| Project/Area Number |
14570058
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | OSAKA UNIVERSITY |
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Principal Investigator |
NAGASHIMA Kei Osaka University, School of Medicine, Assistant Prof., 医学系研究科, 助手 (40275194)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2003: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2002: ¥3,000,000 (Direct Cost: ¥3,000,000)
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| Keywords | body temperature / metabolism / circadian rhythm / Vagus nerve / SCN / heat loss / homeostasis / food deprivation / 迷走神経 / 生物時計 / 体温 / 低体温 / 熱産生 / 尾部血流 |
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| Research Abstract |
It is well known that body temperature (T_b) follows a circadian rhythm. Despite recent advance in knowledge of thermoregulation, we know only a little about the mechanism of the T_b rhythm. In this symposium, we show several evidences proving that i) the prime mechanism for the circadian T_b rhythm is a change in characteristics of thermoregulatory processes according to circadian phases, ii) clock genes and the suprachiasmatic nucleus are involved in the mechanism.
T_b rhythm during fasting. In ad-lib feeding rats, T_b rhythm was linked with heat production rhythm. Moreover, tail surface temperature reflecting active heat loss also changed linearly with the T_b rhythm. Thus it is thought that heat production dominantly determines the T_b rhythm in fed condition. Although heat production decreased and its circadian amplitude was blunted during 3-day fasting, the T_b rhythm was well maintained. Moreover, the tail temperature decreased greatly in the active phase. These results suggest that animals control their circadian T_b rhythm by modulating thermoregulatory responses, which depends on feeding and/or nutritional states.
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