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A role of monkey perirhinal cortex in relational memory and learning

Research Project

Project/Area Number 14510115
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 実験系心理学
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

YUKIE Masao  Tokyo Metropolitan Institute for Neuroscience, Dept. of Behavioral Physiology, Research Scientist, 東京都神経科学総合研究所, 研究員 (20113491)

Co-Investigator(Kenkyū-buntansha) YAMAGUCHI Kiyoko  Tokyo Metropolitan Institute for Neuroscience, Dept. of Behavioral Physiology, Research Scientist, 東京都神経科学総合研究所, 研究員 (10073090)
OSAWA Yasutaka  Tokyo Metropolitan Institute for Neuroscience, Dept. of Behavioral Physiology, Research Scientist, 東京都神経科学総合研究所, 研究員 (40100135)
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2005: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordsdelayed matching-to-sample task / a small set of stimuli / a large set of stimuli / transverse patterning task / relational association / configural association / perirhinal cortex / hippocampus / ニホンザル / 同時複式視覚弁別学習 / Transverse Patterning Problem / 要素連合 / 遅延見本合わせ課題 / 少数刺激セット条件 / 多数刺激セット条件 / 関係記憶・学習 / 両価手がかり弁別課題 / transverse patterning problem / 再認記憶 / サル / 視対象再認記憶
Research Abstract

To clarify roles of perirhinal cortex in memory and learning, especially in relational or configural ones, effects of perirhinal cortex lesion on delayed matching-to-sample tasks (DMS) with small (3 stimuli) and large (300 stimuli) sets of stimuli (DMS-S and DMS-L, respectively) and transverse patterning task (TPT) were examined using 6 macaque monkeys. Preoperatively, monkeys were trained on DMS-L and DMS-S. Postoperatively, DMS-S was first tested. Thereafter, DMS-L was given to the monkeys. Last, TPT and its control task, concurrent discrimination task (CDT), were trained. As a result, no impairment was seen in relearning of DMS-S or DMS-L or in their delay tests with 30, 60 and 120 sec. Perirhinal cortex lesion, however, produced a severe impairment in transverse patterning task without impairment in CDT. Our monkeys with perirhinal cortex lesion were not impaired in this task, despite that It is well-established that perirhinal cortex is critically involved in DMS-L. It might be possible that they resolved DMS-L by using their learned DMS-S strategy which remained intact.
The present results are sharply contrasted with our previous study demonstrating that monkey brain ischemia, which caused cell loss in the hippocampus, produced impairment in DMS-S, but not in DMS-L, TPT or CDT. It has been controversial whether TPT should be regarded as a configural task or as a relational one. However, perirhinal cortex lesion did not impair in DMS-S which might be regarded as a relational task, but in TPT. Thus, the present study suggests that perirhinal cortex might be involved in configural association, but not in relational association.

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (28 results)

All 2006 2005 2004 2003 Other

All Journal Article (20 results) Book (1 results) Publications (7 results)

  • [Journal Article] Distinctive morphology of hippocampal CA1 terminations in orbital and medial frontal cortex in macaque monkeys.2006

    • Author(s)
      Y Zhong, Y.M., Yukie, M., Rockland, K.S.
    • Journal Title

      Experimental Brain Research 17

      Pages: 1-5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Impairments in visual recognition for object and for location after transient brain ischemia in monkeys2006

    • Author(s)
      Yukie, M., Yamaguchi, K., Yamashima, T.
    • Journal Title

      Reviews in the Neuroscience 17

      Pages: 201-214

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transverse Patterning学習に及ぼすサル嗅周皮質摘除の効果-脳虚血による海馬損傷の効果との比較2006

    • Author(s)
      靱負正雄
    • Journal Title

      日本生理学精神生理学雑誌 24(印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Impairments in visual recognition for object and for location after transient brain ischemia in monkeys.2006

    • Author(s)
      Yukie, M., Yamaguch, K., Yamashima, T.
    • Journal Title

      Reviews in the Neuroscience 17

      Pages: 201-214

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Distinctive morphology of hippocampal CA1 terminations in orbital and medial frontal cortex in macaque monkeys.2006

    • Author(s)
      Zhong, Y., Yukie.M., Rockland, K.S
    • Journal Title

      Experimental Brain Research 169巻4号

      Pages: 549-553

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Impairments in recognition memory for object and for location after transient brain ischemia in monkeys.2006

    • Author(s)
      Yukie, M., Yamaguchi, K., Yamashima, T.
    • Journal Title

      Reviews in the Neurosciences 17巻(印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Adult hippocampal neurogenesis in rodents and primates : enodogenous, enhanced, and engrafted.2006

    • Author(s)
      Yamashima, T., Tonchev, A.B., Yukie, M.
    • Journal Title

      Reviews in the Neurosciences 17巻(印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Direct projections from CA1 to the superior temporal sulcus in the monkey, revealed by single axon analysis.2005

    • Author(s)
      Y Zhong, Y.M., Yukie, M., Rockland, K.S.
    • Journal Title

      Brain Research 1035

      Pages: 211-214

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Direct projections from CA1 to the superior temporal sulcus in the monkey, revealed by single axon analysis.2005

    • Author(s)
      Zhong, Y., Yukie, M., Rockland, K.S.
    • Journal Title

      Brain Research 1035

      Pages: 211-214

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Distinctive morphology of hippocampal CA1 termination in orbital and medial frontal cortex in macaque monkeys.2005

    • Author(s)
      Zhong, Y.M., Yukie, M., Rockland, K.S.
    • Journal Title

      Experimental Brain Research 17

      Pages: 1-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Direct projections from CA1 to the superior temporal sulcus in the monkey, revealed by single axon analysis.2005

    • Author(s)
      Zhong, Y., Yukie.M., Rockland, K.S
    • Journal Title

      Brain Research 1035巻

      Pages: 211-214

    • Related Report
      2005 Annual Research Report
  • [Journal Article] サル脳虚血のTransverse Patterning Problemの学習に及ぼす効果について2005

    • Author(s)
      靭負正雄
    • Journal Title

      生理心理学と精神生理学 23巻2号

      Pages: 118-118

    • Related Report
      2005 Annual Research Report
  • [Journal Article] TE野とTF/TH野同時損傷が図形再学習及び保持に及ぼす影響-過剰訓練ザルによる検討-2005

    • Author(s)
      大沢康隆, 山口清子, 靭負正雄
    • Journal Title

      日本心理学会第69回大会発表論文集 69巻

      Pages: 423-423

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Direct projections from CA1 to the superior temporal sulcus in the monkey, revealed by single axon analysis.2005

    • Author(s)
      Zhong, Y., Yukie, M., Rockland, KS.
    • Journal Title

      Brain Research 1035

      Pages: 211-214

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ヒトにおける両価手がかり弁別課題遂行中の海馬活動:機能的MRIによる検討2004

    • Author(s)
      野中博意, 野瀬出, 安部博史, 山口友美, 泰羅雅登, 靱負正雄
    • Journal Title

      生理心理学と精神生理学 22・2

      Pages: 162-162

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 右前頭葉に損傷を有する脳外傷児一事例の前頭葉機能について2004

    • Author(s)
      山口友美, 小林寛子, 靱負正雄, 小林久男
    • Journal Title

      生理心理学と精神生理学 22・2

      Pages: 205-205

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cortical terminations of hippocampal projections from CA1 in macaque monkeys2004

    • Author(s)
      Yukie, M., Zhong, Y., Konagaya, H., Rockland, K.S.
    • Journal Title

      Neuroscience Research 50・Suppl.1

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Differential thalamic connections of the posteroventral and dorsal posterior cingulate gyrus in the monkey.2003

    • Author(s)
      Shibata, H, Yukie, M.
    • Journal Title

      European Journal of Neuroscience 18

      Pages: 1615-1626

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differential thalamic connections of the posteroventral and dorsal posterior cingulate gyrus in the monkey.2003

    • Author(s)
      Shibata, H., Yukie, M.
    • Journal Title

      European Journal of Neuroscience 18

      Pages: 1615-1626

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of perirhinal cortex lesion on transverse learning in monkeys

    • Author(s)
      Yukie, M.
    • Journal Title

      Japanese Journal of physiological psychology and psychophysiology (in Japanese) (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 自閉症の子どもたち-間主観性の発達心理学からのアプローチ- (第6章脳の発達と自閉症、第7章自閉症における脳異常)(翻訳書)2005

    • Author(s)
      Travarthen著(中野茂ら監修)
    • Publisher
      ミネルヴァ書房
    • Related Report
      2005 Annual Research Report
  • [Publications] Shibata, H, Yukie, M.: "Differential thalamic connections of the posteroventral and dorsal posterior cingulate gyrus in the monkey."European Journal of Neuroscience. 18. 1615-1626 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 靱負正雄, 山口清子: "サル脳虚血の少数および多数位置条件の空間再認記憶に及ぼす効果"生理心理学と精神生理学. 21. 145 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kolwyn Travarthen ら: "共感する心と自閉症(監訳者:中野茂・近藤清美・伊藤良子)"みすず書房(印刷中). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Masao Yukie: "Connections between the amygdala and auditory cortical areas in the macaque monkey"Neuroscience Research. 42. 219-229 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 靭負正雄, 山口清子: "サル全脳一時虚血後に見られる視覚性記憶障害"日本心理学会第66回大会論文集. 66. 342 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yukie, M., Konagaya, H., yamaguchi, K., Yamashima, T: "Effects of ischemia on delayed matching to sample with small and large sets of stimuli in Japanese monkeys"Neuroscience Reserch. Suppl.26. S202 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 山口清子, 靱負正雄: "視対象再認記憶に及ぼすサル全脳一時虚血の効果"生理心理学と精神心理学. 20・2. 103 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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