• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a method of non-invasive measurement of wave intensity, a new hemodynamic index, and its clinical application.

Research Project

Project/Area Number 14380414
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo Women's Medical University

Principal Investigator

SUGAWARA Motoaki  Tokyo Women's Medical University, School of Medicine, Professor, 医学部, 教授 (60010914)

Co-Investigator(Kenkyū-buntansha) NIKI Kiyomi  Tokyo Women's Medical University, School of Medicine, Associate Professor, 医学部, 助教授 (40218095)
JOU Tokuka  Tokyo Women's Medical University, School of Medicine, Associate, 医学部, 助手 (10343550)
UJIIE Hiroshi  Tokyo Women's Medical University, School of Medicine, Associate Professor, 医学部, 助教授 (00138869)
原田 烈光  アロカ株式会社, 課長
岡田 孝  アロカ株式会社, 主任
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2002: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordsultrasound / wave intensity / cardiac function / elasticity / color Doppler / echo tracking / ウェーブ・インテンシティー / エコー・トラッキング / ウエーブ・インテンシティー / 超音波診断法 / 心血管系 / 頚動脈
Research Abstract

Wave intensity (WI) is a new index for evaluating ventriculo-arterial interactions. Wave intensity is defined as (dP/dt)(dU/dt) at any site of the circulation, where dP/dt and dU/dt are the time derivatives of blood pressure and velocity, respectively. Arterial wave intensity in normal subjects has two positive sharp peaks. The first peak occurs during early systole, the magnitude of which increases markedly with increases in cardiac contractility. The second peak, which occurs towards the end of ejection, decreases with increases in the time constant of left ventricular isovolumic relaxation. During mid-ejection between the two positive peaks of WI, negative peaks are often observed. The magnitude and the timing of these peaks give information about the strength of wave reflections and the distance between the measuring point and the position of the reflections. Although the potential usefulness of WI had been reported by several authors, there had been no on-line methods of measuring WI noninvasively. We developed an ultrasonic on-line system of measuring WI for the first time.
The system is composed of a computer, a WI unit and an Aloka ProSound SSD-6500 ultrasonic machine (Aloka, Tokyo) equipped with a combined tissue imaging (10 or 13 MHz) and Doppler (5 MHz) transducer. The WI unit receives RF echo signals and color Doppler signals from the ultrasonic machine, and calculates the change in diameter of the artery (M-mode echo tracking) and the mean blood velocity through the sampling gate (color M-mode Doppler). Since arterial pressure waveforms and diameter change waveforms are similar, a blood pressure waveform is obtained from a diameter change waveform by calibrating its peak and bottom values by systolic and diastolic blood pressure measured with a cuff-type manometer. We applied this method to the carotid artery in subjects with heart disease, and assessed ventriculo-arterial interactions quantitatively.

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (54 results)

All 2006 2005 2004 2003 2002 2001 Other

All Journal Article (33 results) Book (10 results) Patent(Industrial Property Rights) (2 results) Publications (9 results)

  • [Journal Article] スティッフネスパラメータβ.検査の実際と注意点2006

    • Author(s)
      仁木清美, 菅原基晃, 阿部一彦
    • Journal Title

      Medical Technology 34・1

      Pages: 35-40

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Stiffness parameter beta : practice in examination and instructions for use. (in Japanese)2006

    • Author(s)
      Kiyomi Niki, Motoaki Sugawara, Kazuhiko Abe.
    • Journal Title

      Medical Technology 34-1

      Pages: 35-40

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] スティッフネスパラメータβ.検査の実際と注意点2006

    • Author(s)
      仁木清美, 菅原基晃, 阿部一彦
    • Journal Title

      medical Technology 34・1

      Pages: 35-40

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effects of sublingual nitroglycerin on working conditions of the heart and arterial system- analysis using wave intensity.2005

    • Author(s)
      Niki Kiyomi, Sugawara Motoaki et al.
    • Journal Title

      J Med Ultrasonics 32・4

      Pages: 145-152

    • NAID

      10016915882

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 心臓と血管の干渉-Wave intensityによる評価.2005

    • Author(s)
      仁木清美, 菅原基晃
    • Journal Title

      映像情報 37・5

      Pages: 494-499

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 心臓と動脈系の干渉から見る動脈硬化 ウェーブインテンシティの応用.2005

    • Author(s)
      菅原基晃, 仁木清美, 常徳華
    • Journal Title

      INNER VISION 20・6

      Pages: 106-112

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 動脈硬化における血管の硬さとは?2005

    • Author(s)
      菅原基晃, 仁木清美, 常徳華
    • Journal Title

      Heart View 9・9

      Pages: 88-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] エコー法による動脈硬化の評価2005

    • Author(s)
      菅原基晃, 仁木清美, 常徳華
    • Journal Title

      心エコー 6・10

      Pages: 958-965

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of sublingual nitroglycerin on working conditions of the heart and arterial system- analysis using wave intensity.2005

    • Author(s)
      Kiyomi Niki, Motoaki Sugawara, Dehua Chang et al.
    • Journal Title

      J Med Ultrasonics 32-4

      Pages: 145-152

    • NAID

      10016915882

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ventriculo-arterial interaction : evaluation using wave intensity. (in Japanese)2005

    • Author(s)
      Kiyomi Niki, Motoaki Sugawara.
    • Journal Title

      Visual Information 37-5

      Pages: 494-499

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Arteriosclerosis assessed in the light of ventriculo-arterial interaction : application of wave intensity. (in Japanese)2005

    • Author(s)
      Motoaki Sugawara, Kiyomi Niki, Dehua Chang.
    • Journal Title

      Innervision 20-6

      Pages: 106-112

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] What is the stiffness of an artery in arteriosclerosis? (in Japanese)2005

    • Author(s)
      Motoaki Sugawara, Kiyomi Niki, Dehua Chang.
    • Journal Title

      Heart View 9-9

      Pages: 88-95

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Assessment of arteriosclerosis by echo. (in Japanese)2005

    • Author(s)
      Motoaki Sugawara, Kiyomi Niki, Dehua Chang.
    • Journal Title

      Cardiac Echo 6-10

      Pages: 958-965

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of sublingual nitroglycerin on working conditions of the heart and arterial system-analysis using wave intensity.2005

    • Author(s)
      Niki Kiyomi, Sugawara Motoaki
    • Journal Title

      J Med Ultrasonics 32・4

      Pages: 145-152

    • NAID

      10016915882

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 心臓と血管の干渉-Wave intensityによる評価.2005

    • Author(s)
      仁木清美, 菅原基晃
    • Journal Title

      映像情報 37・

      Pages: 494-499

    • Related Report
      2005 Annual Research Report
  • [Journal Article] エコー法における動脈硬化の評価2005

    • Author(s)
      菅原基晃, 仁木清美, 常徳華
    • Journal Title

      心エコー 6・10

      Pages: 958-965

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 血行動態からみた血圧2004

    • Author(s)
      細田瑳一, 菅原基晃
    • Journal Title

      Therapeutic Research 25(12)

      Pages: 2397-2428

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Clinical usefulness of carotid arterial wave intensity in assessing left ventricular systolic and diastolic performance.2003

    • Author(s)
      Ohte Nobuyuki, Sugawara Motoaki(3番目), Niki Kiyomi(4番目)他5名
    • Journal Title

      Heart Vessels 18

      Pages: 107-111

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] New methods of one-point measurement of pulse wave velocity.2003

    • Author(s)
      Harada Akimitsu, Okada Takashi, Niki Kiyomi, Chang Dehua, Sugawara Motoaki
    • Journal Title

      2002 IEEE International Ultrasonics Symposium Proceedings

      Pages: 1791-1794

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] エコーでみる血流速度と脈波伝播.2003

    • Author(s)
      仁木清美, 菅原基晃
    • Journal Title

      心エコー 4

      Pages: 1032-1037

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 局所脈波速度の非侵襲的1点測定.2003

    • Author(s)
      菅原基晃, 仁木清美, 常徳華, 岡田孝, 原田烈光
    • Journal Title

      最新医学 58

      Pages: 1521-1530

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Wave intensityをどう役立てるか?2003

    • Author(s)
      菅原基晃, 仁木清美, 岡田孝
    • Journal Title

      心エコー 4・10

      Pages: 894-902

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Clinical usefulness of carotid arterial wave intensity in assessing left ventricular systolic and diastolic performance.2003

    • Author(s)
      Nobuyuki Ohte, Motoaki Sugawara (3^<rd> author), Kiyomi Niki (4^<th> author) et al.
    • Journal Title

      Heart Vessels 18

      Pages: 107-111

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] New methods of one-point measurement of pulse wave velocity.2003

    • Author(s)
      Akimitsu Harada, Takashi Okada, Kiyomi Niki, Dehua Chang, Motoaki Sugawara.
    • Journal Title

      2002 IEEE International Ultrasonics Symposium Proceedings

      Pages: 1791-1794

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Blood flow velocity and pulse wave propagation in the light of ultrasonic echo. (in Japanese)2003

    • Author(s)
      Kiyomi Niki, Motoaki Sugawara.
    • Journal Title

      Cardiac Echo 4

      Pages: 1032-1037

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Non-invasive one-point measurement of local pulse wave velocity. (in Japanese)2003

    • Author(s)
      Motoaki Sugawara, Kiyomi Niki, Dehua Chang, Takashi Okada, Akimitsu Harada.
    • Journal Title

      Latest Medicine 58

      Pages: 1521-1530

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] How to make good use of wave intensity. (in Japanese)2003

    • Author(s)
      Motoaki Sugawara, Kiyomi Niki, Takashi Okada.
    • Journal Title

      Cardiac Echo 4-10

      Pages: 894-902

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A new noninvasive measurement system for wave intensity : evaluation of carotid arterial wave intensity and reproducibility.2002

    • Author(s)
      Niki Kiyomi, Sugawara Motoaki, Chang Dehua
    • Journal Title

      Heart Vessels 17

      Pages: 12-21

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] On-line noninvasive one-point measurements of pulse wave velocity.2002

    • Author(s)
      Harada Akimitsu, Okada Takashi, Niki Kiyomi, Chang Dehua, Sugawara Motoaki
    • Journal Title

      Heart Vessels 17

      Pages: 61-68

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Compression and expansion wavefront travel in canine ascending aortic flow : wave intensity analysis.2002

    • Author(s)
      Christopher J.H.Jones, Motoaki Sugawara(2番目), 他3名
    • Journal Title

      Heart Vessels 16

      Pages: 91-98

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A new noninvasive measurement system for wave intensity : evaluation of carotid arterial wave intensity and reproducibility.2002

    • Author(s)
      Kiyomi Niki, Motoaki Sugawara, Dehua Chang.
    • Journal Title

      Heart Vessels 17

      Pages: 12-21

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] On-line noninvasive one-point measurements of pulse wave velocity.2002

    • Author(s)
      Akimitsu Harada, Takashi Okada, Kiyomi Niki, Dehua Chang, Motoaki Sugawara.
    • Journal Title

      Heart Vessels 17

      Pages: 61-68

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Compression and expansion wavefront travel in canine ascending aortic flow : wave intensity analysis.2002

    • Author(s)
      Christopher J.H.Jones, Motoaki Sugawara et al.
    • Journal Title

      Heart Vessels 16

      Pages: 91-98

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 血管エコー,11章動脈硬化 : wave intensity(松尾 汎 編)2006

    • Author(s)
      菅原基晃, 仁木清美, 常徳華
    • Total Pages
      187
    • Publisher
      インナービジョン
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 血管エコーABC,III各論-頚動脈 Augmentation index(松尾 汎 編)2006

    • Author(s)
      菅原基晃, 仁木清美, 常徳華
    • Total Pages
      221
    • Publisher
      メジカルビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Arteriosclerosis : wave intensity. In : Vessel Echo (Hiroshi Matsuo (ed).)2006

    • Author(s)
      Motoaki Sugawara, Kiyomi Niki, Dehua Chang.
    • Publisher
      Innervision Publisher (in Japanese)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Carotid artery : augmentation index. In : Vessel Echo ABC (Hiroshi Matsuo (ed).)2006

    • Author(s)
      Motoaki Sugawara, Kiyomi Niki, Dehua Chang.
    • Publisher
      Medical View Publisher (in Japanese)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] すべてわかる血管エコーABC : III各論-頚動脈 Augmentation index2005

    • Author(s)
      菅原基晃, 仁木清美, 常徳華
    • Total Pages
      221
    • Publisher
      メジカルビュー社
    • Related Report
      2005 Annual Research Report
  • [Book] 超音波医学最前線,26章ウェーブインテンシティの超音波計測(伊東紘一 編)2004

    • Author(s)
      菅原基晃, 仁木清美
    • Total Pages
      231
    • Publisher
      医歯出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Ultrasonic measuremwnts of wave intensity. In : Frontiers of Ultrasonic Medicine (Kouichi Ito (ed).)2004

    • Author(s)
      Motoaki Sugawara, Kiyomi Niki.
    • Publisher
      Ishiyaku Publisher (in Japanese)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 26ウェーヴインテンシティの超音波計測 超音波医学 最前線-新技術と臨床応用(伊東紘一編)2004

    • Author(s)
      菅原基晃, 仁木清美
    • Total Pages
      231
    • Publisher
      医師薬出版
    • Related Report
      2004 Annual Research Report
  • [Book] 血液のレオロジーと血流.2003

    • Author(s)
      菅原基晃, 前田信冶
    • Total Pages
      139
    • Publisher
      コロナ社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Blood Rheoloav and Blood Flow.2003

    • Author(s)
      Motoaki Sugawara, Nobuji Maeda.
    • Publisher
      Corona Publisher (in Japanese)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 脈波伝播速度計測装置及び超音波診断装置2001

    • Inventor(s)
      原田烈光, 岡田 孝, 菅原基晃
    • Industrial Property Rights Holder
      アロカ株式会社, 菅原基晃
    • Filing Date
      2001-01-30
    • Acquisition Date
      2005-04-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 脈波伝播速度計装置及び超音波診断装置2001

    • Inventor(s)
      原田 烈光, 岡田 孝, 菅原 基晃
    • Industrial Property Rights Holder
      アロカ株式会社, 菅原 基晃
    • Filing Date
      2001-01-30
    • Acquisition Date
      2005-04-15
    • Related Report
      2005 Annual Research Report
  • [Publications] Akimitsu Harada: "New methods of one-point measurement of pulse wave velocity"2002 IEEE International Ultrasonics Symposium Proceedings. 1791-1794 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nobuyuki Ohte: "Clinical usefulness of carotid arterial wave intensity in assessing left ventricular systolic and diastolic performance"Heart and Vessels. 18. 107-111 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 菅原基晃: "Wave intensityをどう役立てるか?"心エコー. 4. 894-902 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 菅原基晃: "局所脈波速度の非侵襲的1点測定"最新医学. 58. 1521-1530 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 仁木清美: "エコーでみる血流速度と脈波伝搬"心エコー. 4. 1032-1037 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 菅原基晃: "血液のレオロジーと血流"コロナ社. 139 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Niki K, Sugawara M, Chang D, Harada A, Okada T, Sakai R, et al.: "A new noninvasive measurement system for wave intensity : evaluation of carotid arterial wave intensity and reproducibility"Heart Vessels. 17. 12-21 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Harada A, Okada T, Niki K, Chang D, Sugawara M.: "On-line noninvasive one-point measurements of pulse wave velocity"Heart Vessels. 17. 61-68 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 菅原基晃: "伊東紘一, 平田經雄編 血管・血流超音波医学"医歯薬出版、東京. 23-30 (2002)

    • Related Report
      2002 Annual Research Report

URL: 

Published: 2002-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi