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Neural mechanisms controlling food intake during stress

Research Project

Project/Area Number 14570068
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionJichi Medical School

Principal Investigator

ONAKA Tatsushi  Jichi Medical School, Physiology, Associate Professor, 医学部, 助教授 (90177254)

Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordsstress / conditioned fear / noxious stimuli / oxytocin / noradrenaline / PrRP / orexin / food intake / Fos
Research Abstract

Stressful stimuli increase or decrease food intake dependent upon the stimuli applied. Neural mechanisms underling this stress-induced modulation of food intake remain to be clarified. Firstly, we attempted to make up a new instrument for measuring food intake automatically. By using this instrument, we have found that noxious stimuli with relatively weak intensity increase food intake, while emotional stimuli (immobilization stress) decrease food intake. In order to investigate neural pathways involved in stress-induced modulation, we performed a retrograde tracing study combined with Fos immunohistochemical detection. Noxious stimuli that are orexigenic stimuli activated orexin neurones in the lateral hypothalamus, which have facilitative effects upon food intake. On the other hand, anorexigenic stressful stimuli (conditioned fear stimuli) activated A2 noradrenergic neurones in the dorsomedial medulla oblongata, which contain an anorexic peptide, PrRP. Blocking of endogenous PrRP by application of anti-PrRP antibodies increased basal food intake and fasting-induced food intake, and reduced the stress-induced decrease in food intake. All these data suggest that noxious stimuli induce food intake via activation of orexin neurones, while emotional stimuli reduce food intake via activation of PrRP neurones.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] Onaka T, Ikeda K, Yamashita T, Honda K.: "Facilitative role of endogenous oxytocin in noradrenaline release in the rat supraoptic nucleus"Eur J Neurosci. 18. 3018-3026 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Rokkaku K, Onaka T, Okada N, Ideno J, Kawakami A, Honda K, Yada T, Ishibashi S.: "Neuromedin U facilitates oxytocin release from the pituitary via β adrenoceptors."Neuroreport. 14. 1997-2000 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Onaka T, Serino R, Ueta Y.: "Intermittent footshock facilitates dendritic vasopressin release but suppresses vasopressin synthesis within the rat supraoptic nucleus."J Neuroendocrinol. 15. 629-632 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hada T, Onaka T, Takahashi T, Hiraga A, Yagi K.: "Effects of novelty stress on neuroendocrine activities and running performance in Thoroughbred horses."J Neuroendocrinol. 15. 638-648 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zhu LL, Onaka T.: "Facilitative role of prolactin-releasing peptide neurons in oxytocin cell activation after conditioned fear stimuli."Neuroscience. 118. 1045-1053 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zhu LL, Onaka T.: "Involvement of medullary A2 noradrenergic neurons in the activation of oxytocin neurons after conditioned fear stimuli"Eur J Neurosci. 16. 2186-2198 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ueta Y, Ozaki Y, Saito Y, Onaka T.: "Involvement of novel feeding-related peptides in neuroendocrine response to stress."Exp Biol Med (Maywood). 228. 1168-1174 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Onaka T.: "Neural pathways controlling central and peripheral oxytocin release from the pituitary during stress."J Neuroendocrinol. 16. 308-312 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ozaki Y, Onaka T, Nakazato M, Saito J, Kanemoto K, Matsumoto T, Ueta Y.: "Centrally administered Neuromedin U activates neurosecretion with induction of c-fos mRNA in the paraventricular and supraoptic nuclei of rat."Endocrinology. 143. 4320-4329 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zhu LL, Onaka T, Sakurai T, Yada T.: "Activation of orexin neurones after noxious but not conditioned fear stimuli in rats"Neuroreport. 13. 1351-1353 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Onaka T, Ikeda K, Yamashita T, Honda K.: "Facilitative role of endogenous oxytocin in noradrenaline release in the rat supraoptic nucleus."Eur J Neurosci. 18. 3018-3026 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Rokkaku K, Onaka T, Okada N, Ideno J, Kawakami A, Honda K, Yada T, Ishibashi S.: "Neuromedin U facilitates oxytocin release from the pituitary via β adrenoceptors."Neuroreport. 14. 1997-2000 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Onaka T, Serino R, Ueta Y.: "Intermittent footshock facilitates dendritic vasopressin release but suppresses vasopressin synthesis within the rat supraoptic nucleus."J Neuroendocrinol. 15. 629-632 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hada T, Onaka T, Takahashi T, Hiraga A, Yagi K.: "Effects of novelty stress on neuroendocrine activities and running performance in Thoroughbred horses."J Neuroendocrinol. 15. 638-648 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zhu LL, Onaka T.: "Facilitative role of prolactin-releasing peptide neurons in oxytocin cell activation after conditioned fear stimuli."Neuroscience. 118. 1045-1053 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zhu LL, Onaka T.: "Involvement of medullary A2 noradrenergic neurons in the activation of oxytocin neurons after conditioned fear stimuli"Eur J Neurosci. 16. 2186-2198 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zhu LL, Onaka T, Sakurai T, Yada T.: "Activation of orexin neurones after noxious but not conditioned fear stimuli in rats."Neuroreport. 13. 1351-1353 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ozaki Y, Onaka T, Nakazato M, Saito J, Kanemoto K, Matsumoto T, Ueta Y.: "Centrally administered Neuromedin U activates neurosecretion with induction of c-fos mRNA in the paraventricular and supraoptic nuclei of rat."Endocrinology. 143. 4320-4329 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Onaka T.: "Neural pathways controlling central and peripheral oxytocin release from the pituitary during stress."J Neuroendocrinol. 16. 308-312 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ueta Y, Ozaki Y, Saito Y, Onaka T.: "Involvement of novel feeding-related peptides in neuroendocrine response to stress."Exp Biol Med (Maywood). 228. 1168-1174 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Onaka T, Ikeda K, Yamashita T, Honda K.: "Facilitative role of endogenous oxytocin in noradrenaline release in the rat supraoptic nucleus"Eur J Neurosci. 18. 3018-3026 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Rokkaku K, Onaka_T, Okada N, Ideno J, Kawakami A, Honda K, Yada T, Ishibashi S.: "Neuromedin U facilitates oxytocin release from the pituitary via β adrenoceptors."Neuroreport. 14. 1997-2000 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Onaka_T, Serino R, Ueta Y.: "Intermittent footshock facilitates dendritic vasopressin release but suppresses vasopressin synthesis within the rat supraoptic nucleus."J Neuroendocrinol. 15. 629-632 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ikeda K, Onaka_T, Yamakado M, Nakai J, Ishikawa T, Taketo MM, Kawakami K.: "Degeneration of the amygdala/piriform cortex and enhanced fear/anxiety behaviors in sodium pump α2 subunit (Atplα2) deficient mice."J Neurosci. 23. 4667-4676 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Zhu LL, Onaka_T.: "Facilitative role of prolactin-releasing peptide neurons in oxytocin cell activation after conditioned fear stimuli."Neuroscience. 118. 1045-1053 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Onaka T.: "Neural pathways controlling oxytocin release from the pituitary during stress."J Neuroendocrinol. in press.

    • Related Report
      2003 Annual Research Report
  • [Publications] Ueta Y, Ozaki Y, Saito Y, Onaka_T.: "Involvement of novel feeding-related peptides in neuroendocrine response to stress."Exp Biol Med (Maywood). 228. 1168-1174 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hada T, Onaka_T, Takahashi T, Hiraga A, Yagi K.: "Effects of novelty stress on neuroendocrine activities and running performance in Thoroughbred horses."J Neuroendocrinol. 15. 638-648 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ozaki Y, Onaka T, Nakazato M, Saito J, Kanemoto K, Matsumoto T, Ueta Y.: "Centrally administered Neuromedin U activates neurosecretion with induction of of c-fos mRNA in the paraventricular and supraoptic nuclei of rat"Endocrinology. 143. 4320-4329 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Zhu L, Onaka T, Sakurai T, Yada T.: "Activation of orexin neurones after noxious but not conditioned fear stimuli in rats"NeuroReport. 13. 1351-1353 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Zhu L, Onaka T.: "Involvement of medullary A2 noradrenergic neurons in the activation of oxytocin neurons after conditioned fear stimuli"Eur J Neurosci. 16. 2186-2198 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Zhu L, Onaka T: "Facilitative role of prolactin-releasing peptide neurons in oxytocin cell activation after conditioned fear stimuli"Neuroscience. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ikeda K, Onaka T, Yamakado M, Nakai J, Ishikawa T, Taketo MM, Kawakami K.: "Degeneration of the amygdala/piriform cortex and enhanced fear/anxiety behaviors in sodium pump α2 subunit(Atp1α2)deficient mice"J Neurosci. (in press). (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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