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Detection of parkinsonism causing substances in French West Indies

Research Project

Project/Area Number 14406032
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Neurochemistry/Neuropharmacology
Research InstitutionHIROSHIMA UNIVERSIlY

Principal Investigator

OHTA Shigeru  Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (60160503)

Co-Investigator(Kenkyū-buntansha) KUZUHARA Shigeki  Mie University, School of Medicine, Professor, 医学部, 教授 (70111383)
KOTAKE Yaichiro  Hiroshima University, Graduate School of Biomedical Sciences, Research Associate, 大学院・医歯薬学総合研究科, 助手 (20335649)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥12,800,000 (Direct Cost: ¥12,800,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2002: ¥10,800,000 (Direct Cost: ¥10,800,000)
KeywordsParkinson's disease / tetrahvdroisogunoline / Annonaceae family / SH-SY5Y cells / progressive supranuclear palsy / ノルレティキュリン / 国際情報交換 / フィリピン:フランス
Research Abstract

In Guadeloupe, the French West Indies, there is a high incidence of atypical parkinsonism or progressive supranuclear palsy, and all of the investigated patients had taken herbal tea or tropical fruits of the Annonaceae family. In the present study, we detected benzylisoquinoline derivatives in the Annonaceae family. These compounds were toxic to SH-SY5Y cells and inhibited mitochondrial respiratory complex I.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] K.Okuda, Y.Kotake, S.Ohta: "Determination method of 1-methyl-1,2,3,4-tetrahydroisoquinoline, an endogenous parkinsonism-preventing substance, by radioimmunoassay."Life Sci.. 70. 2871-2883 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] A.Storch, et al.: "Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease : studies using heterologous expression systems of the dopamine transporter."Biochem.Pharmacol.. 63. 909-920 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Kotake, et al.: "Neurotoxicity of an endogenous brain amine, 1-benzyl-1,2,3,4-tetrahydroisoquin line, in organotypic slice co-culture of mesencephalon and striatum."Neuroscience. 117. 63-70 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Okuda, Y.Kotake, S.Ohta.: "Neuroprotective or neurotoxic activity of 1-methyl 1,2,3,4-tetra-hydroisoquinoline and related compounds."Bioorg.Med.Chem.Lett.. 13. 2853-2855 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Kotake, S.Ohta: "MPP+ analogs acting on mitochondria and inducing neuro-degeneration."Current Medicinal Chemistry. 10. 2507-2516 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 太田 茂: "「パーキンソン病のすべて」パーキンソン病における神経毒"星和書店. 115-120 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Okuda et al.: "Determination method of 1-methyl-1,2,3,4-tetrahydro-isoquinoline, an endogenous parkinsonism-preventing substance, by radloimmunoassay"Life Sci.. 70. 2871-2883 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] A.Storch, et al.: "Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease : studies using heterologous expression systems of the dopamine transporter"Biochem. Pharmacol.. 63. 909-920 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Kotake, et al.: "Neurotoxicity of an endogenous brain amine, 1-benzyl-1,2,3,4-tetrahydroisoquinoline, in organotypic slice co-culture of mesencephalon and striatum"Neuroscience. 117. 63-70 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Okuda, et al.: "Neuroprotective or neurotoxic activity of 1-methyl 1,2,3,4-tetra-hydroisoquinoline and related compounds"Bioorg. Med. Chem. Lett.. 13. 2853-2855 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Kotake, et al.: "MPP+ analogs acting on mitochondria and inducing neuro-degeneration"Current Medicinal Chemistry. 10. 2507-2516 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Okuda, Y.Kotake, S.Ohta: "Determination method of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline, an endogenous parkinsonism-preventing substance, by radioimmunoassay"Life Sci.. 70. 2871-2883 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] A.Storch et al.: "Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease : studies using heterologous expression systems of the dopamine transporter"Biochem.Pharmacol.. 63. 909-920 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Kotake, et al.: "Nerotoxicity of an endogenous brain amine, 1-benzyl-1, 2, 3, 4-tetrahydroisoquin line, in organotypic slice co-culture of mesencephalon and striatum"Neuroscience. 117. 63-70 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Okuda, Y.Kotake, S.Ohta.: "Neuroprotective or neurotoxic activity of 1-methyl 1, 2, 3, 4-tetra-hydroisoquinoline and related compounds"Bioorg.Med.Chem.Lett.. 13. 2853-2855 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Kotake, S, Ohta: "MPP+ analogs acting on mitochondria and inducing neuro-degeneration"Current Medicinal Chemistry. 10. 2507-2516 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 太田 茂: "「パーキンソン病のすべて」パーキンソン病における神経毒"星和書店. 115-120 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] A.Storch: "Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease : studies using heterologous expression systems of the dopamine transporter"Biochem. Pharmacol.. 63. 909-920 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Okuda: "Determination method of 1-methyl-1,2,3,4-tetrahydroisoquinoline, an endogenous parkinsonism-preventing substance, by radioimmunoassay"Life Sci.. 70. 2871-2883 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Kotake: "Neurotoxicity of an endogenous brain amine, 1-benzyl-1,2,3,4-tetrahydroisoquinoline, in organotypic slice co-culture of mesencephalon and striatum"Neuroscience. 117. 63-70 (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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