| Project/Area Number |
14550820
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
IKEDA Hiroshi Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Assistant Professor, 大学院・生命理工学研究科, 助手 (70201910)
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| Project Period (FY) |
2002 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2004: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Cyclodextrin / Supramolecule / Regulation of Activity / Allosteric Effect / Transport through a Liquid Membrane / Hydrogen Bond / ドラッグデリバリ |
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| Research Abstract |
A new efficient system for transporting saccharides through a liquid membrane has been constructed. The transport rates of saccharides were accelerated greatly by the cyclodextrin dimer 2;by contrast, the corresponding cyclodextrin monomer 1 was not effective at mediating saccharide transport. The transport rate of D-ribose through a chloroform liquid membrane was 17 times faster when the cyclodextrin dimer 2 was used as the transporter than when the cyclodextrin monomer 1 was used. Similarly the transport rate of methyl D-galactopyranoside was 16 times faster by 2 than by 1. The mechanism of transporting saccharides by this effective transporter was investigated with ^1H NMR.
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