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Development of intrauterine endoscopic surgical tools at early stage during pregnancy

Research Project

Project/Area Number 14390007
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 広領域
Research InstitutionTohoku University

Principal Investigator

HAGA Yoichi  Tohoku University, Biomedical Engineering Research Organization, Associate Professor, 先進医工学研究機構, 助教授 (00282096)

Co-Investigator(Kenkyū-buntansha) ESASHI Masayoshi  Tohoku University, Graduate School of Engineering, Professor, 大学院・工学研究科, 教授 (20108468)
CHIBA Tashio  National Center for Child Health and Development, Chief Physician, 特殊診療部, 医長
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 2004: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2003: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2002: ¥7,800,000 (Direct Cost: ¥7,800,000)
Keywordsintrauterine surgery / embryo / minimally invasive surgery / laser treatment / ultrasound / マイクロスキャナー
Research Abstract

Surgery of fetus and embryo is being shifted from open fetal surgery to fetoscopic procedure. In this research, several endoscopic surgical tools have been developed for intrauterine endoscopic surgery at early stage during pregnancy, for example, ultrasonic endoscope for observation of fetus and embryo, micro laser scanning tool and focused ultrasonic probe as treatment tools.
For precise laser treatment in uterus, a 2D (two dimensional) laser scanning micro tool has been developed. The tool is made up of an optical fiber, a micro rod lens and a 2D microscanner. The 2D microscanner has three piezoelectric unimorph cantilevers. The mirror is supported by a pivot from underside and is inclined by pushing down by three cantilevers on the top of the mirror. Scanning of 100-um-diameter spot of KTP laser was confirmed. For insertion the tool into a working channel of a conventional endoscope, these components are packaged into a 3.8-mm-external-diameter polymer tube. As ultrasonic tools, convex-shaped 8 ring array ultrasonic imager of 3-mm-diameter and concave-shaped ultrasonic transducer for ultrasonic treatment have been developed. Each transducer of the imager can detect echo signal from an aluminum board in water. Imaging of tissue in the fetus / embryo will be tested. A 6-mm-diameter ultrasonic treatment tool has been fabricated and power generation of ultrasound at intensity for treatment was confirmed.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (22 results)

All 2005 2004 2003 Other

All Journal Article (15 results) Patent(Industrial Property Rights) (2 results) Publications (5 results)

  • [Journal Article] 低侵襲医療のための光MEMS2005

    • Author(s)
      芳賀洋一
    • Journal Title

      レーザー研究 33(2005年11月掲載予定)

    • NAID

      10016855412

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tube Shape Piezoelectric 2D Microscanner for Minimally Invasive Laser Treatment2005

    • Author(s)
      H.Akahori
    • Journal Title

      Technical Digest of the 18th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2005)

      Pages: 76-79

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Optical MEMS for Minimally Invasive Therapy2005

    • Author(s)
      Yoichi Haga
    • Journal Title

      The Rev of Laser Engineering Vol.33(in press, Nov.2005)

    • NAID

      10016855412

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tube Shape Piezoelectric 2D Microscanner for Minimally Invasive Laser Treatment2005

    • Author(s)
      H.Akahori
    • Journal Title

      MEMS 2005

      Pages: 76-79

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tube Shape Piezoelectric 2D Microscanner for Minimally Invasive Laser Treatment2005

    • Author(s)
      H.Akahori
    • Journal Title

      Technical digest of the 18th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2005)

      Pages: 76-79

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Development of Medical Devices for Minimally Invasive Diagnosis and Therapy Using Micro/nano Technology2005

    • Author(s)
      Y.Haga
    • Journal Title

      Biosensors & Biomaterials Workshop 2005 (Biosensors 2005),Tsukuba, Japan (2005,March,7-9)

      Pages: 0-29

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 体内レーザー治療のための圧電駆動2次元マイクロスキャナーの開発2005

    • Author(s)
      赤堀 寛昌
    • Journal Title

      第44回日本生体医工学会大会(日本エム・イー学会)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Piezoelectric 2D Microscanner for Precise Laser Treatment in the Human Body2005

    • Author(s)
      H.Akahori
    • Journal Title

      3rd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine & Biology, Hawaii, USA (2005,May 12-15)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] マイクロ・ナノマシニング技術を用いた低侵襲検査・治療機器2004

    • Author(s)
      芳賀洋一
    • Journal Title

      日本AEM学会誌 12

      Pages: 106-111

    • NAID

      110003829021

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Fabrication of Low Directional Acoustic Transducers for Intravascular Forward-looking Imaging2004

    • Author(s)
      J.J.Chen
    • Journal Title

      Technical Digest of the 17th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2004)

      Pages: 857-860

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Medical Devices for Minimally Invasive Diagnosis and Treatment Using Micro-nano machining2004

    • Author(s)
      Yoichi Haga
    • Journal Title

      Journal of JSAEM Vol.12

      Pages: 106-111

    • NAID

      110003829021

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Fabrication of Low Directional Acoustic Transducers for Intravascular Forward-looking Imaging2004

    • Author(s)
      J.J.Chen
    • Journal Title

      MEMS 2004

      Pages: 857-860

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Piezoelectric 2D microscanner for intracorporeal laser treatment2004

    • Author(s)
      H.Akahori
    • Journal Title

      Asia-Pacific Conference of Transducers and Micro-Nano Technology (APCOT MNT 2004)

      Pages: 211-214

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Piezoelectric 2D Micro Scanner for Minimally Invasive Therapy Fabricated Using Femtosecond Laser Ablation2003

    • Author(s)
      N.Kikuchi
    • Journal Title

      Digest of Technical Papers of The 12th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers'03)

      Pages: 603-606

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Piezoelectric 2D Micro Scanner for Minimally Invasive Therapy Fabricated Using Femtosecond Laser Ablation2003

    • Author(s)
      N.Kikuchi
    • Journal Title

      Transducers'03

      Pages: 603-606

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] Scanning Mirror Unit and Beam Scanning Probe2004

    • Inventor(s)
      N.Kikuchi, M.Esashi, Y.Haga, M.Maeda
    • Industrial Property Rights Holder
      PENTAX corporation, M.Esashi, Y.Haga
    • Filing Date
      2004-06-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 走査ミラー、ビーム走査型プローブ2003

    • Inventor(s)
      江刺 正喜, 芳賀 洋一, 前圧 真法, 菊地 直樹
    • Industrial Property Rights Holder
      ペンタックス株式会社, 江刺 正喜, 芳賀 洋
    • Industrial Property Number
      2003-163449
    • Filing Date
      2003-06-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] N.Kikuchi, Y.Haga, M.Maeda, W.Makishi, M.Esashi: "Piezoelectric 2D Micro Scanner for Minimally Invasive Therapy Fabricated Using Femtosecond Laser Ablation"Digest of Technical Papers of The 12th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers '03). 603-606 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 赤堀 寛昌, 芳賀 洋一, 菊池 直樹, 江刺 正喜, 和田 仁: "体腔内治療用2次元マイクロスキャナーの開発"日本機械学会 第14回バイオフロンティア講演会講演論文集. 117-118 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 赤堀 寛昌, 芳賀 洋一, 江刺 正喜, 和田 仁: "圧電駆動マイクロ2次元スキャナーを用いた体腔内レーザー治療用デバイスの開発"日本機械学界 第16回バイオエンジニアリング講演会講演論文集. 115-116 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] H.Akahori, Y.Haga, K.Totsum, M.Esashi, H.Wada: "Piezoelectric 2D microscanner for intracorporeal laser treatment"Asia-Pacific Conference of Transducers and Micro-Nano Technology (APCOT MNT 2004). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Maeda, Y.Haga, N.Kikuchi, W.Makishi, M.Esashi: "Piezoelectric 2D Micro Scanner for Minimally Invasive Therapy Fabricated Using Femtosecond Laser Ablation"Tech.Dig.12th Int.Conf.Solid-State Sensors and Actuators (Transducers'03). (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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