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Research on regulation of absorption and metabolism of sterols by ABC transporters

Research Project

Project/Area Number 14560102
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 食品科学・栄養科学
Research InstitutionKyushu University

Principal Investigator

IKEDA Ikuo  Kyushu University, Faculty of Agriculture, Associate professor, 農学研究院, 助教授 (40136544)

Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 2003: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2002: ¥3,600,000 (Direct Cost: ¥3,600,000)
KeywordsABCG5 / ABCG8 / SHRSP rats / plant sterols / absorption / LXR / LXR agonist / Liver X receptor / コレステロール / Liver X receptorアゴニスト / 高植物ステロール血症 / WKYラット
Research Abstract

We found that SHRSP rats, which deposit plant sterols in their body, have a point mutation on ATP binding cassette transporter (ABC)G 5. ABCG5 and G8 form a heterodimer and have a function to excrete cholesterol and plant sterols from intestine and liver. Since the function of ABCG5 and G8 is insufficient in SHRSP rats, plant sterols may be deposited in their body. Expression of ABCG5 and G8 is regulated by liver X receptor. In the next study, LXR agonist was fed to SHRSP and normal rats together with plant sterols. Although expression of ABCG5 and G8 in the intestine of SHRSP and normal rats was increased by the feeding of LXR agonist, plant sterols in the liver of SHRSP rats were hardly reduced. In contrast, deposition of plant sterols in the liver of normal rats was reduced. The results strongly suggest that SHRSP rats can hardly excrete plant sterols from their body. Expression of ABCG5 and G8 in the liver was not stimulated by the feeding of LXR agonist in SHRSP rats. This may be one of the reasons by which plant sterols in the liver of SHRSP rats was not reduced by the feeding of LXR agonist.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] H.Yu et al.: "The rat STSL locus : characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats"BMC Cardiovascular Disorders. 3. 4 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] HongWei Yu, Bhaewati Pandit, Eric Klett, Mi-Hye Lee, Kangmo Lu, Khalil Helou, Ikuo Ikeda, Nami Egashira, Masao Sato, Richard Klein, Ashok Batta, Gerald Salen, Shailendra B.Patel: "The rat STSL locus : characterization, chromosomal assignment, genetic variations in sitosterolemic hypertensive rats"BMC (BioMed Central) Cardiovascular Disorders. 3. 4 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary

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Published: 2002-04-01   Modified: 2016-04-21  

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