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The research for the ethnical differences of the susceptibility genes of rheumatic diseases in East Asia.

Research Project

Project/Area Number 14406018
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field 内科学一般
Research InstitutionThe University of Tokyo

Principal Investigator

TAKEUCHI Fujio  Tokyo University, Tokyo Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (70154979)

Co-Investigator(Kenkyū-buntansha) SAWADA Tetsuji  Tokyo University, Tokyo Faculty of Medicine, Assistant professor, 医学部付属病院, 助手 (50235470)
HARIHARA Shinji  Tokyo University, Department of Biological Sciences Graduate School of science, Assistant professor, 大学院・理学系研究科, 助手 (40198932)
SAKUTA Hiroshi  Aoyama Gakuen University, Department of Mechanical Engineering, Professor, 理工学部, 教授 (10170630)
KUWATA Shoji  Teikyo University, Teikyo University School of Medicine Ichihara Hospital, Assistant professor, 医学部付属市原病院, 助教授 (00241993)
石川 雄一  癌研究会, 癌研究所, 主任研究員 (80222975)
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 2004: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2003: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2002: ¥6,200,000 (Direct Cost: ¥6,200,000)
Keywordsrheumatoid arthritis / scleroderma / Behcet Disease / Werner syndrome / genetic factor / East Asia / ethnical difference / rheumatic disease / SSC / 台湾 / 韓国 / 遺伝子
Research Abstract

The purpose of this research is to clarify the genetic background of the rheumatic diseases based on the common or different genetic factor, and to collect the samples. The followings are agreements with oversea collaborators in Korea, Taiwan and Thai. 1.RA, SSc, Behcet disease (BD), Werner syndrome (WS) are first target diseases. 2.The target genes and auto-antibodies including CARF were recognized. 3.The common clinical chart was approved. 4.The consensus were approved on the samples and the analytical-results. 5.Each country is responsible for Informed Consent of the country. 6.In this research the Data-Base-form (ASCA) was developed on the network-system. 7.Samples have been collected in all countries. In Japan the collection of samples from control, RA and BD have gone satisfactorily. 8.The analyses of HLA-DR, HLA-B and CTLA-4 were almost completed in control and have been gone in RA and BD. We have found no association between RA and CTLA-4. 9.The TNF^*2 increased significantly in RA with DRB1^*0405 independently. TNFa11 and b4 increased slightly accompanied with the *0405. The basic trials were done on EST-1, GPIIIa, MBP and TLR4. For several genetic factors including TAP, the comparisons with data from foreign countries have been done. 10.Using the model-data, the EH program was verified and the problems have been shown. The analytical system of common-use has been developed. 11.The collaborations with Korea have been done by exchange informations of analyses and data of the target genes. The collaborations with Taiwan and Thai have been done on analyses of HLA, CTLA-4, TNF, CARF, et al. We are going to forward the new research project from 2005, that is the renewal project of this research, based on the research-bases have been constructed by this project.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (80 results)

All 2006 2005 2004 2003 2002 Other

All Journal Article (62 results) Book (6 results) Publications (12 results)

  • [Journal Article] The genetic contribution of the CTLA-4 dimorphisms in promoter and exon l regions in Japanese RA.2006

    • Author(s)
      Takeuchi F, et al.
    • Journal Title

      Scan J Rheumatol. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The genetic contribution of the CTLA-4 dimorphisms in promoter and exon 1 regions in Japanese RA.2006

    • Author(s)
      Takeuchi F, et al.
    • Journal Title

      Scan J Rheumatol. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genetic contribution of the tumor necrosis factor (TNF)B+252*2/2 genotype,but not the TNFa,b microsatellite alleles, to systemic lupus erythematosus in Japnese patients.2005

    • Author(s)
      Takeuchi F, et al.
    • Journal Title

      Int. J Immunogenetics 32

      Pages: 173-178

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The genetic contribution of the TNFall microsatellite allele and the TNF+252*2 allele in Japanese RA.2005

    • Author(s)
      Takeuchi F, et al.
    • Journal Title

      Clin Exp Rheumatol 23

      Pages: 494-498

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Epstein-Barr virus infection in childhood may precipitate atopic diseases.2005

    • Author(s)
      Okudaira R, et al.
    • Journal Title

      Allergology International 54

      Pages: 483-490

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The CTLA-4-1661A/G & -1772T/C dimorphism in Japanese patients with systemic lupus erthematosus.2005

    • Author(s)
      Takeuchi F, et al.
    • Journal Title

      J Rheumatol 32

      Pages: 2062-2063

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association of TAP1 and TAP2 gene polymorphisms with systemic sclerosis in Korean patients.2005

    • Author(s)
      Song YW, et al.
    • Journal Title

      Hum Immunol, 66

      Pages: 810-817

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 免疫学的検査-HLA抗原血清学的検査法.2005

    • Author(s)
      桑田 昇治
    • Journal Title

      日本臨床 63増刊

      Pages: 738-744

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 免疫学的検査-HLA リンパ球混合培養法(MLC).2005

    • Author(s)
      桑田 昇治
    • Journal Title

      日本臨床 63増刊

      Pages: 745-749

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 免疫学的検査-HLA-DNAタイピング.2005

    • Author(s)
      桑田 昇治
    • Journal Title

      日本臨床 63増刊

      Pages: 750-756

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 免疫学的検査-HLAキメリズム解析.2005

    • Author(s)
      桑田 昇治
    • Journal Title

      日本臨床 63増刊

      Pages: 757-760

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genetic contribution of the tumor necrosis factor (TNF) B+252^*2/2 genotype, but not the TNFa, b microsatellite alleles, to systemic lupus erythematosus in Japanese patients.2005

    • Author(s)
      Takeuchi F., et al.
    • Journal Title

      Int. J Immunogenetics 32

      Pages: 173-178

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The genetic contribution of the TNFa11 microsatellite allele and the TNF+252^*2 allele in Japanese RA.2005

    • Author(s)
      Takeuchi F., et al.
    • Journal Title

      Clin Exp Rheumatol 23

      Pages: 494-498

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Epstein-Barr virus infection in childhood may precipitate atopic diseases.2005

    • Author(s)
      Okudaira R., et al.
    • Journal Title

      Allergology International 54

      Pages: 483-490

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The CTLA-4-1661A/G & 1772T/C dimorphism in Japanese patients with systemic lupus erythematosus.2005

    • Author(s)
      Takeuchi F., et al.
    • Journal Title

      J Rheumatol 32

      Pages: 2062-2063

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association of TAP1 and TAP2 gene polymorphisms with systemic sclerosis in Korean patients.2005

    • Author(s)
      Song YW., et al.
    • Journal Title

      Hum Immunol 66

      Pages: 810-817

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Immunological examination serological typing of HLA.2005

    • Author(s)
      Kuwata S
    • Journal Title

      Nipponrinsho 63(supple)

      Pages: 738-744

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Immunological examination HLA, mixed lymphocyte culture method (MLC)2005

    • Author(s)
      Kuwata S
    • Journal Title

      Nipponrinsho 63(supple)

      Pages: 745-749

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Immunological examination HLA-DNA typing.2005

    • Author(s)
      Kuwata S
    • Journal Title

      Nipponrinsho 63(supple)

      Pages: 750-756

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Immunological examination -HLA chimera analysis2005

    • Author(s)
      Kuwata S
    • Journal Title

      Nipponrinsho 63(supple)

      Pages: 757-760

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genetic contribution of the tumor necrosis factor (TNF)B+252^*2/2 genotype, but not the TNFa, b microsatellite alleles, to systemic lupus erythematosus in Japanese patients2005

    • Author(s)
      Takeuchi F., et al.
    • Journal Title

      Eur J Immunogenetics 32(in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The genetic contribution of the TNFall microsatellite allele and the TNFB+252^*2 allele in Japanese RA2005

    • Author(s)
      Takeuchi F., et al.
    • Journal Title

      Clin Exp Rheumatol 23(in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Re-evaluation of the β-globin gene cluster haplotypers in Japnese, Koreans, and three Colombian Amerinds(Wayuu,Kamsa, and Inga tribes).2004

    • Author(s)
      Shimizu K, et al.
    • Journal Title

      Anthropological Science. 112

      Pages: 109-114

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Allele frequency of inosinetriphosphate pyrophosphatase gene polymorphisms in a japanese population.2004

    • Author(s)
      Marinaki AM, et al.
    • Journal Title

      Nucleosides Nucleotides Nucleic Acids 23

      Pages: 1399-1401

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Characteristic bata-globin gene cluster haplotypes of Evenkis and Oroqens in north China.2004

    • Author(s)
      Shimizu k, et al.
    • Journal Title

      Hum Biol 76

      Pages: 765-778

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 発掘された人体試料についての遺伝子分析.2004

    • Author(s)
      針原 伸二, 他
    • Journal Title

      史紋 2

      Pages: 5-18

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 中国漢民族5集団におけるY染色体 Binary Polymorphism の分布.2004

    • Author(s)
      湯浅 勲, 他
    • Journal Title

      DNA多型 12

      Pages: 252-256

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 江戸時代の人の脳試料を用いたDNA解析.2004

    • Author(s)
      鶴井 郁子, 他
    • Journal Title

      DNA多型 12

      Pages: 288-292

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Webサービスによる東郷エンジニアリング環境の構築2004

    • Author(s)
      佐久田 博司, 他
    • Journal Title

      日本機械学会設計工学・システム部門講演会講演論文 14

      Pages: 166-167

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Re-evaluation of the β-globin gene cluster haplotypes in Japanese, Koreans, and three Colombian Amerinds (Wayuu, Kamsa, and Inga tribes).2004

    • Author(s)
      Shimizu K, et al.
    • Journal Title

      Anthropological Science 112

      Pages: 109-114

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Allele frequency of inosinetriphosphate pyrophosphatase gene polymorphisms in a Japanese population.2004

    • Author(s)
      Marinaki AM, et al.
    • Journal Title

      Nucleosides Nucleotides Nucleic Acids. 23

      Pages: 1399-1401

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Characteristic beta-globin gene cluster haplotypes of Evenkis and Oroqens in north China.2004

    • Author(s)
      Shimizu K, et al.
    • Journal Title

      Hum Biol 76

      Pages: 765-778

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The genetic analyses of the excavated samples of human (in Japanese)2004

    • Author(s)
      Harihara S, et al.
    • Journal Title

      Shimonn 2

      Pages: 5-18

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The distribution of the binary polymorphism on Y chromosome in 5 Chinese populations. (in Japanese)2004

    • Author(s)
      Yuasa I, et al.
    • Journal Title

      DNA polymorphism 12

      Pages: 252-256

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The DNA analyses of the brain samples in the Edo era. (in Japanese)2004

    • Author(s)
      Tsurui I, et al.
    • Journal Title

      DNA polymorphism 12

      Pages: 288-292

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The constitution of the systemic engineering condition by the Web service. (in Japanese)2004

    • Author(s)
      Sakuta H, et al.
    • Journal Title

      Nihonn Kikai Gakkai Sekkei Kougaku, Shisutemu Bumonn Kouennkai Kouenn Ronnbunn 14

      Pages: 166-167

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Crystal induced arthritis. (in Japanese)2004

    • Author(s)
      Takeuchi F
    • Journal Title

      In Practical Medical Manual for Rheumatic and Collagen Diseases (edited by Goto M, Bunkodo)

      Pages: 267-279

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The mitochondrial DNA A3243G mutation in Werner's syndrome.2003

    • Author(s)
      Takeuchi F, et al.
    • Journal Title

      Exp Gerontol. 38

      Pages: 339-342

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] CTLA-4 dimorphisms in Japanese patients with sysmic lupus erythematosus.2003

    • Author(s)
      Takeuchi F, et al.
    • Journal Title

      Clin Exp Rheum 21

      Pages: 527-528

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association of transporter associated with antigen processing genes with Behcet'sDisease in Japnese.2003

    • Author(s)
      Takizawa K, et al.
    • Journal Title

      Autoimmunity 36

      Pages: 161-165

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Single nucleotide polymorphisms in the human complement C6 and C' genes.2003

    • Author(s)
      Nishimukai H, et al.
    • Journal Title

      Legal Medicine 5(Suppll)

      Pages: 198-200

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The mitochondorial DNA A3243G mutation in Werner's syndrome.2003

    • Author(s)
      Takeuchi F., et al.
    • Journal Title

      Exp Gerontol 38

      Pages: 339-342

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] CTLA-4 dimorphisms in Japanese patients with systemic lupus erythematosus.2003

    • Author(s)
      Takeuchi F., et al.
    • Journal Title

      Clin Exp Rheum 21

      Pages: 527-528

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association of transporter associated with antigen processing genes with Behcet's Disease in Japanese.2003

    • Author(s)
      Takizawa K., et al.
    • Journal Title

      Autoimmunity 36

      Pages: 161-165

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Single nucleotide polymorphisms in the human complement C6 and C7 genes.2003

    • Author(s)
      Nishimukai H, et al.
    • Journal Title

      Legal Medicine 5 Suppl1

      Pages: 198-200

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Section Editor of the section of physical therapy. (in Japanese)2003

    • Author(s)
      Takeuchi F, et al.
    • Journal Title

      In Medical Dictionary (edited by Ito M et al.)(Igakushoin, Tokyo)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Immunogenetics. (in Japanese)2003

    • Author(s)
      Kuwata S
    • Journal Title

      In Internal Medicine 2^<nd> ed., (edited by Kurokawa et al.)(Bunkodo)

      Pages: 24-30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Object-Oriented Numerical Method in JAVA. (in Japanese)2003

    • Author(s)
      Kobayashi F, et al.
    • Journal Title

      In Object-Oriented Numerical Method in JAVA (edited by Kobayashi F, et al.)(Koronasha)

      Pages: 117-160

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] e-learning Practical Method. (in Japanese)2003

    • Author(s)
      Tamaki T, et al.
    • Journal Title

      In e-learning Practical Method, (edited by Tamaki T, et al.)(Omusha)

      Pages: 196-198

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mode of inheritance of HLA-DRB1 shared epitope in Japanese familial rheumatoid srthritis.2002

    • Author(s)
      Takeuchi F, et al.
    • Journal Title

      Clin Exp Rheum 20

      Pages: 395-398

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparison of the level of mitochondrial DNA A3243G mutation in esophageal epithelium and myocerdium from individuals of very advanced age.2002

    • Author(s)
      Harihara S, et al.
    • Journal Title

      Exp Gerontol 37

      Pages: 917-923

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association of CTLA-4 with systemic sclerosis in Japanses patients.2002

    • Author(s)
      Takeuchi F, et al.
    • Journal Title

      Clin Exp Rteum 20

      Pages: 823-828

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Structural analysis of IgG oligosaccharides of patients with Sjogren'ssyndrome.2002

    • Author(s)
      Kuroda Y, et al.
    • Journal Title

      Glycoconjugate J. 19

      Pages: 23-31

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Apolopoprotein E and H polymorphisms in Mongolian Buryat : Allele frequencies and relationship with plasma lipid levels.2002

    • Author(s)
      Tunoda K, et al.
    • Journal Title

      Human Biology 74

      Pages: 659-671

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Wear of Plastic Spur Gears made by Injection Molding.2002

    • Author(s)
      Bushimata T, et al.
    • Journal Title

      Japanese Journal of Tribology 46

      Pages: 889-889

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mode of inheritance of HLA-DRB1 shared epitope in Japanese familial rheumatoid arthritis.2002

    • Author(s)
      Takeuchi F., et al.
    • Journal Title

      Clin Exp Rheum 20

      Pages: 395-398

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparison of the level of mitochondrial DNA A3243G mutation in esophageal epithelium and myocardium from individuals of very advanced age.2002

    • Author(s)
      Harihara S., et al.
    • Journal Title

      Exp Gerontol 37

      Pages: 917-923

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association of CTLA-4 with systemic sclerosis in Japanese patients.2002

    • Author(s)
      Takeuchi F., et al.
    • Journal Title

      Clin Exp Rheum 20

      Pages: 823-828

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Structural analysis of IgG oligosaccharides of patients with Sjogren's syndrome.2002

    • Author(s)
      Kuroda Y., Takeuchi F., et al.
    • Journal Title

      Glycoconjugate J 19

      Pages: 23-31

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Apolipoprotein E and H polymorphisms in Mongolian Buryat : Allele frequencies and relationship with plasma lipid levels2002

    • Author(s)
      Tsunoda K, et al.
    • Journal Title

      Human Biology 74

      Pages: 659-671

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Wear of Plastic Spur Gear made by Injection Molding.2002

    • Author(s)
      Bushimata T, et al.
    • Journal Title

      Journal of Tribology 46

      Pages: 889-889

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] HLA. (in Japanese)2002

    • Author(s)
      Kuwata S
    • Journal Title

      In The laboratory data of patients treated by dialysis (edited by Kurokawa et al.)(Nippon Medical Center)

      Pages: 316-321

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 結晶誘発性関節炎.(リウマチ・膠原病診療実践マニュアル 第2版)(後藤眞編)2004

    • Author(s)
      竹内 二士夫
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 物理療法.(医学大事典)(伊藤正男, 井村裕夫, 高久史麿総編集)2003

    • Author(s)
      竹内 二士夫
    • Publisher
      医学書院(編集)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 免疫遺伝学.(内科学第2版)(黒川清, 松澤佑次 編)2003

    • Author(s)
      桑田 昇治
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Javaによるオブジェクト指向数値計算法,2003

    • Author(s)
      小林 史典, 他
    • Publisher
      コロナ社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] eラニング実践法・サイバーアライアンスの世界.2003

    • Author(s)
      玉木 欽也, 他
    • Publisher
      オーム社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] HLA(透析患者の検査値の読み方)(黒川清 監修)2002

    • Author(s)
      桑田 昇治
    • Publisher
      日本メディカルセンター
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Takeuchi F., et al.: "The mitochondrial DNA A3243G mutation in Werner's syndrome."Exp Gerontol. 38. 339-342 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takeuchi F., et al.: "CTLA-4 dimorphisms in Japanese patients with systemic lupus erythematosus."Clin Exp Rheum. 21. 527-528 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 奥平博一 他: "アレルギー疾患はなぜ増加する?-Possible role of EBV in the pathogenes is of atopic disease-."喘息. 16. 2-8 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 粕谷大智 他: "関節リウマチに対する鍼治療-RA活動性とQOL(Quality of life)を指標に-."臨床リウマチ. 15. 277-281 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 川杉要 他: "PRPP合成酵素."日本臨床. 61. 20-23 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 竹内二士夫:物理療法(編集): "医学大辞典(伊藤正男、井村裕夫、高久史麿総編集)"医学書院(印刷中). (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takeuchi F et al.: "Mode of inheritance of HLA-DRBI shared epitope in Japanese familial rheumatoid arthritis"Clin Exp Rheum. 20. 395-398 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takeuchi F et al.: "Association of CTLA-4 with systemic sclerosis in Japanese patients"Clin Exp Rheum. 20. 823-828 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Harihara S et al.: "Comparison of the level of mitochondrial DNA A3243G mutation in esophageal epithelium and myocardium from individuals of very advanced age"Exp Gerontol. 37. 917-923 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tsunoda K et al.: "Apolipoprotein E and H palymorphisms in Mongolian Buryat : allele frequencies and relationship with plasma lipid levels"Hum Biol. 74. 659-671 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 川杉 要他: "PRPP合成酵素活性亢進症"日本臨床. 61. 284-287 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 川杉 要他: "PRPP合成酵素欠損症"日本臨床. 61. 383-385 (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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