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Formation of polyamino acids in the prebiotic conditions : production mechanisms and structures.

Research Project

Project/Area Number 14540455
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 地球化学
Research InstitutionUniversity of Tsukuba

Principal Investigator

MITA Hajime  University of Tsukuba, Department of Chemistry, Research Associate, 化学系, 助手 (00282301)

Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥2,800,000 (Direct Cost: ¥2,800,000)
Keywordsprebiotic condition / polyamino acid / chemical evolution / molten urea / polyalanine / aspargine / polyaspartic acid / ESI-MS / 物質進化 / 熔融尿素
Research Abstract

It is important for research of the origins of life to elucidate polyamino acid formation in the prebiotic conditions. Only a limited set of amino acids has been reported to polymerize thermally.
In this study, oligopeptides formed in the heating experiments of aqueous aspargine and ureaamino acids mixtures were characterized individually using a liquid chromatograph-mass spectrometer. Cooligomerization of aspargine and other amino acids were well characterized as the amide exchange mechanism proposed in our previous paper. We also demonstrate a novel thermal polymerization in molten urea of alkylamino acids (i.e.glycine, alanine, α-alanine, β-aminobutyric acid, valine, norvaline, leucine, and norleucine) which had been thought to be incapable of undergoing thermal polymerization. Also, aspartic acid was found to polymerize in molten urea at a lower temperature than that at which aspartic acid alone had previously been thermally polymerized. The polymerization reaction occurred by taking advantage of molten urea's high polarity as well as its dehydrating ability. Under the presumed prebiotic conditions employed here, many types of amino acids were thus revealed to undergo thermal polymerization.
Some novel information of polyamino acid formation in the prebiotic conditions were obtained through this study. In addition, we found some directivity in future research for the study of origins of life.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Terasaki, M. et al.: "A new thermal polycondensation of alanine in moleten urea."Chem.Lett. 480-481 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Terasaki, M. et al.: "Flame-induced addition of urea to unsaturated carboxylic acids."Bull.Chem.Soc.Jpn.. 75. 855-856 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Terasaki, M. et al.: "A new pathway to aspartic acid from urea and maleic acid affected by ultraviolet light."Origin.Life Evol.Biosphere. 32. 91-98 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kozono, M. et al.: "2-Ethyl-3-methylmaleimide in Tokyo Bay sediments providing the first evidence for its formation from chlorophylls in the present photic and oxygeneic zone."Biosci.Biotechnol.Biochem. 66. 1844-1847 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nomoto, S. et al.: "Hydrogen-oxygen flame as a radical source for aqueous-phase reaction : Carboxylation of propylamine in aqueous formic acid solution."Photo/Electrochemistry and Photobiology for Environment, Energy and Fuel. 2. 119-129 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Terasaki, M. et al.: "Adsorption of saturated dicarboxylic acids and their amides on a clay mineral."Photo/Electrochemistry and Photobiology for Environment, Energy and Fuel. 2. 147-154 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shimoyama, A. et al.: "Analyses of organic compounds and stable carbon isotope ratios in the simulated MUSES-C samples."Inst.Space and Astronaut.Sci.Rep.SP. 16. 119-133 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Terasaki, M. et al.: "Formation of N-carbamoylalanine from urea and pyruvic acid in aqueous formic acid."Viva Origino. 32. 53-59 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mita, H. et al.: "Kinetic study of abiotic amino acid formation by UV irradiation."Αδω.Σπαχε.Ρεσ.. 印刷中.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Naraoka, H. et al.: "A chemical sequence of macromolecular organic matter in the CM chondrites."Meteoritics and Planetary Science. 印刷中.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Terasaki, M., Nomoto, S., Mita, H., Shimoyama, A.: "A new thermal polycondensation of alanine in molten urea."Chem.Lett.. 480-481 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Terasaki, M., Nomoto, S., Mita, H., Shimoyama, A.: "Flame-induced addition of urea to unsaturated carboxylic acids."Bull.Chem.Soc.Jpn.. 75. 855-856 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Terasaki, M., Nomoto, S., Mita, H., Shimoyama, A.: "A new pathway to aspartic acid from urea and maleic acid affected by ultraviolet light."Origins Life Evol.Biosphere. 32. 91-98 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kozono, M, Nomoto, S, Mita, H., Ishiwatari, R., Shimoyama, A.: "2-Ethyl-3-methylmaleimide in Tokyo Bay sediments providing the first evidence for its formation from chlorophylls in the present photic and oxygeneic zone."Biosci.Biotechnol.Biochem.. 66. 1844-1847 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nomoto, S., Yoshimura, D., Hagiwara, M., Kozono, Terasaki, M., Oba, M., Shiraishi, S., Mita, H.: "Hydrogen-oxygen flame as a radical source for aqueous-phase reaction : Carboxylation of propylamine in aqueous formic acid solution."Photo/Electrochemistry and Photobiology for Environment, Energy and Fuel. 2. 119-129 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Terasaki, M., Mita, H., Nomoto, S., Shimoyama, A.: "Adsorption of saturated dicarboxylic acids and their amides on a clay mineral."Photo/Electrochemistry and Photobiology for Environment, Energy and Fuel. 2. 147-154 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shimoyama, A., Naraoka, H., Mita, H., Komiya, M.: "Analyses of organic compounds and stable carbon isotope ratios in the simulated MUSES-C samples."Inst.Space and Astronaut.Sci.Rep.SP. 16. 119-133 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Terasaki, M., Nomoto, S., Mita, H., Shimoyama, A.: "Formation of N-carbamoylalanine from urea and pyruvic acid in aqueous formic acid."Viva Origino. 32. 53-59 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mita, H., Shirakura, N., Yokoyama, H., Nomotos, S., Shimoyama, A.: "Kinetic study of abiotic amino acid formation by UV irradiation."Adv.Space Res.. January(Web published). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Naraoka, H., Mita, H., Komiya, M., Yoneda, S., Kojima, H., Shimoyama, A.: "A chemical sequence of macromolecular organic matter in the CM chondrites."Meteoritics and Planetary Science. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kozono, M.et al.: "2-Ethyl-3-methylmaleimide in Tokyo Bay sediments providing the first evidence for its formation from chlorophylls in the present photic and oxygeneic zone"Biosci.Biotechnol.Biochem. 66. 1844-1847 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nomoto, S., et al.: "Hydrogen-oxygen flame as a radical source for aqueous-phase reaction : Carboxylation of propylamine in aqueous formic acid solution"Photo/Electrochemistry and Photobiology for Environment, Energy and Fuel. 2. 119-129 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Terasaki, M.et al.: "Adsorption of saturated dicarboxylic acids and their amides on a clay mineral"Photo/Electrochemistry and Photobiology for Environment, Energy and Fuel. 2. 147-154 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shimoyama, A.et al.: "Analyses of organic compounds and stable carbon isotope ratios in the simulated MUSES-C samples"Inst.Space and Astronaut.Sci.Rep.SP. 16. 119-133 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Terasaki, M.et al.: "Formation of N-carbamoylalanine from urea and pyruvic acid in aqueous formic acid"Viva Origino. 32. 53-59 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mita, H.et al.: "Kinetic study of abiotic amino acid formation by UV irradiation"Adv.Space Res.. (印刷中).

    • Related Report
      2003 Annual Research Report
  • [Publications] Terasaki, M., et al.: "A New Thermal Polycondensation of Alanine in Molten Urea"Chemistry Letters. 480-481 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Terasaki, M., et al.: "Flame-induced addition of urea to unsaturated carboxylic acids"Bulletin of the Chemical Society of Japan. 75. 855-856 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Terasaki, M., et al.: "A new pathway to aspartic acid from urea and maleic acid affected by ultraviolet light"Origins of Life and Evolution of the Biosphere. 32. 91-98 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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