| Project/Area Number |
14550781
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
工業分析化学
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| Research Institution | Nagoya University |
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Principal Investigator |
SAITOH Tohru Nagoya University, Graduate School of Engineering, Associate professor, 工学研究科, 助教授 (40186945)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | micro-analytical system / flow control / wettability / thermo-responsive polymer / octadecylsilane / frost work / responsibility against chemicals / glucose / ビニルフェニルホウ酸 / イソプロピルアクリルアミド / 高分子 / 親水-疎水変換 / 表面修飾 / 保持の制御 |
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| Research Abstract |
In this decade, micro-analytical systems composing of fabricated micro-channels on chips has extremely investigated and applied to the wide areas. In the present study, a novel methodology for the fluid control complicate micro-channels was developed. The stimuli-responsive polymer that changes its hydrophilic-hydrophobic properties by stimuli was used to modify the wall of channels. The modification was successfully achieved by binding silane coupling agent on glass walls and the subsequent aqueous radical co-polymerization of N-isopropylacrylamide and a certain monomer having functional group that can bind to the objective compound. I could successfully control the surface wettability by stimuli such as temperature, salt, or surfactants. The wettability change results in the on-off of the stream or switching the flow direction. The contrast of the wettability was significantly improved by the modification with highly hydrophobic octadecylsilane accompanying with stimuli-responsive polymer. Furthermore, the modification onto the surfaces having sub-micro meter order of asperity was quite effective for obtaining-both of highly wettable and waters repellent surfaces. The polymer containing carboxyl or imidazole moieties can varied the hydrophilic-hydrophobic properties depending on the acid-alkaline conditions. The polymer including phenylborate substituents that can bind to sugar could not respond against glucose. On the other hand, the hydrophobicity of the polymer having the both of phenylborate and dimethylamino groups increased by the presence of glucose. The modification by such stimuli-responsive polymer will be effective for making glucose-responsive flow control system.
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