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Analysis of Phase Separation Dynamics of Multilayer Lipid-Membrane System on the basis of Higher-Dimensional Vicinal-Surface Picture

Research Project

Project/Area Number 14540370
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 物理学一般
Research InstitutionGunma University

Principal Investigator

YAMAMOTO Takao  Gunma University, Faculty of Engineering, Professor, 工学部, 教授 (80200814)

Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordshigher-dimensional vicinal surface picture / long wave-length thermal fluctuation / inter-membrane distance distribution function / multilayer lipid membrane / non-crossing effect / Monte Carlo simulation / exponential-type relaxation / fluctuation instability / 非解析的ランダウ展開 / 凝集不安定性 / 凝集多層膜 / Persistence Length / 非平衡熱力学 / Monte-Carloシミュレーション / 自己無撞着調和近似
Research Abstract

1.Expressing the multilayer lipid membrane system in terms of the higher-dimensional vicinal surface picture, I showed that the dominant term in the "dispersion" of the long wave-length fluctuation should be proportional to the square of the lateral wave number, and I verified it by a Monte Carlo simulation.
2.To discuss the non-crossing effect of the multilayer membrane system, I generalized the membrane picture and proposed a method translating the two-dimensional membrane system into a one-dimensional string system.
3.I proposed a method expressing the free energy increment due to the membrane-membrane interaction potential in terms of the inter-membrane distance distribution (IMDD) function. The IMDD function was obtained by a Monte Carlo calculation.
4.The phase diagrams exhibited by the multilayer membrane systems with attractive interaction were obtained. The phase coexistence between the phase composed of the solvent alone and the phase with finite membrane density (the membrane condensation) appears. The dynamics of the membrane condensation also analyzed by the Ginzburg-Landau equation.
5.The thermal instability of the "flat" membrane condensation phase was found.
6.The non-analytic Landau expansion method was developed.
7.A generalized expression for permeability of molecules through membrane was derived.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] C.P.Cahng, T.Yamamoto, M.Kimura, T.Sato, K.Ichikawa, T.Dobashi: "Release characteristics of an azo-dye from poly(ureaurethane) microcapsules."Journal of Controlled Release. 86. 207-211 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Sato, S.Shibako, T.Yamamoto, K.Ichikawa, T.Dobashi: "Permeability of azo-dye through poly(ureaurethane) microcapsule"Journal of Membrane Science. 213. 25-31 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Narita, T.Yamamoto, D.Suzuki, T.Dobashi: "Dynamics of the Volume Phase Transition of Hydrogel Membrane of a Microcapsule"Langmuir. 19. 4051-4054 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Yamamoto, T.Narita, M.Nobe, T.Dobashi: "Free Energy of Mixing for Polymer Solutions"Macromolecules. 37. 3475-3486 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takao Yamamoto, Yukitoshi Iwamoto: "Membrane-Membrane Interaction and Free Energy of Multilayer Membrane System"AIP Conference series. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Yamamoto, T.Narita, M.Nobe, T.Dobashi: "Reentrant volume phase transition of hydrogel membrane of microcapsule"Colloids and Surfaces B : Biointerfaces. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] C.P.Chang, M.Kimura, T.Yamamoto, T.Dobashi: "Effect of Dispersing Medium on Permeability of Microcapsule Membrane"Colloids and Surfaces B : Biointerfaces. 30. 123-127 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Narita, T.Yamamoto, E.Hosoya, T.Dobashi: "Gibbs free energy expression for the system polystyrene in methylcyclohexane and its application to microencapsulation"Langmuir. 19. 5240-5245 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] C.P.Cahng, T.Yamamoto, M.Kimura, T.Sato, K.Ichikawa, T.Dobashi: "Release characteristics of an azo-dye from poly(ureaurethane) microcapsules."Journal of Controlled Release. Vol.86. 207-211 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Sato, S.Shibako, T.Yamamoto, K.Ichikawa, T.Dobashi: "Permeability of azo-dye through poly(ureaurethane) microcapsule"Journal of Membrane Science. Vol.213. 25-31 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Narita, T.Yamamoto, D.Suzuki, T.Dobashi: "Dynamics of the Volume Phase Transition of Hydrogel Membrane of a Microcapsule."Langmuir. Vol.19. 4051-4054 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Yamamoto, T.Narita, M.Nobe, T.Dobashi: "Free Energy of Mixing for Polymer Solutions."Macromolecules. Vol.37. 3475-3486 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takao Yamamoto, Yukitoshi Iwamoto: "Membrane-Membrane Interaction and Free Energy of Multilayer Membrane System."AIP Conference series. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Yamamoto, T.Narita, M.Nobe, T.Dobashi: "Reentrant volume phase transition of hydrogel membrane of microcapsule."Colloids and Surfaces B : Biointerfaces. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] C.P.Chang, M.Kimura, T.Yamamoto, T.Dobashi: "Effect of Dispersing Medium on Permeability of Microcapsule Membrane."Colloids and Surfaces B : Biointerfaces. Vol.30. 123-127 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Narita, T.Yamamoto, E.Hosoya, T.Dobashi: "Gibbs free energy expression for the system polystyrene in methylcyclohexane and its application to microencapsulation"Langmuir. Vol.19. 5240-5245 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takao Yamamoto, Yukitosi Iwamoto: "Membrane-Membrane Interaction and Free Energy of Multilayer Membrane System"AIP Conference series. (印刷中).

    • Related Report
      2003 Annual Research Report
  • [Publications] Takao Yamamoto, Toshiaki Dobashi, Daisuke Suzuki, Takayuki Narita: "Reentrant volume phase transition of hydorogel membrane of microcapsule"Colloids and Surfaces B : Biointerfaces. (印刷中).

    • Related Report
      2003 Annual Research Report
  • [Publications] Takao Yamamoto, Takayuki Narita, Masahiro Nobe, Toshiaki Dobashi: "Free Energy of Mixing for Polymer Solutions"Macromolecules. (印刷中).

    • Related Report
      2003 Annual Research Report
  • [Publications] C.P.Chang, T.Yamamoto, M.Kimura, T.Sato, K.Ichikawa, T.Dobashi: "Release characteristics of an azo-dye from poly (ureaurethane) microcapsules"Journal of Controlled Release. Vol.86. 207-211 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Sato, S.Shibako, T.Yamamoto, K.Ichikawa, T.Dobashi: "Permeability of azo-dye through poly (ureaurethane) microcapsule membrane"Journal of Membrane Science. Vol.213. 25-31 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Furukawa, S.C.Hung, T.Yamamoto, K.Terao, K.Ichikawa, T.Dobashi: "Effect of Affinity between Core Medium and Wall Membrane on Permeability of Dye through Microcapsule Membrane"Transactions of the Materials Research Society of Japan. (掲載予定).

    • Related Report
      2002 Annual Research Report
  • [Publications] C.P.Chang, M.Kimura, T.Yamamoto, T.Dobashi: "Effect of Dispersing Medium on Permeability of Microcapsule Membrane"Colloids and Surfaces B : Biointerfaces. (掲載予定).

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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