Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry"Science. 300. 990-994 (2003)
Description
「研究成果報告書概要(和文)」より
Related Report
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[Publications] Kawakami, R., Shinohara, Y., Kato, Y., Sugiyama, H., Shigemoto, R., Ito, I: "Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry"Science. 300. 990-994 (2003)
Description
「研究成果報告書概要(欧文)」より
Related Report
-
[Publications] Kawakami, R., Shinohara, Y., Kato, Y., Sugiyama, H., Shigemoto, R., Ito.I.: "Asymmetrical allocation of NMDA receptor □2 subunits in hippocampal circuitry"Science. 300(5621). 990-994 (2003)
