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Exploration for Traditional Antimalarial Medicinal Plants in Central Africa

Research Project

Project/Area Number 14406029
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field 医薬分子機能学
Research InstitutionOsaka University

Principal Investigator

MURAKAMI Nobutoshi  Graduated School of Pharmaceutical Sciences, Osaka University, Prof., 薬学研究科, 教授 (00210013)

Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2003: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2002: ¥4,900,000 (Direct Cost: ¥4,900,000)
Keywordsmalaria / medicinal plants / central Africa / traditional antimalarials / flavonol monoglycoside / Democratic Republic of Congo / iridoid / flavonoid-C-glycoside / 中央アフリカ / コンゴ / 抗マラリア / 薬用植物 / 伝承薬 / フラボノイド配糖体 / 選択毒性 / 成分探索
Research Abstract

In this project, our group visited the Democratic Republic of Congo in order to search and collect medicinal plants used for malaria therapy traditionally. With the assistance of Dr. Kubata, a Professor of Kinshasa University and local healers who prescribe medicinal plants to local people we could collect 18 kinds of antimalarial medicinal plants. In the first instance, we evaluated for in vitro growth inhibitory activity on malaria parasites. As a result of our evaluation, 15 kinds of medicinal plants were shown to inhibit proliferation of Plasmodium falciparum potently. Next, We assessed in vivo antimalarial efficacy by use of P. berghei infected mice. In consequence, the three medicinal plants, Euphorbia hirta, Hymenocardia acida, Morinda morindoides, were revealed to exhibit attractive in vivo potency without showing any cytotoxicity. Furthermore, bioassay-guided separation of the MeOH extracts of the three plants resulted in the isolation of flavonol monoglycosides, flavonoid-C-glycosides, and phenyl propanoid conjugated iridoids as responsible active principles. It should be noteworthy that the three active principles are fairly different from known antimalarial drugs in terms of their chemical structures. In addition, all of the three active principles showed antimalarial activity against a drug resistance strain.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] N.Murakami et al.: "Synthesis of a Bioprobe for Elucidation of Target Molecule of Spongean Anti-malarial Peroxides."Bioorg.Med.Chem.Lett.. 14(in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Murakami et al.: "New Analogue of Arenastatin A, a Potent Cytotoxic Spongean Depsipeptide with Anti-tumor Activity."Bioorg.Med.Chem.Lett.. 14(10). 2597-2601 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Murakami et al.: "New Anti-malarial Peroxides with In Vivo Potency Derived from Spongean Metabolites."Bioorg.Med.Chem.Lett.. 13(22). 4081-4084 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Murakami et al.: "New Semi-synthetic Quassinoids with Leading in Vivo Anti-malarial Activity."J.Med.Chem.. 46(4). 638-641 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Murakami: "Exploration for new anti-malarial leads using ingredients from medicinal plants as scaffolds."Foods & Food Ingredients Journal of Japan. 209(1). 60-66 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Murakami et al.: "Synthesis of a Bioprobe for Elucidation of Target Molecule of spongean Antimalarial Peroxides."Bioorg.Med.Chem.Lett.. 14(in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Murakami et al.: "New Analogue of Arenastatin A, a Potent Cytotoxic Spongean Depsipeptide, with Anti-tumor Activity."Bioorg.Med.Chem.Lett.. 14(10). 2597-2601 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Murakami et al.: "New Anti-malarial Peroxides with In Vivo Potency Derived from Spongean Metabolites."Bioorg.Med.Chem.Lett.. 13(22). 4081-4084 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Murakami et al.: "New Semi-synthetic Quassinoids with Leading in Vivo Anti-malarial Activity."J.Med.Chem.. 46(4). 638-641 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Murakami: "Exploration for new anti-malarial leads using ingredients from medicinal plants as scaffolds."Foods & Food Ingredients Journal of Japan. 209(1). 60-66 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Murakami et al.: "Synthesis of a Bioprobe for Elucidation of Target Molecule of Spongean Anti-malarial Peroxides"Bioorg.Med.Chem.Lett.. 14(in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Murakami et al.: "New Analogue of Arenastatin A, a Potent Cytotoxic Spongean Depsipeptide, with Anti-tumor Activity"Bioorg.Med.Chem.Lett.. 14(in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Murakami et al.: "New Anti-malarial Peroxides with In Vivo Potency Derived from Spongean Metabolites"Bioorg.Med.Chem.Lett.. 13(22). 4081-4084 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Murakami et al.: "New Semi-synthetic Quassinoids with Leading in Vivo Anti-malarial Activity"J.Med.Chem.. 46(4). 638-641 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Murakami: "Exploration for new anti-malarial leads using ingredients from medicinal plants as scaffolds"Foods & Food Ingredients Journal of Japan. 209(1). 60-66 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Murakami et al.: "New Semi-synthetic Quassinoids with Leading in Vivo Anti-malarial Activity"J. Med. Chem. 46(4). 638-641 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] N.Murakami et al.: "Facilely Accessible Multidrug Resistance Modulator Derived from Sucrose"Bioorg. &Med. Chem. Lett.. 12(22). 2807-2810 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] N.Murakami et al.: "New Rev-Transport Inhibitor with Anti-HIV Activity from Valerianae Radix"Bioorg. &Med. Chem. Lett.. 12(20). 2807-2810 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] N.Murakami et al.: "Exploration for anti-cancer leads through synthetic approach utilizing biologically active natural products as seed principles"Natural Medicines. 56(3). 73-77 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] N.Murakami et al.: "New readily accessible peroxides with high anti-malarial potency"Bioorg. &Med. Chem. Lett.. 12(1). 69-72 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] N.Murakami et al.: "Facile construction of 3-methoxy-6-carbomethoxymethyl-1,2-dioxane, a core structure of spongean anti-malarial peroxides"Tetrahedron Lett.. 42(41). 7281-7285 (2001)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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