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Molecular Pathological Analysis of Digestive Cancers around Semipalatinsk Nuclear Testing Site

Research Project

Project/Area Number 14406002
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Experimental pathology
Research InstitutionNagasaki University

Principal Investigator

SEKINE Ichiro  Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (60039922)

Co-Investigator(Kenkyū-buntansha) YAMASHITA Shunichi  Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (30200679)
SHIBATA Yoshisada  Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (40010954)
OTSURU Akira  Nagasaki University, Hospital of Medicine and Dentistry, Associate Professor, 医学部・歯学部附属病院, 助教授 (00233198)
TAKAMURA Noboru  Nagasaki University, Graduate School of Biomedical Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 (30295068)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2002: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsSemipalatinsk / Stomach cancer / p53 / p21 / EB virus / セミパラチンクス核実験場 / セミパラチンスク / 放射線誘発癌 / 遺伝子バンク
Research Abstract

Since 1949,hundreds of nuclear tests had been conducted at Semipalatinsk Nuclear Testing Site(SNTS) in Kazakhstan, during the period of former USSR. Due to the secret system of former USSR, clarification of health effect in the population residing around SNTS is quite difficult. It is estimated that irradiated population around SNTS during the periods of nuclear testing has a certain risk of late effects of radiation exposure, especially malignancy. However it is quite difficult to clarify the real situation, due to the insufficient medical and epidemiological infrastructure in this area.
On the other hand, molecular mechanism of radiation induced cancer has been extensively investigated in order to clarify the late effect of radiation in A-bomb survivors in Nagasaki and Hiroshima. It was reported that the incidence of stomach cancer was increased after 30 years of A-bomb. However, its mechanism has not been clarified. Based on these backgrounds, we promoted the molecular pathological joint research on the evaluation of stomach cancer around SNTS, in cooperation with the Department of Pathology of Semipalatinsk Medical Academy. Furthermore, we screened the expression of EBV-encoded small RNA-1(EBER-1) by in situ hybridization, in order to evaluate the incidence of virus-induced stomach cancer in this area, and showed that the positive EBER-1 was observed in 10.8% of Russian and 8.9% of Asian population. These results suggest that the incidence of stomach cancer caused by EBV infection is not a significant confounding variable for the evaluation of radiation induced cancer, since the ratio of EVB infection of this cohort is not significantly different between Western countries and Japan. In future, we plan to develop the molecular pathological studies targeted p53 and p21, in addition to the introduction of new technologies, such as Comparative Genomic Hybridization(CGH).

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (60 results)

All 2005 2004 2003 2002 Other

All Journal Article (43 results) Book (5 results) Publications (12 results)

  • [Journal Article] Overexpression of Ets-1 proto-oncogene in latent and clinical prostatic carcinomas.2005

    • Author(s)
      Alipov G 他
    • Journal Title

      Histopathology 46・2

      Pages: 202-208

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Epstein-Barr virus-associated gastric carcinoma in Kazakhstan.2005

    • Author(s)
      Alipov G 他
    • Journal Title

      World J Gastroenterol 11・1

      Pages: 27-30

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Loss of heterozygosity on chromosome 9q22.3 in microdissected basal cell carcinomas around the Semipalatinsk Nuclear Testing Site, Kazakhstan.2004

    • Author(s)
      Iwata K 他
    • Journal Title

      Human Pathology 35・4

      Pages: 460-464

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cyclin D1 overexpression in thyroid tumours from a radio-contaminate area and its correlation with pin1 and aberrant beta-catenin expression.2004

    • Author(s)
      Nakashima M 他
    • Journal Title

      Journal of Pathology 202・4

      Pages: 446-455

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of Tie-1 and 2 receptors, and angiopoietin-1,2 and 4 in gastric carcinoma ; immunohistochemical analyses and correlation with clinicopathological factors.2004

    • Author(s)
      Nakayama T 他
    • Journal Title

      Histopathology 44・3

      Pages: 232-239

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Low frequency of BRAFT1796A mutations in childhood thyroid carcinomas.2004

    • Author(s)
      Kumagai A 他
    • Journal Title

      J Clin Endocrinol Metab 89・9

      Pages: 4280-4284

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Thyroid blockade during a radiation emergency in iodine-rich areas : effect of a stable-iodine dosage.2004

    • Author(s)
      Takamura N 他
    • Journal Title

      J Radiat Res 45・2

      Pages: 201-204

    • NAID

      110004041017

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Comparison of Ximelagatran with Warfarin for the Prevention of Venous Thromboembolism after Total Knee Replacement.2004

    • Author(s)
      Nishiguchi M 他
    • Journal Title

      N Engl J Med 350

      Pages: 616-617

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Loss of heterozygosity on chromosome 9q22.3 in microdissected basal cell carcinomas around the Semipalatinsk Nuclear Testing Site, Kazakhstan.2004

    • Author(s)
      Iwata K et al.
    • Journal Title

      Human Pathology 35(4)

      Pages: 460-464

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cyclin D1 overexpression in thyroid tumours froma radio-contaminate Area and its correlation with Pinl and aberrant beta-catenin expression.2004

    • Author(s)
      Nakashima M et al.
    • Journal Title

      Journal of Pathology 202(4)

      Pages: 446-455

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of Tie-1 and 2 receptors, and angiopoietin-1,2 and 4 in gastric carcinoma ; immunohistochemical analyses and correlation with clinicopathological factors2004

    • Author(s)
      Nakayama T et al.
    • Journal Title

      Histopathology 44(3)

      Pages: 232-239

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Low frequency of BRAFT1796A mutations in childhood thyroid carcinomas.2004

    • Author(s)
      Kumagai A et al.
    • Journal Title

      J Clin Endocrinol Metab 89(9)

      Pages: 4280-4284

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Thyroid blockade during a radiation emergency in iodine-rich areas : effect of a stable-iodine dosage.2004

    • Author(s)
      Takamura N et al.
    • Journal Title

      J Radiat Res 45(2)

      Pages: 201-204

    • NAID

      110004041017

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparison of Ximelagatran with Warfarin for the Prevention of Venous Thromboembolism after Total Knee Replacement.2004

    • Author(s)
      Nishiguchi M et al.
    • Journal Title

      N Engl J Med 350

      Pages: 616-617

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cyclin D1 overexpression in thyroid tumours from a radio-contaminated area and its correlation with Pin1 and aberrant beta-catenin expression.2004

    • Author(s)
      Nakashima M 他
    • Journal Title

      J Pathol 202・4

      Pages: 446-455

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Loss of heterozygosity on chromosome 9q22.3 microdissected basal cell carcinomas around the Semipalatinsk Nuclear Testing Site, Kazakhstan.2004

    • Author(s)
      Iwata K 他
    • Journal Title

      Hum Pathol 35・4

      Pages: 460-464

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Low frequency of BRAFT1796A mutations in thyroid carcinomas.2004

    • Author(s)
      Kumagai A 他
    • Journal Title

      J Clin Endocrinol Metab 89・9

      Pages: 4280-4284

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression of Parathyroid Hormone(PTH)-related Peptide(PTHrP) and PTH/PTHrP Receptor in Osteoclast-like Giant Cells.2003

    • Author(s)
      Nakashima M 他
    • Journal Title

      Pathol Res Pract 199

      Pages: 85-92

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Small Cell Carcinoma of the Endometrium : Report of a Case with Analysis of Wnt/β-Catenin Pathway.2003

    • Author(s)
      Meirmanov S 他
    • Journal Title

      Pathol Res Pract 199

      Pages: 551-558

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Correlation of cytoplasmic beta-catenin and cyclin D1 overexpression during thyroid carcinogenesis around Semipalatinsk nuclear test site.2003

    • Author(s)
      Meirmanov S 他
    • Journal Title

      Thyroid 13

      Pages: 537-545

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] No evidence of radiation risk for thyroid gland among schoolchildren around semipalatinsk nuclear testing site.2003

    • Author(s)
      Hamada A 他
    • Journal Title

      Endocr J 50

      Pages: 85-89

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Benign thyroid diseases among Chernobyl liquidators.2003

    • Author(s)
      Zagurovskaya M 他
    • Journal Title

      Endocr J 50・6

      Pages: 837-838

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Iodine prophylaxis around the Semipalatinsk Nuclear Testing Site, Republic of Kazakstan.2003

    • Author(s)
      Hamada A 他
    • Journal Title

      Public Health Nutr 6

      Pages: 785-789

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of Parathyroid Hormone(PTH)-related Peptide(PTHrP) and PTH/PTHrP Receptor in Osteoclast-like Giant Cells.2003

    • Author(s)
      Nakashima M et al.
    • Journal Title

      Pathol Res Pract 199

      Pages: 85-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Small Cell Carcinoma of the Endometrium : Report of a Case with Analysis of Wnt/β-Catenin Pathway.2003

    • Author(s)
      Meirmanov S et al.
    • Journal Title

      Pathol Res Pract 199

      Pages: 551-558

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Correlation of cytoplasmic beta-catenin and cyclin D1 overexpression during thyroid carcinogensis around Semipalatinsk nuclear test site.2003

    • Author(s)
      Meirmanov S et al.
    • Journal Title

      Thyroid 13

      Pages: 537-545

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] No evidence of radiation risk for thyroid gland among schoolchildren around Semipalatinsk nuclear testing site.2003

    • Author(s)
      Hamada A et al.
    • Journal Title

      Endocr J 50

      Pages: 85-89

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Benign thyroid diseases among Chernobyl liquidators.2003

    • Author(s)
      Zagurovskaya M et al.
    • Journal Title

      Endocr J 50(6)

      Pages: 837-838

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Iodine prophylaxis around the Semipalatinsk Nuclear Testing Site, Republic of Kazakhstan.2003

    • Author(s)
      Hamada A et al.
    • Journal Title

      Public Health Nutr 6

      Pages: 785-789

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanism of the antiulcerogenic effect of IL-11 on acetic acid-induced gastric ulcer in rats.2002

    • Author(s)
      Wen CY 他
    • Journal Title

      Life Sci 70

      Pages: 2997-3005

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Preventive effects of parathyroid hormone-related peptide on gastric hypercontraction in the rat.2002

    • Author(s)
      Ito M 他
    • Journal Title

      J Gastroenterol Hepatol 17

      Pages: 1260-1266

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Altered expression of beta-catenin during radiation-induced colonic carcinogenesis.2002

    • Author(s)
      Nakashima M 他
    • Journal Title

      Pathol Res Pract 198

      Pages: 717-724

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Large deletions in mitochondrial DNA in radiation associated human thyrid tumors.2002

    • Author(s)
      Rogounovitch I T 他
    • Journal Title

      Cancer Res 62・23

      Pages: 7031-7041

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of receptor tyrosine kinase axl and its ligand gas6 in pediatric thyroid carcinomas around Chernobyl.2002

    • Author(s)
      Ito M 他
    • Journal Title

      Thyroid 12・11

      Pages: 969-973

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Aberrant localization of beta-Catenin correlates with overexpression of its target gene in human papillary thyroid cancer.2002

    • Author(s)
      Ishigaki K 他
    • Journal Title

      J Clin Endocrinol Metab 87・7

      Pages: 3433-3440

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of Receptor Tyrosine Kinase Axl and its Ligand Gas6 in Pediatric Thyroid Carcinomas around Chernobyl.2002

    • Author(s)
      Ito M 他
    • Journal Title

      Thyroid 12・11

      Pages: 971-975

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanism of the antiulcerogenic effect of IL-11 on acetic acid-induced gastric ulcer in rats.2002

    • Author(s)
      Wen CY et al.
    • Journal Title

      Life Sci 70

      Pages: 2997-3005

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Preventive effects of parathyroid hormone-related peptide on gastric hypercontraction in the rat.2002

    • Author(s)
      Ito M et al.
    • Journal Title

      J Gastroenterol Hepatol 17

      Pages: 1260-1266

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Altered expression of beta-catenin during radiation-induced colonic carcinogenesis.2002

    • Author(s)
      Nakashima M et al.
    • Journal Title

      Pathol Res Pract 198

      Pages: 717-724

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Large deletions in mitochondrial DNA in radiation associated human thyrid tumors.2002

    • Author(s)
      Rogounovitch I T et al.
    • Journal Title

      Cancer Res 62(23)

      Pages: 7031-7041

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of receptor tyrosine kinase axl and its ligand gas6 in pediatric thyroid carcinomas around Chernobyl.2002

    • Author(s)
      Ito M et al.
    • Journal Title

      Thyroid 12(11)

      Pages: 969-973

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Aberrant localization of beta-Catenin correlates with overexpression of its target gene in human papillary thyroid cancer2002

    • Author(s)
      Ishigaki K et al.
    • Journal Title

      J Clin Endocrinol Metab 87(7)

      Pages: 3433-3440

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of Receptor Tyrosine Kinase Axl and its Ligand Gas6 in Pediatric Thyroid Carcinomas around Chernobyl.2002

    • Author(s)
      Ito M et al.
    • Journal Title

      Thyroid 12(11)

      Pages: 971-975

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 病理学概論第2版2003

    • Author(s)
      関根 一郎
    • Publisher
      医歯薬出版株式会社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Radiation and Humankind2003

    • Author(s)
      Shibata Y 他
    • Total Pages
      308
    • Publisher
      Elsevier
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] International Congress Series 27732003

    • Author(s)
      Yamashita S
    • Publisher
      Elsevier
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] The Genetics of Complex Thyroid Diseases2002

    • Author(s)
      Yamashita S 他
    • Publisher
      Springer-Verlag Tokyo
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Radiation and Homeostasis2002

    • Author(s)
      Yamashita S 他
    • Publisher
      Elsevier
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Iwata K, Takamura N, Sekine I他: "Loss of heterozygosity on chromosome 9q22.3 in microdissected basal cell carcinoma around Semipalatinsk nuclear testing site, Kazakhstan"Human Pathology. 印刷中.

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakashima M, Meirmanov S, Sekine他: "Altered expression of beta-catenin during radiation-induced colonic carcinogenesis"Pathol Res Pract. 199. 85-92 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Namba H, Yamashita S他: "Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers"J Clin Endocrinol Metab. 88・9. 4393-4397 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hamada A, Takamura N他: "No evidence of radiation risk for thyroid gland among schoolchildren around Semipalatinsk nuclear testing site"Endocrine J. 50・4. 85-59 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Meirmanov S, Yamashita S, Sekine I他: "Correlation of Cytoplasmic β-Catenin and Cyclin D1 Overexpression During Thyroid Carcinogenesis Around Semipalatinsk Nuclear Test Site"Thyroid. 13・6. 537-545 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nishiguchi M, Takamura N他: "Comparison of Ximelagatran with Warfarin for the Prevention of Venous Thromboembolism after Total Knee Replacement"N Engl J Med. 350・6. 616-617 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Wen CY, Nakashima M, Nakayama T, Sekine I et al.: "Overexpression of Heat Shock Protein 70 in the Stomach of Stress-Induced Gastric Ulcer-Resistant Spontaneously Hypertensive Rats"Clin Exp Hypertension. 24・6. 448-449 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shichijo K, Ihara M, Sekine I et al.: "Overexpression of Heat Shock Protein 70 in the Stomach of Stress-Induced Gastric Ulcer-Resistant Spontaneously Hypertensive Rats"Clin Exp Hypertension. 24・6. 448-449 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ito M, Nakashima M, Nakayama, Ohtsuru A, Sekine I et al.: "Preventive effects of parathyroid hormone-related peptide on gastric hypercontraction in the rat"Gastroenterol Hepatol. 17・12. 1260-1266 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tsuda S, Ohtsuru A, Yamashita S et al.: "Role of c-Fyn in FGF-2-mediated tube-like structure formation by murine brain capillary endothelial cells"Biochem Biophys Res Commun. 290・4. 1354-1360 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Akiyama-Uchida Y, Ashizawa N, Yamashita S et al.: "Norepinephirine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts"Hypertension. 40・2. 148-154 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ito M, Nakashima M, Sekine I et al.: "Expression of receptor-type tyrosine kinase, axl its ligand, gas6, in pediatric thyroid carcinomas around chernobyl"Thyroid. 12・11. 971-975 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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