Research on regulation of absorption and metabolism of sterols by ABC transporters
| Project/Area Number |
14560102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
食品科学・栄養科学
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| Research Institution | Kyushu University |
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Principal Investigator |
IKEDA Ikuo Kyushu University, Faculty of Agriculture, Associate professor, 農学研究院, 助教授 (40136544)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 2003: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2002: ¥3,600,000 (Direct Cost: ¥3,600,000)
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| Keywords | ABCG5 / ABCG8 / SHRSP rats / plant sterols / absorption / LXR / LXR agonist / Liver X receptor / コレステロール / Liver X receptorアゴニスト / 高植物ステロール血症 / WKYラット |
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| Research Abstract |
We found that SHRSP rats, which deposit plant sterols in their body, have a point mutation on ATP binding cassette transporter (ABC)G 5. ABCG5 and G8 form a heterodimer and have a function to excrete cholesterol and plant sterols from intestine and liver. Since the function of ABCG5 and G8 is insufficient in SHRSP rats, plant sterols may be deposited in their body. Expression of ABCG5 and G8 is regulated by liver X receptor. In the next study, LXR agonist was fed to SHRSP and normal rats together with plant sterols. Although expression of ABCG5 and G8 in the intestine of SHRSP and normal rats was increased by the feeding of LXR agonist, plant sterols in the liver of SHRSP rats were hardly reduced. In contrast, deposition of plant sterols in the liver of normal rats was reduced. The results strongly suggest that SHRSP rats can hardly excrete plant sterols from their body. Expression of ABCG5 and G8 in the liver was not stimulated by the feeding of LXR agonist in SHRSP rats. This may be one of the reasons by which plant sterols in the liver of SHRSP rats was not reduced by the feeding of LXR agonist.
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Report
(3 results)
Research Products
(2 results)
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[Publications] HongWei Yu, Bhaewati Pandit, Eric Klett, Mi-Hye Lee, Kangmo Lu, Khalil Helou, Ikuo Ikeda, Nami Egashira, Masao Sato, Richard Klein, Ashok Batta, Gerald Salen, Shailendra B.Patel: "The rat STSL locus : characterization, chromosomal assignment, genetic variations in sitosterolemic hypertensive rats"BMC (BioMed Central) Cardiovascular Disorders. 3. 4 (2003)
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