| Project/Area Number |
14406004
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
寄生虫学(含医用動物学)
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
TOMA Hiromu University of the Ryukyus, Faculty of Medicine, Associate Professor, 医学部, 助教授 (80231447)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Hisami University of the Ryukyus, COMB, Professor, 遺伝子実験センター, 教授 (50143756)
ARAKAWA Takeshi University of the Ryukyus, COMB, Associate Professor, 遺伝子実験センター, 助教授 (50305190)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥9,300,000 (Direct Cost: ¥9,300,000)
Fiscal Year 2004: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2003: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥3,400,000 (Direct Cost: ¥3,400,000)
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| Keywords | malaria infection / Laos / cross sectional survey / drug sensitivity test / Plasmodium falciparum / autoantibody production / anti-nuclear antibodies |
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| Research Abstract |
In order to find out the exact information on control measure for malaria infection, we conducted in 10 villages of the southern provinces, Saravane and Attapeu, by cross sectional surveys and drug sensitivity test for Plasmodium falciparum infection. The surveys were performed from February 2003 to September 2004. A total of 2779 inhabitants were examined and malaria infection was confirmed in 8.0% of the inhabitants. In vivo and in vitro drug sensitivity tests were performed to P.falciparum isolates from patients using ; chloroquine, Fansidar, and mefloquine. Chloroquine, Fansidar-resistant parasites were confirmed in some degree, but all isolates were sensitive for mefloquine. It is supposed that multi-drug resistant malaria has not yet distributed in the southern area of Laos.
On the other hand, we studied whether the autoantibody production in falciparum malaria patients had played the protective or pathogenic role. Our results showed that there was no difference between malaria patients and control subjects for the serum levels of IgG- or IgM-type ANA(anti-nuclear antibodies). As mentioned above, we propose the additional studies for relationships among the ANA levels, disease severity, cytokine production and lymphocyte subsets in falciparum malaria patients.
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