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Mechanisms of trhombocytopenia in dengue virus infections

Research Project

Project/Area Number 14406019
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field 内科学一般
Research InstitutionNagasaki University

Principal Investigator

OISHI Kazunori  Nagasaki University, Institute of Tropical Medicine, Associate Professor, 熱帯医学研究所, 助教授 (80160414)

Co-Investigator(Kenkyū-buntansha) MORITA Kouichi  Nagasaki University, Institute of Tropical Medicine, Professor, 熱帯医学研究所, 教授 (40182240)
HASEBE Futoshi  Nagasaki University, Institute of Tropical Medicine, Lecturer, 熱帯医学研究所, 講師 (20253693)
KUMATORI Atsushi  Nagasaki University, Institute of Tropical Medicine, Lecturer, 熱帯医学研究所, 講師 (60244092)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥8,900,000 (Direct Cost: ¥8,900,000)
Fiscal Year 2003: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥5,300,000 (Direct Cost: ¥5,300,000)
Keywordsdengue virus / secondary infection / thrombocytopenia / PAIgG / PAIgM / severity of disease / デング二次感染 / PAIgG / PAIgM / 血管透過性亢進 / VEGF / トロンボポチン
Research Abstract

Severe thrombocytopenia and increased vascular permeability are two major characteristics of dengue hemorrhagic fever (DHF). To develop a better understanding of the roles of platelet-associated IgG (PAIgG) and IgM (PAIgM) in inducing thrombocytopenia and its severity of disease in patients with secondary dengue virus infection, the relationship between the PAIgG or PAIgM levels and disease severity as well as thrombocytopenia was examined in 78 patients with acute phase of secondary infection in a prospective hospital-based study. The decrease in platelet count during the acute phase significantly creased during the convalescent phase. In contrast, the increased levels of PAIgG or PAIgM that occured during the acute phase of these patients significantly decreased during the convalescent phase. An inverse correlation between platelet count and PAIgG or PAIgM levels was found in these patients. Anti-dengue virus IgG and IgM activity was found in platelet eluates from 10 patients in an acute phase of secondary infection. Increased levels of PAIgG or PAIgM were significantly higher in DHF than those in DF. An increased level of PAIgM was independently associated with the development of DHF, representing a possible predictor of DHF with a high specificity. Our present data suggest that platelet-associated immunoglobulins involving anti-dengue virus activity play an important role in the induction of thrombocytopenia and the severity of the disease in secondary dengue virus infections.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Oishi K, et al.: "Correlation between increased platelet-associated lgG and thrombocytopenia in secondary dengue virus infections."J Med Virol. 71. 259-264 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Oishi K, et al.: "Association of dengue virus-specific lgG on platelets is specific for the acute phase in an imported Japanese patient with secondary dengue 2 virus infection."Jap J Trop Med Hyg. 31. 223-225 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Cinco MTDD, Oishi K, Morita K, et al.: "The clinical serological, and virological aspects of dengue fever/demgue hemorrhagic fever in a private tertiary care hospital in Manila, Pilippines."St.Luke's J of Med. 1. 9-12 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takahashi H, Oishi K, et al.: "Decreased serum opsonic activity against Streptococcus pneumoniae in human immunodeficiency virus-infected Ugandan adults."Clin Infect Dis. 37. 1534-1540 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masaki H, Oishi K, et al.: "A clinical, serological and immunological study In a Japanese traveler with dengue fever."J Infect Chemother. 8. 365-367 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Oishi K, Inoue S, Cinco MT, Dimaano EM, Alera MT, Alfon JA, Abanes F, Cruz DJ, Matias RR, Matsuura H, Hasebe F, Tanimura S, K matori A, Morita K, Natividad FF, Nagatake T: "Correlation between increased platelet-associated IgG and thrombocytopenia in secondary dengue virus infections."J Med Virol.. 71. 259-264 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Oishi K, Inoue S, Kuramoto T, Onizuka S, Saito M, Hasebe F, Morita K, Nagatake T.: "Association of dengue virus-specific IgG on platelets is specific for the acute phase in an imported Japanese patient with secondary dengue 2 virus infection."Jap J Trop Med Hyg. 31. 223-225 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Cinco MTDD, Carlos CC, Oishi K, Inoue S, Matias RR, Cruz DJ, Hasebe F, Morita K, Natividad FF, Aguila FS, Igarashi A, Nagatake T: "The clinical, serological, and virological aspects of dengue fever/ demgue hemorrhagic fever in a private tertiary care hospital in Manila, Pilippines."St. Luke's J of Med.. 1. 9-12 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masaki H, Hasebe F, Ahmed K, Fukuda T, Furumoto A, Watanabe K, Oishi K, Igarashi A, Nagatake T.: "A clinical, serological and immunological study in a Japanese traveler with dengue fever."J Infect Chemother. 8. 365-367 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takahashi H, Oishi K, Yoshimine H, Kumatori A, Moji K, Watanabe K, Nalwoga H, Tugume SB, Kebba A, Mugerwa R, Mugyenyi P, Nagatake T: "Decreased serum opsonic activity against Streptococcus pneumoniae in human immunodeficiency virus-infected Ugandan adults."Clin Infect Dis.. 37. 1534-1540 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Amano H, Oishi K, et al.: "Essential contribution of monocyte chemoattractant protein-1/C-C chemokine ligand-2 to resolution and repair processes in acute bacterial pneumonia"J.Immunol.. 172. 398-409 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Watanabe H, Oishi k, et al.: "Possible high rate of transmission of nontypeable Haemophilus influenzae including β-lactamase-negative ampicillin-resistant strains between children and their parents"J Clin Microbiol. 42. 362-365 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Oishi K, et al.: "Association of dengue virus-specific IgG on platelets is specific for the acute phase in an imported Japanese patient with secondary dengue 2 virus infection"Jap J Trop Mcd Hyg. 31. 223-225 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Oishi K, et al.: "Correlation between increased platelet-associated IgG and thrombocytopenia in secondary dengue virus infections"J Med Virol. 71. 259-264 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Watanabe H, K, Oishi K, et al.: "Antimicrobial susceptibility and serotype distribution of Streptococcus pneumoniae and molecular characterization of multidrug-resistant serotype 19F, 6B, and 23F Pneumococci in northem Thailand"J Clin Microbiol. 41. 4178-4183 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takahashi H, Oishi K, et al.: "Decreased serum opsonic activity against Streptococcus pneumoniae in human immunodeficiency virus-infected Ugandan adults"Clin Infect Dis.. 37. 1534-1540 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 大石和徳他: "分子予防環境医学"本の泉社. 768 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tsuchihashi Y, Oishi K, et al.: "Fourteen-member macrolide suppress interleukin-8 production but not promote apoptosis of activated neutrophils. Antimicrob"Agents. Chemother.. 46. 1101-1104 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mitsushima H, Oishi K, et al.: "Acid aspiration induces bacterial pneumonia by enhanced bacterial adherence in mice"Microb Pathog. 33. 203-210 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nagatake T, Oishi K, et al.: "Prevention of respiratory infections by povidone-iodine gargle"Dermatology. 204(supp). 32-36 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masaki H, Oishi K, et al.: "A clinical, serological and immunological study in a Japanese traveler with dengue fever"J Infect Chemother. 8. 356-367 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamaryo T, Oishi K, et al.: "Fourteen-member macrolides promote the phospatidylserine receptor-dependent phagocytosis of apoptotic neutrophils by alveolar macrophages"Antimicrob. Agents. Chemother.. 47(1). 48-53 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Motomura K, Oishi K, et al.: "Different subtype distribution in two cities in Myanmar : evidence for independent cluster of HIV-transmission"AIDS.. 17. 633-636 (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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