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Basic Researches on the Micropositioning techniques of Cells and Biomaterials for Tissue Engineering

Research Project

Project/Area Number 14380393
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo Medical and Dental University, Institute of Biomaterials and Bioengineering

Principal Investigator

NAKAMURA Makoto  Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Associate Professor, 生体材料工学研究所, 助教授 (90301803)

Co-Investigator(Kenkyū-buntansha) TAKATANI Setsuo  Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Professor, 生体材料工学研究所, 教授 (40154786)
OHUCHI Katsuhiro  Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Assistant Professor, 生体材料工学研究所, 助手 (20322084)
IWASAKI Yasuhiko  Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Associate Professor, 生体材料工学研究所, 助教授 (90280990)
MORITA Ikuo  Tokyo Medical and Dental University, Graduate school, Professor, 大学院・医歯学総合研究科, 教授 (60100129)
HORIE Mikio  Tokyo Institute of Technology, Precision and Intelligence Laboratory, Professor, 精密工学研究所, 教授 (00126327)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥17,300,000 (Direct Cost: ¥17,300,000)
Fiscal Year 2004: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥14,500,000 (Direct Cost: ¥14,500,000)
KeywordsTissue Engineering / Organs for transplantation / Engineered vascular tissues / Biomaterials / inkjet / Bio-artificial organs / Micro manipulator / Bioprinting / Pantograph / Micro manipulator / Pantograph mechanism
Research Abstract

Biological tissues and organs are constructed with a microscopic structure, with several types of cells and extra cellular matrixes, in three dimensionally. Therefore, it is very important in the field of tissue engineering to establish the technologies to position living cells and biological materials precisely onto an intentionally targeted position.
In this research project, we have been aiming to make basic researches and to produce some innovative technologies to position living cells onto the targeted position, to contribute to develop tissue engineering. As some of the promising approaches, we have investigated the feasibility of micropositioning techniques of living cells and biomaterials such as using inkjet printing and micromanipulation techniques. And we summarized the concept and discussed about the possibilities of these approaches for tissue engineering.
We focused mainly on the inkjet techniques for tissue engineering. We have challenged to eject living cells using inkjet … More machine, and have investigated the damages of the ejected cells. As a result, we have recognized that we could eject living cells without significant damages. To avoid drying of cells and to construct three-dimensional structures, we developed a gel formation technique by inkjet printing. With this technique, we could prevent cells from drying and succeeded in the construction of three dimensional gel structures such as a lattice and a tube with fine gel fibers, including living cells in them. Such techniques for micropositioning of cells and biomaterials enables us to manufacture biological tissues with the techniques of computer aided designing and manufacturing. Innovative tissue engineering will come true.
Then, we designed a microvasculature pattern and evaluated it using the technique of computational fluid dynamics. In addition, we constructed computational three-dimensional model of organs from a clinical CT scan data, and made some three dimensional cast models based on such CAD data using three-dimensional printer.
In these ways, we have made basic researches on the micropositioning techniques of cells and biomaterials for tissue engineering and have demonstrated the possibility of these approaches using computer and micropositioning techniogies. Collaboration of advanced computer and mechanical technologies with tissue engineering will surely contribute to the future of tissue engineering medicine. Less

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (54 results)

All 2005 2004 2003 Other

All Journal Article (47 results) Patent(Industrial Property Rights) (1 results) Publications (6 results)

  • [Journal Article] Biocompatible Inkjet Printing Technique For Designed Seeding Of Individual Living Cells.2005

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      TISSUE ENGINEERING 11(11/12)

      Pages: 1658-1666

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] コンピュータと機械の力で心臓を創り出す2005

    • Author(s)
      中村真人, 他
    • Journal Title

      第33回人工心臓と補助循環懇話会抄録集

      Pages: 30-30

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Computer Aided Tissue Engineeringによる未来医療 : Computer Aided TIssue Designingの試み.2005

    • Author(s)
      中村真人, 他
    • Journal Title

      再生医療 3(suppl.)

      Pages: 183-183

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] インクジェット式Direct Tissue Engineering2005

    • Author(s)
      中村真人, 他
    • Journal Title

      再生医療 3(suppl.)

      Pages: 126-126

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 生細胞PrintingによるDirect Tissue Engineering2005

    • Author(s)
      中村真人, 他
    • Journal Title

      炎症・再生 25

      Pages: 321-321

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Micro Gel Beads for Tissue Engineering.2005

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      Final Program and Abstract Book, The 8th Annual Meeting of Tissue Engineering Society International

      Pages: 231-231

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 感温性ジェルを用いた3次元培地構造体の作成2005

    • Author(s)
      石田 謙太郎, 他
    • Journal Title

      第52回応用物理学関係連合講演会予稿集

      Pages: 1461-1461

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Creation of the heart with computer and machines2005

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      Abstract of the 33rd. Annual Conference on Artificial Heart and Artificial Circulation

      Pages: 30-30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Future Medicine by Computer Aided Tissue Engineering.2005

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      Regenerative Medicine 3(suppl.)

      Pages: 183-183

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Inkjet Direct Tissue Engineering.2005

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      Regenerative Medicine 3(suppl.)

      Pages: 126-126

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Direct Tissue Engineering by live cell printing2005

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      Inflammation and Regeneration 25

      Pages: 321-321

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Micro Gel Beads for Tissue Engineering2005

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      Final Program and Abstract Book, The 8th Annual Meeting of Tissue Engineering Society International

      Pages: 231-231

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Fabrication of 3-chmensional culture medium structure by the use of temperature sensitive gel2005

    • Author(s)
      Ishida K, et al.
    • Journal Title

      The 52nd. Annual Meeting of Japanese Society of Applied Physics : Abstracts

      Pages: 1461-1461

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Biocompatible Inkjet Printing Technique For Designed Seeding Of In dividual Living Cells.2005

    • Author(s)
      Nakamura M, Kobayashi A, et al.
    • Journal Title

      Tissue Engineering (投稿中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Computer Aided Tissue Engineeringによる未来医療2005

    • Author(s)
      中村真人, 小林暁子, 他
    • Journal Title

      再生医療 4(suppl.)

      Pages: 183-183

    • Related Report
      2004 Annual Research Report
  • [Journal Article] インクジェット式Direct Tissue Engineering2005

    • Author(s)
      中村真人, 小林暁子, 他
    • Journal Title

      再生医療 4(suppl.)

      Pages: 126-126

    • Related Report
      2004 Annual Research Report
  • [Journal Article] インクジェット技術のTissue Engineeringへの応用2004

    • Author(s)
      中村真人
    • Journal Title

      BioIndustry 21(12)

      Pages: 68-76

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Computer-Aided-Tissue-Engineeringのためのバイオインクジェットプリンティング.2004

    • Author(s)
      中村真人, 他
    • Journal Title

      再生医療 3(suppl.)

      Pages: 164-164

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] インクジェットプリントによる細胞ミクロ播種法の研究-血管内皮細胞のバイアビリティ.2004

    • Author(s)
      渡辺昭彦, 他
    • Journal Title

      再生医療 3(suppl.)

      Pages: 105-105

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Computer Aided Tissue Engineering : インクジェットによる二次元生体組織プリンティング.2004

    • Author(s)
      中村真人, 他
    • Journal Title

      生体医工学 42(suppl.1)

      Pages: 245-245

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Computer-Aided 2 Dimensional Capillary Vasculature Designing and Engineering.2004

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      ASAIO J 50(2)

      Pages: 167-167

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Biocompatible Inkjet Head For Printing with Viable Cells2004

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      Abstract Bool of Joint meeting of the Tissue Engineering Society International and the European Tissue Engineering Society,

      Pages: 80-80

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] インクジェットによるTissue Engineering2004

    • Author(s)
      中村真人, 他
    • Journal Title

      人工臓器 33(2)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Application of Inkjet technology for Tissue Engineering2004

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      BioIndustry 21(12)

      Pages: 68-76

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Bio-inkjet printing for Computer-Aided-Tissue-Engineering2004

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      Regenerative Medicine 3(suppl.)

      Pages: 164-164

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Research on micro-cell seeding by inkjet-Viability of vascular endothelial cells.2004

    • Author(s)
      Watanabe A, et al.
    • Journal Title

      Regenerative Medicine 3(suppl.)

      Pages: 105-105

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Computer Aided Tissue Engineering2004

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      Transactions of the Japanese Society for medical and biological engineering 42(suppl.)

      Pages: 245-245

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Biocompatible Inkjet Head For Printing with Viable Cells2004

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      Abstract Book of Joint meeting of the Tissue Engineering Society International and the European Tissue Engineering Society

      Pages: 80-80

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tissue Engineering by inkjet technology2004

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      The Japanese Journal of Artificial Organs 33(2)

      Pages: 128-128

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Computer-Aided-Tissue-Engineeringのためのバイオインクジェットプリンティング2004

    • Author(s)
      中村真人, 森田育男, 他
    • Journal Title

      再生医療 3(suppl.)

      Pages: 164-164

    • Related Report
      2004 Annual Research Report
  • [Journal Article] インクジェットプリントによる細胞ミクロ播種法の研究-血管内皮細胞のバイアビリティ2004

    • Author(s)
      渡辺昭彦, 中村真人, 他
    • Journal Title

      再生医療 3(suppl.)

      Pages: 105-105

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Computer Aided Tissue Engineering:インクジェットによる二次元生体組織プリンティング2004

    • Author(s)
      中村真人, 渡辺昭彦, 他
    • Journal Title

      生体医工学 42(suppl.1)

      Pages: 245-245

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Computer-Aided 2 Dimensional Capillary Vasculature Designing and Engineering.2004

    • Author(s)
      Nakamura M, Kobayashi A, et al.
    • Journal Title

      ASAIO J 50(2)

      Pages: 167-167

    • Related Report
      2004 Annual Research Report
  • [Journal Article] インクジェットによるTissue Engineering2004

    • Author(s)
      中村真人, 小林暁子, 他
    • Journal Title

      人工臓器 33(2)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Inkjet technique for the formation of alginate hydrogel containing living cells.2004

    • Author(s)
      Nakamura M, Kobayashi A, et al.
    • Journal Title

      Abstract Booklet of Bioprinting and Biopatterning Workshop 2004

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Biocompatible Inkjet Head For Printing with Viable Cells.2004

    • Author(s)
      Nakamura M, Kobayashi A, et al.
    • Journal Title

      Abstract of Joint meeting of Tissue Engineering Society International and European Tissue Engineering Society 2004.

      Pages: 80-80

    • Related Report
      2004 Annual Research Report
  • [Journal Article] コンピュータと機械の力で心臓を創り出す2004

    • Author(s)
      中村真人, 片岡弘之, 他
    • Journal Title

      第33回人工心臓と補助循環懇話会 抄録集

      Pages: 30-30

    • Related Report
      2004 Annual Research Report
  • [Journal Article] インクジェットによる細胞マイクロ播種法の研究2003

    • Author(s)
      中村真人, 他
    • Journal Title

      人工臓器 32(2)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] マイクロ流体力学解析を利用した毛細血管の流路設計2003

    • Author(s)
      中村真人, 他
    • Journal Title

      人工臓器 32(2)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Micro Cell Seeding with Living Cells using a Bio-Compatible Inkjet Printing Technique2003

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      Conference Abstract CD-ROM : 6th.Annual international conference of Tissue Engineering Society International

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] インクジェットによる細胞ジェットプリンティング2003

    • Author(s)
      中村真人, 他
    • Journal Title

      第25回日本バイオマテリアル学会大会予行集

      Pages: 221-221

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 大変形ヒンジとリンクからなる2自由度パンタグラフ機構の静・動特性2003

    • Author(s)
      石井祐樹, 他
    • Journal Title

      日本機械学会 機素潤滑設計部門 第3回機素潤滑設計部門講演会 講演論文集 No.03-03

      Pages: 129-132

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Research on micro-cell seeding by inkjet technology2003

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      The Japanese Journal of Artificial Organs 32(2)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Designing of the Capillary Vasculature using micro-CFD2003

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      The Japanese Journal of Artificial Organs 32(2)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Micro Cell Seeding with Living Cells using a Bio-Compatible Inkjet Printing Technique2003

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      Conference Abstract CD-ROM : 6th. Annual international conference of Tissue Engineering Society International

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cell jet printing by inkjet technology2003

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      Abstracts of the 25th. Annual Meeting of the Japanese Society for Biomaterials

      Pages: 221-221

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Static and dynamic characteristics of the pantograph mechanism with 2 degrees of freedom composed of super-elastic hinges and links2003

    • Author(s)
      Ishii Y, et al.
    • Journal Title

      3rd.Meeting of JSME Machine Design & Tribology Division of the Japan Society of Mechanical Engineers Abstracts No.03-03

      Pages: 129-132

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] インクジェット微粒子作製法と作製装置2005

    • Inventor(s)
      中村真人, 渡邉昭彦
    • Industrial Property Rights Holder
      東京医科歯科大学・神奈川科学技術アカデミー
    • Industrial Property Number
      2005-303367
    • Filing Date
      2005-10-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] 石井佑樹, 堀江三喜男, 中村真人, 他: "大変形ヒンジとリンクからなる2自由度パンタグラフ機構の静・動特性"日本機械学会 機素潤滑設計部門 第3回機素潤滑設計部門講演会講演論文集. No.03-03. 129-132 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 中村真人, 森田育男, 他: "インクジェットによる細胞マイクロ播種法の研究"人工臓器. 32(2). S-67 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 中村真人, 他: "マイクロ流体力学解析を利用した毛細血管の流路設計"人工臓器. 32(2). S-121 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakamura M, Morita I, et al.: "Micro Cell Seeding with Living Cells using a Bio-Compatible Inkjet Printing Technique."2003 Conference Abstracts ; 6th. Annual international conference and exposition of Tissue Engineering Society International. (CD-ROM). P088 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 中村真人, 森田育男, 他: "インクジェットによる細胞ジェットプリンティング"第25回日本バイオマテリアル学会大会 予稿集. 221 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 石井佑樹, トーマス・チュンメル, 堀江三喜男, 中村真人: "大変形ヒンジとリンクからなる2自由度パンタグラフ機構の静・動特性"日本機械学会 機素潤滑設計部門 第3回機素潤滑設計部門講演会講演論文集. (2003年4月に発表予定).

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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