| Project/Area Number |
14560027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
園芸・造園学
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| Research Institution | Akita Prefectural University |
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Principal Investigator |
YOSHIZAWA Yuko Akita Prefectural University, Biotechnology, Associate Professor, 生物資源科学部, 助教授 (20269202)
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| Co-Investigator(Kenkyū-buntansha) |
SAKURAI Kenji Akita Prefectural University, Biotechnology, Assistant, 生物資源科学部, 助手 (00315607)
MUROFUSHI Noboru Akita Prefectural University, Biotechnology, Professor, 生物資源科学部, 教授 (00011916)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥3,100,000 (Direct Cost: ¥3,100,000)
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| Keywords | Crabapple / Antiproliferation / HL-60 / DPPH / Polyphenol / Antioxidant / Apple / がん予防 |
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| Research Abstract |
Juices prepared from 42 crabapples (Malus spp.) were studied attempting to explore their antiproliferative activity. Most of the juices examined showed strong inhibition of the proliferation of HL-60 human leukemia cells. The amounts of total anthocyanins and total phenolics, as well as DPPH radical scavenging activity were measured. The antiproliferative effect was more correlated to the amount of polyphenol and DPPH radical scavenging activity than of anthocyanins. The results suggested that utilizing crabapple juice as a processed food and beverage contributes to the maintenance of good health. Juices prepared from 19 apple cultivars were also studied on proliferation of HL-60. A half of them showed strong inhibition, while the others were weak. A careful examination on parentage of apple cultivars tested revealed that a cultivar 'Jonathan' and its progenies showed high antiproliferation toward HL-60. This is the first observation about the relationship between antiproliferative activity and parentage of apples, and the information would be useful to create new apple cultivars which posses more anticancer potential.
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