| Project/Area Number |
14510102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
実験系心理学
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
TANAKA Gohichi Sapporo Medical University, School of Medicine, Associate Professor, 医学部, 助教授 (10167497)
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| Co-Investigator(Kenkyū-buntansha) |
KATOH Yuichi Sapporo Medical University, School of Medicine, Instructor, 医学部, 助手 (90363689)
SAWADA Yukihiro Sapporo Medical University, School of Medicine, Professor, 医学部, 教授 (40045539)
長野 祐一郎 札幌医科大学, 医学部, 助手 (00325870)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | arterial elasticity / pressure-volume function / aging / mental stress / reactive hyperemia / flow-mediated dilation / endotherial function / near-infrared spectroscopy / 暗算 |
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| Research Abstract |
A near-infrared finger photoplethysmogram adopting a wavelength of 810nm provides for the pulsatile ac component(ΔI) superimposed on the transmitted dc components in a normal (I:tissue plus blood) and an ischemic circulatory state (I_t:tissue only). Simultaneous recording of linger blood pressure provides for the distending pulse(PP) and mean blood pressure(MBP). Based on the Lambert Beer's law, indices of the arterial compliance (CI;= ΔI/I/PP) is advocated for the linger vasculature. We introduced the exponential pressure-volume model(V=a-b×exp(-nP)) and examined the effects of functional and structural variations in the vascular tone on these parameters. Experiment 1:Twelve female subjects underwent immersions of the contralateral hand in water at two different temperatures(44℃,22℃). CI calculated at 9OmmHg(CI90) of linear regression between log CI and MBP decreased significantly during 22℃ condition. Experiment 2:The functional relationship to the transmural pressure for CI was examined using linger-occlusion during mental arithmetics in sixteen females and reactive hyperemia in five. Logarithmically transformed CI was linearly associated with the transmural pressure. Changes in parameter a were most consistent among three parameters of the exponential model. Experiment 3:Age-associated differences in parameter a,b, and n were examined during resting condition between 31 young students and 9 middle aged workers. In the middle aged subjects, the model fitness deteriorated and only the parameter n was lowered compared with the young student. Parameter n was significantly correlated with brachial-ankle pulse wave velocity(baPWV) as a measure of arterial stiffness. Flow-mediated dilation(FMD) during reactive hyperemia at the wrist radial artery was recorded by oxygenated hemoglobin using near-infrared spectroscopy. Peak time of FMD was delayed in the young group as compared with the middle aged group and negatively correlated with baPWV.
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