Eucalyptus polyphenols inhibit intestinal fructose absorption, prevent adiposity, and improve diabetes mellitus

• Project/Area Number: 14560107
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 食品科学・栄養科学
• Research Institution: Osaka Prefecture University
• Principal Investigator: INUI Hiroshi Osaka Prefecture University, Department of Applied Biological Chemistry, Associate Professor, 農学生命科学研究科, 助教授 (20193568)
• Co-Investigator(Kenkyū-buntansha): NAKANO Yoshihisa Osaka Prefecture University, Department of Applied Biological Chemistry, Professor, 農学生命科学研究科, 教授 (20081581)
• Project Period (FY): 2002 – 2004
• Project Status: Completed (Fiscal Year 2004)
• Budget Amount: ¥3,400,000 (Direct Cost: ¥3,400,000); Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000); Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000); Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: Sucrose / Fructose / Obesity / Diabetes mellitus / Polyphenols / Eucalyptus / スクロース摂取 / 高脂血症 / スクラーゼ阻害 / 腸管フルクトース吸収 / エンドトキシンショック / 加水分解性タンニン / NO合成酵素 / 腸管フルクトース吸収阻害 / GLUT5 / 脂質合成の活性化

Research Abstract

Sucrose is more lipogenic than starch, and the extreme ingestion of sucrose induces adiposity and obesity. The aim of this study was to examine the effect of the eucalyptus (Eucalyptus globulus) leaf extract (ELE) on adiposity due to dietary sucrose in rats. In addition, in this study, the effect of ELE on intestinal fructose absorption was also examined. Rats were fed a high-sucrose diet (75% in calorie base) with or without ELE (10 g/kg of diet) for 5 weeks. Body weight was lower in the rats receiving ELE than in the controls (342 (SD 37.9) versus 392 (SD 26.0) g (n 7) ; P<0.05). Furthermore, ELE resulted in decreases in the triacylglycerol concentrations in the plasma (1.44 (SD 0.448) versus 2.79 (SD 0.677) mmol/l (n 7) ; P<0.05) and liver (19.1 (SD 5.07) versus 44.1 (SD 16.28) μmol/g (n 7) ; P<0.05). In contrast, ELE did not show any significant effects in the rats fed a starch diet. When rats were orally given ELE 10 min before fructose administration, the intestinal fructose absorption, which was examined by measuring the elevated concentration of fructose in the portal vein at 30 mm after the fructose administration, was significantly inhibited in a dose-dependent manner. Furthermore, in rats fed a high-fructose diet, the plasma and hepatic triacylglycerol concentrations were significantly decreased by ELE. These results indicate that ELE, that inhibits the intestinal fructose absorption, can suppress adiposity in rats that ingest large amounts of sucrose or fructose.

Research Products

• [Journal Article] Eucalyptus leaf extract inhibits intestinal fructose absorption, and suppresses adiposity due to dietary sucrose (2005)
  • Author(s): Sugimoto, K., Inui, H., Nakano, Y.et al.
  • Journal Title: British Journal of Nutrition (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Eucalyptus leaf extract inhibits intestinal fructose absorption, and suppresses adiposity due to dietary sucrose in rats (2005)
  • Author(s): Sugimoto, K., Suzuki, J., Nakagawa, K., Hayashi, S., Enomoto, T., Fujita, T., Yamaji, R., Inui, H., Nakano, Y.
  • Journal Title: British Journal of Nutrition (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Eucalyptus leaf extract inhibits intestinal fructose absorption, and suppresses adiposity due to dietary sucrose in rats (2005)
  • Author(s): Sugimoto, K., Inui, H., Nakano, Y.et al.
  • Journal Title: British Journal of Nutrition (印刷中)