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Establishment of genetically dilated cardiomyopathy and usefulness of imidazoline receptor-acting agents in dogs

Research Project

Project/Area Number 14560266
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionNational University Corporation Tottori University

Principal Investigator

HIKASA Yoshiaki  Tottori University, Faculty of Agriculture, Professor, 農学部, 教授 (30165071)

Co-Investigator(Kenkyū-buntansha) MATSUDA Hiroshi  Tokyo University of Agriculture and Technology, Faculty of Agriculture, Professor, 農学部, 教授 (80145820)
YAMANO Yoshiaki  Tottori University, Fac of Agr., Associate Professor, 農学部, 助教授 (00182593)
MORITA Takehito  Tottori University, Fac of Agr., Associate Professor, 農学部, 助教授 (70273901)
佐藤 耕太  鳥取大学, 農学部, 講師 (50283974)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2004: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsDog / Platelet / Dilated cardimyopathy / Imidazoline receptor / Cardiovascular system / Genetics / Adrenoceptor / Catecholamine / カルニチン / タウリン / 心筋症
Research Abstract

The present study was conducted to investigate the pharmacological characteristics of imidazoline receptors on platelets and cardiovascular systems in dogs. In addition, the genetically dilated cardiomyopathy in the dog, American cocker spaniel, was established, and the usefulness of imidazoline receptor acting agents for the dilated caridiomyopathy dog was examined. The results demonstrated that two subtypes of non-adrenergic I receptors, I_1 and I_2, as well as the α_<2A>-adrenoceptor subtype exists on canine platelets. In addition, this study suggested that I_1 subtype was coupled with GTP-binding proteins, and I_2 was not coupled with those. As imidazoline receptor acting agents inhibit the adrenaline-potentiated platelet aggregation in dogs, and induce vascular dilatation, imidazoline receptor agents may be useful for the treatment of thrombosis and caridiovascular diseases. This study revealed the process and pathophysiology of the dilated caridiomyopathy dog. Furthermore, the results of α_2-adrenoceptor and imidazoline receptor binding and the plasma catecholamine measurements in canine dilated caridiomyopathy revealed that significant negative correlations were observed for reduced number of α_2-adrenoceptors on platelets, and increased plasma adrenaline concentrations. However, the correlation between the reduced number of I_1- and I_2-receptors on platelets and the plasma catecholamine concentrations was not significant. Therefore, these results indicated that I_1- and I_2-receptor acting agents compared with α_2-adrenergic agents may be more useful for the treatment of cardiovascular disease in dogs. Further studies may be required to investigate the function of I_1 and I_2 receptors in canine cardiomyopathy.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (21 results)

All 2005 2003 2002 1999 Other

All Journal Article (14 results) Publications (7 results)

  • [Journal Article] Influence of medetomidine on stress-related neurohormonal and metabolic effects caused by butorphanol, fentanyl and ketamine in dogs2005

    • Author(s)
      Tamas Ambrisko
    • Journal Title

      American Journal of Veterinary Research 66・3

      Pages: 406-412

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Influence of medetomidine on stress-related neurohormonal and metabolic effects caused by butorphanol, fentanyl and ketamine in dogs2005

    • Author(s)
      Tamas Ambrisko
    • Journal Title

      American Journal of Veterinary Research 66(3)

      Pages: 406-412

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The Influence of Medetomidine on Stress-related Neurohormonal and Metabolic Effects Caused by Butorphanol, Fentanyl, and Ketamine Administration in Dogs2005

    • Author(s)
      T.D.Ambrisko
    • Journal Title

      American Journal of Veterinary Research 66・3(In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Chronic Myocardial Infarction Due to Arteriosclerosis of Coronary Arteries Followed by Acute Thromboembolism of Caudal Abdominal Aorta in a Cat2005

    • Author(s)
      K.Tsujino
    • Journal Title

      Journal of Veterinary Medical Sciences 67(In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The antagonistic effects of atipamezole and yohimbine on stress-related neurohormonal and metabolic responses induced by medetomidine in dogs2003

    • Author(s)
      Tamas Ambrisko
    • Journal Title

      Canadian Journal of Veterinary Research 67・1

      Pages: 64-67

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The antagonistic effects of atipamezole and yohimbine on stress-related neurohormonal and metabolic responses induced by medetomidine in dogs2003

    • Author(s)
      Tamas Ambrisko
    • Journal Title

      Canadian Journal of Veterinary Research 67(1)

      Pages: 64-67

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Neurohormonal and metabolic effects of medetomidine compared with xylazine in beagle dogs2002

    • Author(s)
      Tamas Ambrisko
    • Journal Title

      Canadian Journal of Veterinary Research 66・1

      Pages: 42-49

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cardiopulmonary, hematological, serum biochemical and behavioral effects of sevoflurane compared with isoflurane or halothane in spontaneously ventilating goats2002

    • Author(s)
      Yoshiaki Hikasa
    • Journal Title

      Small Ruminant Research 43・2

      Pages: 167-178

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Quantitative electroencephalography of medetomidine, medetomidine-midazolam and medetomidine-midazolam-butorphanol in dogs2002

    • Author(s)
      Kazuhito Itamoto
    • Journal Title

      Journal of Veterinary Medicine, Series A 49・4

      Pages: 169-172

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Neurohormonal and metabolic effects of medetomidine compared with xylazine in beagle dogs2002

    • Author(s)
      Tamas Ambrisko
    • Journal Title

      Canadian Journal of Veterinary Research 66(1)

      Pages: 42-49

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cardiopulmonary, hematological, serum biochemical and behavioral effects of sevoflurane compared with isoflurane or halothane in spontaneously ventilating goats2002

    • Author(s)
      Yoshiaki Hikasa
    • Journal Title

      Small Ruminant Research 43(2)

      Pages: 167-178

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Quantitative electroencephalography of medetomidine, medetomidine-midazolam and medetomidine-midazolam-butorphanol in dogs2002

    • Author(s)
      Kazuhito Itamoto
    • Journal Title

      Journal of Veterinary Medicine, Series A 49(4)

      Pages: 169-172

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of imidazoline and non-imidazoline α-adrenergic agents on canine platelet aggregation1999

    • Author(s)
      Yoshiaki Hikasa
    • Journal Title

      Pharmacology 58・4

      Pages: 171-182

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of imidazoline and non-imidazoline α-adrenergic agents on canine platelet aggregation1999

    • Author(s)
      Yoshiaki Hikasa
    • Journal Title

      Pharmacology 58(4)

      Pages: 171-182

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Tamas Ambrisko: "The antagonistic effects of atipamezole and yohimbine on stress-related neurohormonal and metabolic responses induced by medetomidine in dogs"Canadian Journal of Veterinary Research. 67・1. 64-67 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tamas Ambrisko: "Hormonal and metabolic effects of medetomidine and xylazine in dogs."Hungarian Veterinary Journal. 125・4. 219-223 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tamas Ambrisko: "Hormonal and metabolic effects of atipamezole and yohimbine in dogs sedated with medetomidine."Hungarian Veterinary Journal. 125・6. 346-350 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tamas Ambrisko: "Neurohormonal and metabolic effects of medetomidine compared with xylazine in beagle dogs"Canadian Journal of Veterinary Research. 66・1. 42-49 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kazuhito Itamoto: "Quantitative electroencephalography of medetomidine, medetomidine-midazolam and medetomidine-midazolam-butorphanol in dogs"Journal of Veterinary Medicine, Series A. 49. 169-172 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshiaki Hikasa: "Cardiopulmonary hematological serum biochemcal and behavioural effects of sevoflurane compared with isoflurane or haolthane in spontaneously ventilating goats"Small Ruminant Research. 43. 167-178 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tamas Ambrisko: "The antagonistic effects of atipamezole and yohimbine on stress-related neurohormonal and metabolic responses induced by medetomidine in dogs"Canadian Journal of Veterinary Research. 67. 64-67 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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