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Identification and functional characterization of all the genes of heterodimeric amino acid transporter family by means of whole genome information

Research Project

Project/Area Number 14570085
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionKyorin University

Principal Investigator

KANAI Yoshikatsu  Kyorin University, School of Medicine, Professor, 医学部, 教授 (60204533)

Co-Investigator(Kenkyū-buntansha) IRIBE Yuji  Kyorin University, School of Medicine, Assistant Professor, 医学部, 助手 (20348618)
KIM Dokyung  Kyorin University, School of Medicine, Assistant Professor, 医学部, 助手 (40327474)
ANZAI Naohiko  Kyorin University, School of Medicine, Assistant Professor, 医学部, 助手 (70276054)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2002: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsAmino acid / transporter / membrane transport / genome / postgenome / SLC / Heterodimeric protein / epithelial transport
Research Abstract

Heterodimeric amino acid transporters are formed by disulfide bonding of a twelve-membrane spanning protein (catalytic subunit) and a single membrane spanning protein (regulatory subunit). We have performed BLAST searches of human and mouse genome data bases using amino acid sequences of LAT1, BAT1 and CAT1 as queries. We have found 5 new genes, SLC7-N1〜5, as new members of SLC7 family. By searching EST (expressed sequence tag) data bases, we have concluded that two of them (SLC7-N4 and SLC7-N5) are pseudogenes, because they never appear in EST data bases. SLC7-N1 possesses 12 transmembrane domains and is supposed to be a catalytic subunit of heterodimeric amino acid transporters. We have named it AGT-1. AGT-1 protein is found on the basolateral membrane of proximal and distal tubules of mouse kidney. Because AGT-1 is supposed to be linked with unknown regulatory subunit, we have generated fusion proteins in which AGT-1 is connected with known regulatory subunits 4F2hc or rBAT and expressed them in Xenopus oocytes. The fusion proteins appear on the plasma membrane and exhibit the transport of acidic amino acids. SLC7-N2 possesses 14 transmembrane domains and exhibits particularly high affinity to arginine, thus we named it CATS (cationic amino acid transporter 5). CATS is expressed in the syncytio-trophoblast of mouse placenta and supposed to mediate transport of amino acids through the placental barrier as well as to supply placental cells with arginine as a precursor of NO synthesis. SLC7-N3 also possesses 14 transmembrane domains and transports small neutral amino acids as well as small basic amino acids, thus we have named it y^+Asc-1. In this study, the function of all the members of heterodimeric amino acid transporter family has been revealed. The results of this study would provide essential information to establish the basis for the genome-wide analyses of diseases or pathological conditions and facilitate drug design targeting the transporters of interest.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (109 results)

All 2005 2004 2003 2002 Other

All Journal Article (71 results) Book (2 results) Publications (36 results)

  • [Journal Article] 近位尿細管輸送機能異常-基礎医学的観点から2005

    • Author(s)
      金井 好克
    • Journal Title

      腎と透析 58(2)

      Pages: 185-189

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] グリア細胞のシスチン-グルタミン酸交換輸送機構と酸化ストレス2005

    • Author(s)
      金井好克
    • Journal Title

      Clinical Neuroscience 23(2)

      Pages: 219-222

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions.2004

    • Author(s)
      Sakata T
    • Journal Title

      Biochem Biophys Res Commun. 313(3)

      Pages: 789-793

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Transport of 99mTc-MAG3 via rat renal organic anion transporter 1.2004

    • Author(s)
      Shikano N
    • Journal Title

      J Nucl Med. 45(1)

      Pages: 80-85

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Expression and functional characterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells.2004

    • Author(s)
      Matsuo H
    • Journal Title

      Cancer Lett. 358(2)

      Pages: 123-126

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Sequential increases in 4F2hc expression during DMBA-induced hamster buccal pouch carcinogenesis.2004

    • Author(s)
      Yoon JH
    • Journal Title

      Anticancer Res. 205(2)

      Pages: 215-226

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Preferential expression of L-type amino acid transporter 1 in ameloblasts during rat tooth development.2004

    • Author(s)
      Park JC
    • Journal Title

      Anat Histol Embryol. 33(2)

      Pages: 119-124

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules.2004

    • Author(s)
      Ekaratanawong S
    • Journal Title

      J Pharmacol Sci. 94(3)

      Pages: 297-304

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Measurement of glutamate uptake and reversed transport by rat synaptosome transporters.2004

    • Author(s)
      Nishida A
    • Journal Title

      Biol Pharm Bull. 27(6)

      Pages: 813-816

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Nicergoline enhances glutamate uptake via glutamate transporters in rat cortical synaptosomes.2004

    • Author(s)
      Nishida A
    • Journal Title

      Biol Pharm Bull. 27(6)

      Pages: 817-820

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Expression of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (4F2hc) in oral squamous cell carcinoma and its precusor lesions.2004

    • Author(s)
      Kim do K
    • Journal Title

      Anticancer Res. 24(3a)

      Pages: 1671-1675

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Lysophosphatidylcholine enhances cytokine production of endothelial cells via induction of L-type amino acid transporter 1 and cell surface antigen 4F2.2004

    • Author(s)
      Takabe W
    • Journal Title

      Arterioscler Thromb Vasc Biol. 24(9)

      Pages: 1640-1645

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Mutations in SLC6A19,encoding B0AT1,cause Hartnup disorder.2004

    • Author(s)
      Kleta R
    • Journal Title

      Nat Genet. 36(9)

      Pages: 999-1002

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus.2004

    • Author(s)
      Anzai N
    • Journal Title

      J Biol Chem. 279(44)

      Pages: 45942-45950

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells.2004

    • Author(s)
      Kim do K
    • Journal Title

      Neurosci Res. 50(4)

      Pages: 437-446

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] CATs and HATs : the SLC7 family of amino acid transporters.2004

    • Author(s)
      Verrey F
    • Journal Title

      Pflugers Arch. 447(5)

      Pages: 532-542

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The ancillary proteins of HATs : SLC3 family of amino acid transporters.2004

    • Author(s)
      Palacin M
    • Journal Title

      Pflugers Arch. 447(5)

      Pages: 490-494

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The glutamate/neutral amino acid transporter family SLC1 : molecular, physiological and pharmacological aspects.2004

    • Author(s)
      Kanai Y
    • Journal Title

      Pflugers Arch. 447(5)

      Pages: 469-479

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 尿酸トランスポーターの分子実体2004

    • Author(s)
      細山田 真
    • Journal Title

      Gout and Nucleic Acid Metabolism 28(1)

      Pages: 1-5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 尿素トランスポーターの分子実体と尿濃縮における役割2004

    • Author(s)
      金井 好克
    • Journal Title

      腎と透析 57(4)

      Pages: 478-482

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions.2004

    • Author(s)
      Sakata T, Anzai N, Shin HJ, Noshiro R, Hirata T, Yokoyama H, Kanai Y, Endou H
    • Journal Title

      Biochem Biophys Res Commun 313(3)

      Pages: 789-793

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Transport of 99mTc-MAG3 via rat renal organic anion transporter 1.2004

    • Author(s)
      Shikano N, Kanai Y, Kawai K, Ishikawa N, Endou H
    • Journal Title

      J Nucl Med 45(1)

      Pages: 80-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] High affinity D- and L-serine transporter Asc-1 : cloning and dendritic localization in the rat cerebral and cerebellar cortices.2004

    • Author(s)
      Matsuo H, Kanai Y, Tokunaga M, Nakata T, Chairoungdua A, Ishimine H, Tsukada S, Ooigawa H, Nawashiro H, Kobayashi Y, Fukuda J, Endou H
    • Journal Title

      Neurosci Lett 358(2)

      Pages: 123-126

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Expression and functional characterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells.2004

    • Author(s)
      Yoon JH, Kim YB, Kim MS, Park JC, Kook JK, Jung HM, Kim SG, Yoo H, Ko YM, Lee SH, Kim BY, Chun HS, Kanai Y, Endou H, Kim do K
    • Journal Title

      Cancer Lett 205(2)

      Pages: 215-226

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Preferential expression of L-type amino acid transporter 1 in ameloblasts during rat tooth development.2004

    • Author(s)
      Park JC, Kim YB, Yoon JH, Kim HJ, Kim SM, Kanai Y, Endou H, Kim DK
    • Journal Title

      Anat Histol Embryol 33(2)

      Pages: 119-124

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules.2004

    • Author(s)
      Ekaratanawong S, Anzai N, Jutabha P, Miyazaki H, Noshiro R, Takeda M, Kanai Y, Sophasan S, Endou H
    • Journal Title

      J Pharmacol Sci 94(3)

      Pages: 297-304

    • NAID

      130000073849

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Measurement of glutamate uptake and reversed transport by rat synaptosome transporters.2004

    • Author(s)
      Nishida A, Iwata H, Kudo Y, Kobayashi T, Matsuoka Y, Kanai Y, Endou H
    • Journal Title

      Biol Pharm Bull 27(6)

      Pages: 813-816

    • NAID

      110003608862

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Nicergoline enhances glutamate uptake via-glutamate transporters in rat cortical synaptosomes.2004

    • Author(s)
      Nishida A, Iwata H, Kudo Y, Kobayashi T, Matsuoka Y, Kanai Y, Endou H
    • Journal Title

      Biol Pharm Bull 27(6)

      Pages: 817-820

    • NAID

      110003608863

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Expression of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (4F2hc) in oral squamous cell carcinoma and its precusor lesions.2004

    • Author(s)
      Kim do K, Ahn SG, Park JC, Kanai Y, Endou H, Yoon JH
    • Journal Title

      Anticancer Res 24(3a)

      Pages: 1671-1675

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Lysophosphatidylcholine enhances cytokine production of endothelial cells via induction of L-type amino acid transporter 1 and cell surface antigen 4F2.2004

    • Author(s)
      Takabe W, Kanai Y, Chairoungdua A, Shibata N, Toi S, Kobayashi M, Kodama T, Noguchi N
    • Journal Title

      Arterioscler Thromb Vasc Biol 24(9)

      Pages: 1640-1645

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Mutations in SLC6A19, encoding BOAT1, cause Hartnup disorder.2004

    • Author(s)
      Kleta R, Romeo E, Ristic Z, Ohura T, Stuart C, Arcos-Burgos M, Dave MH, Wagner CA, Camargo SR, Inoue S, Matsuura N, Helip-Wooley A, Bockenhauer D, Warth R, Bernardini I, Visser G, Eggermann T, Lee P, Chairoungdua A, Jutabha P, Babu E, Nilwarangkoon S, Anzai N, Kanai Y, Verrey F, Gahl WA, Koizumi A
    • Journal Title

      Nat Genet 36(9)

      Pages: 999-1002

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus.2004

    • Author(s)
      Anzai N, Miyazaki H, Noshiro R, Khamdang S, Chairoungdua A, Shin HJ, Enomoto A, Sakamoto S, Hirata T, Tomita K, Kanai Y, Endou H
    • Journal Title

      J Biol Chem 279(44)

      Pages: 45942-45950

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells.2004

    • Author(s)
      Kim do K, Kim IJ, Hwang S, Kook JH, Lee MC, Shin BA, Bae CS, Yoon JH, Ahn SG, Kim SA, Kanai Y, Endou H, Kim JK
    • Journal Title

      Neurosci Res 50(4)

      Pages: 437-446

    • NAID

      10023901883

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] CATs and HATs : the SLC7 family of amino acid transporters.2004

    • Author(s)
      Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y
    • Journal Title

      Pflugers Arch 447(5)

      Pages: 532-542

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The ancillary proteins of HATs : SLC3 family of amino acid transporters.2004

    • Author(s)
      Palacin M, Kanai Y
    • Journal Title

      Pflugers Arch 447(5)

      Pages: 490-494

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The glutamate/neutral amino acid transporter family SLC1 : molecular, physiological and pharmacological aspects.2004

    • Author(s)
      Kanai Y, Hediger MA
    • Journal Title

      Pflugers Arch 447(5)

      Pages: 469-479

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Characterization of 3-[125I]iodo-alpha-methyl-L-tyrosine transport via human L-type amino acid transporter 1.2003

    • Author(s)
      Shikano N
    • Journal Title

      Nucl Med Biol. 30(1)

      Pages: 31-37

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Functional properties of multispecific amino acid transporters and their implications to transporter-mediated toxicity.2003

    • Author(s)
      Kanai Y
    • Journal Title

      Toxicol Sci. 28(1)

      Pages: 1-17

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Isoform selectivity, of 3-125I-iodo-alpha-methyl-L-tyrosine membrane transport in human L-type amino acid transporters.2003

    • Author(s)
      Shikano N
    • Journal Title

      J Nucl Med. 44(2)

      Pages: 244-246

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Initial changes of hepatic glycogen granules and glycogen phosphorylase a after exposure to 7,12-dimethylbenz[a]anthracene in rats.2003

    • Author(s)
      Muto, T
    • Journal Title

      J.Toxicol.Pathol. 16

      Pages: 153-160

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Identification of novel voltage-driven organic anion transporter present at apical membrane of renal proximal tubule.2003

    • Author(s)
      Jutabha P
    • Journal Title

      J Biol Chem. 278(30)

      Pages: 27930-27938

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters.2003

    • Author(s)
      Babu E
    • Journal Title

      J Biol Chem. 278(44)

      Pages: 43838-43845

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Sequential increases in 4F2hc expression during DMBA-induced hamster buccal pouch carcinogenesis.2003

    • Author(s)
      Yoon JH
    • Journal Title

      Anticancer Res. 23(5A)

      Pages: 3877-3881

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The glutamate and neutral amino acid transporter family : physiological and pharmacological implications.2003

    • Author(s)
      Kanai Y
    • Journal Title

      Eur J Pharmacol. 479(1-3)

      Pages: 237-247

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Time course of expression of 7,12-dimethylbenz[a]anthracene-induced CYP1A1 and CYP1B1 mRNA and protein in rat liver.2003

    • Author(s)
      Muto, T
    • Journal Title

      J.Toxicol.Pathol. 16

      Pages: 287-290

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] アミノ酸輸送体の多様性:アミノ酸代謝異常症の分子基盤2003

    • Author(s)
      金井好克
    • Journal Title

      Molecular Medicine 40

      Pages: 782-790

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Characterization of 3-[125I]iodo-alpha-methyl-L-tyrosine transport via human L-type amino acid transporter 1.2003

    • Author(s)
      Shikano N, Kanai Y, Kawai K, Ishikawa N, Endou H
    • Journal Title

      Nucl Med Biol 30(1)

      Pages: 31-37

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Functional properties of multispecific amino acid transporters and their implications to transporter-mediated toxicity.2003

    • Author(s)
      Kanai Y, Endou H
    • Journal Title

      Toxicol Sci 28(1)

      Pages: 1-17

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Isoform selectivity of 3-125I-iodo-alpha-methyl-L-tyrosine membrane transport in human L-type amino acid transporters.2003

    • Author(s)
      Shikano N, Kanai Y, Kawai K, Inatomi J, Kim do K, Ishikawa N, Endou H
    • Journal Title

      J Nucl Med 44(2)

      Pages: 244-246

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Initial changes of hepatic glycogen granules and glycogen phosphorylase a after exposure to 7,12-dimethylbenz[a]anthracene in rats.2003

    • Author(s)
      Muto, T, Takasaki, S, Takahashi, T, Hano, H, Kanai, Y, Wakui, S, Endou, H, Furusato, M
    • Journal Title

      J.Toxicol.Pathol. 16

      Pages: 153-160

    • NAID

      10025850887

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Identification of a novel voltage-driven organic anion transporter present at apical membrane of renal proximal tubule.2003

    • Author(s)
      Jutabha P, Kanai Y, Hosoyamada M, Chairoungdua A, Kim do K, Iribe Y, Babu E, Kim JY, Anzai N, Chatsudthipong V, Endou H
    • Journal Title

      J Biol Chem 278(30)

      Pages: 27930-27938

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters.2003

    • Author(s)
      Babu E, Kanai Y, Chairoungdua A, Kim do K, Iribe Y, Tangtrongsup S, Jutabha P, Li Y, Ahmed N, Sakamoto S, Anzai N, Nagamori S, Endou H
    • Journal Title

      J Biol Chem 278(44)

      Pages: 43838-43845

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Sequential increases in 4F2hc expression during DMBA-induced hamster buccal pouch carcinogenesis.2003

    • Author(s)
      Yoon JH, Kim YB, Kanai Y, Endou H, Kim do K
    • Journal Title

      Anticancer Res 23(5A)

      Pages: 3877-3881

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The glutamate and neutral amino acid transporter family : physiological and pharmacological implications.2003

    • Author(s)
      Kanai Y, Hediger MA
    • Journal Title

      Eur J Pharmacol 479(1-3)

      Pages: 237-247

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Time course of expression of 7,12-dimethylbenz[a]anthracene-induced CYP1A1 and CYP1B1 mRNA and protein in rat liver.2003

    • Author(s)
      Muto, T, Watanabe, T, Moto, M, Okamura, M, Kashida, Y, Kanai, Y, Mitsumori, K, Endou, H
    • Journal Title

      J.Toxicol.Pathol. 16

      Pages: 287-290

    • NAID

      10025851360

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Transport of amino acid-related compounds mediated by L-type amino acid transporter 1(LAT1) : insights into the mechanisms of substrate recognition.2002

    • Author(s)
      Uchino H
    • Journal Title

      Mol Pharmacol. 61(4)

      Pages: 729-737

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains.2002

    • Author(s)
      Matsuo H
    • Journal Title

      J Biol Chem. 277(23)

      Pages: 21017-21026

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Molecular identification of a renal urate anion exchanger that regulates blood urate levels.2002

    • Author(s)
      Enomoto A
    • Journal Title

      Nature 417(6887)

      Pages: 447-452

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment.2002

    • Author(s)
      Hosoya K
    • Journal Title

      J Pharmacol Exp Ther. 302(1)

      Pages: 225-231

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition.2002

    • Author(s)
      Enomoto A
    • Journal Title

      J Biol Chem. 277(39)

      Pages: 36262-26271

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Characterization of the system L amino acid transporter T24 human bladder carcinoma cells.2002

    • Author(s)
      Kim do K
    • Journal Title

      Biochim Biophys Acta. 1565(1)

      Pages: 112-121

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation.2002

    • Author(s)
      Mukobata, S
    • Journal Title

      Biochem.Biophys.Res.Commun. 297

      Pages: 722-728

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] ヘテロ二量体型アミノ酸トランスポーターファミリーの基質認識の機序2002

    • Author(s)
      金井好克
    • Journal Title

      日本応用酵素協会誌 16

      Pages: 9-18

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 多選択性中性アミノ酸トランスポーターLAT1の中枢神経における役割2002

    • Author(s)
      金井好克
    • Journal Title

      脳の科学 24

      Pages: 367-377

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1) : insights into the mechanisms of substrate recognition.2002

    • Author(s)
      Uchino H, Kanai Y, Kim do K, Wempe MF, Chairoungdua A, Morimoto E, Anders MW, Endou H
    • Journal Title

      Mol Pharmacol 61(4)

      Pages: 729-737

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains.2002

    • Author(s)
      Matsuo H, Kanai Y, Kim JY, Chairoungdua A, Kim do K, Inatomi J, Shigeta Y, Ishimine H, Chaekuntode S, Tachampa K, Choi HW, Babu E, Fukuda J, Endou H
    • Journal Title

      J Biol Chem 277(23)

      Pages: 21017-21026

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Molecular identification of a renal urate anion exchanger that regulates blood urate levels.2002

    • Author(s)
      Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, Matsuo H, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata K, Niwa T, Kanai Y, Endou H
    • Journal Title

      Nature 417(6887)

      Pages: 447-452

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment.2002

    • Author(s)
      Hosoya K, Tomi M, Ohtsuki S, Takanaga H, Saeki S, Kanai Y, Endou H, Naito M, Tsuruo T, Terasaki T
    • Journal Title

      J Pharmacol Exp Ther 302(1)

      Pages: 225-231

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition.2002

    • Author(s)
      Enomoto A, Wempe MF, Tsuchida H, Shin HJ, Cha SH, Anzai N, Goto A, Sakamoto A, Niwa T, Kanai Y, Anders MW, Endou H
    • Journal Title

      J Biol Chem 277(39)

      Pages: 36262-36271

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells.2002

    • Author(s)
      Kim do K, Kanai Y, Choi HW, Tangtrongsup S, Chairoungdua A, Babu E, Tachampa K, Anzai N, Iribe Y, Endou H
    • Journal Title

      Biochim Biophys Acta 1565(1)

      Pages: 112-121

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation.2002

    • Author(s)
      Mukobata, S, Hibino, T, Sugiyama, A, Urano, Y, Inatomi, A, Kanai, Y, Endo, H, Tashiro F
    • Journal Title

      Biochem.Biophys.Res.Commun. 297

      Pages: 722-728

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Book] シスチン尿症、先端医療シリーズ31腎臓病-診断と治療の最前線(浅野泰、下条文武、秋澤忠男編)2004

    • Author(s)
      金井 好克
    • Total Pages
      6
    • Publisher
      先端医療技術研究所
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Book] アミノ酸代謝、腎臓ナビゲーター(浦信行、柏原直樹、熊谷裕生、竹内和久編)2004

    • Author(s)
      金井 好克
    • Total Pages
      2
    • Publisher
      メディカルレビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shikano, N, Kanai, Y, Kawai, K, Ishikawa, N, Endou, H.: "Characterization of 3-[(125)I]iodo-alpha-methyl-L-tyrosine transport via human L-type amino acid transporter 1."Nucl.Med.Biol.. 30. 31-37 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shikano, N, Kanai, Y, Kawai, K, Inatomi, J, Kim, DK, Ishikawa, N, Endou: "Isoform selectivity of 3-125I-iodo-alpha-methyl-L-tyrosine membrane transport in human L-type amino acid transporters."J.Nucl.Med.. 44. 244-246 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Muto, T, Takasaki, S, Takahashi, T, Hano, H, Kanai, Y, Wakui, S, Endou, H, Furusato, M: "Initial changes of hepatic glycogen granules and glycogen phosphorylase a after exposure to 7,12-dimethylbenz[a]anthracene in rats."J.Toxicol.Pathol.. 16. 153-160 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Jutabha, P, Kanai, Y, Hosoyamada, M, Chairoungdua, A, Kim, DK, Iribe, Y, Babu, E, Kim, JY, Anzai, N, Chatsudthipong, V, Endou, H: "Identification of a novel voltage-driven organic anion transporter present at apical membrane of renal proximal tubule."J.Biol.Chem.. 278. 27930-27938 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Babu, E, Kanai, Y, Chairoungdua, A, Ki, DK, Iribe, Y, Tangtrongsup, S, Jutabha, P, Li, Y, Ahmed, N, Sakamoto, S, Anzai, N, Endou, H: "Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters."J.Biol.Chem.. 278. 43838-43845 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoon, JH, Kim, YB, Kanai, Y, Endou, H, Kim, DK: "Sequential increases in 4F2hc expression during DMBA-induced hamster buccal pouch carcinogenesis."Anticancer Res.. 28. 1-17 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Muto, T, Watanabe, T, Moto, M, Okamura, M, Kashida, Y, Kanai, Y, Mitsumori, K, Endou, H: "Time course of expression of 7,12-dimethylbenz[a]anthracene-induced CYP1A1 and CYP1B1 mRNA and protein in rat liver."J.Toxicol.Pathol.. 16. 287-290 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sakata, T, Anzai, N, Shin, HJ, Noshiro, R, Hirata, T, Yokoyama, H, Kanai, Y, Endou, H: "Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions."Biochem.Biophys.Res.Commun.. 313. 789-793 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shikano N, Kanai Y, Kawai K, Ishikawa N, Endou H: "Transport of 99mTc-MAG3 via rat renal organic anion transporter 1."J Nucl Med.. 45. 80-85 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsuo, H, Kanai, Y, Tokunaga, M, Nakata, T, Chairoungdua, A, Ishimine, H, Tsukada, S, Ooigawa, H, Nawashiro, H, Kobayashi, Y, Fukuda, J, Endou, H: "High affinity D- and L-serine transporter Asc-1 : Cloning and dendritic localization in the rat cerebral and cerebellar cortices."Neurosci.Lett.. 358(2). 123-126 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoon JH, Kim YB, Kim MS, Park JC, Kook JK, Jung HM, Kim SG, Yoo H, Ko YM, Lee SH, Kim BY, Chun HS, Kanai Y, Endou H, Kim do K.: "Expression and functional characterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells."Cancer Lett.. 205. 215-226 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Park JC, Kim YB, Yoon JH, Kim HJ, Kim SM, Kanai Y, Endou H, Kim DK.: "Preferential Expression of L-type Amino Acid Transporter 1 in Ameloblasts During Rat Tooth Development."Anat Histol Embryol.. 33. 119-124 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ekaratanawong S, Anzai N, Jutabha P, Miyazaki H, Noshiro R, Takeda M, Kanai Y, Sophasan S, Endou H: "Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules."J.Pharniacol.Sci.. 94. 297-304 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kanai, Y, Endou, H: "Functional properties of multispecific amino acid transporters and their implications to transporter-mediated toxicity."J.Toxicol.Sci.. 28. 1-17 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 金井好克: "アミノ酸輸送体の多様性:アミノ酸代謝異常症の分子基盤"Molecular Medicine. 40. 782-790 (2003)

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      2003 Annual Research Report
  • [Publications] Verrey, F, Closs, EI, Wagner, CA, Palacin, M, Endou, H, Kanai, Y: "CATs and HATs : the SLC7 family of amino acid transporters."Pflugers Arch.. 447. 532-542 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Palacin, M, Kanai, Y: "The ancillary proteins of HATs : SLC3 family of amino acid transporters."Pflugers Arch.. 447. 490-494 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kanai, Y, Heidiger, MA: "The Glutamate and Neutral Amino Acid Transporter Family : Physiological and Pharmacological Implications."Pflugers Arch.. 447. 469-479 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kanai, Y, Heidiger, MA: "The glutamate and neutral amino acid transporter family : physiological and pharmacological implications."Eur.J.Pharmacol.. 479. 237-247 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kanai Y, Endou H: "Molecular characteristics and physiological and pharmacological implications of heterodimeric amino acid transporters. In Topics in Current Genetics : Molecular Mechanisms Controlling Transmembrane Transport. ed. Stefan Hohmann"Springer, Heidelberg(in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Kim, DK et al.: "The human T-type amino acid transporter 1 : characterization, gene organization and chromosomal location"Genomics. 79. 95-103 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Uchino, H et al.: "Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1):Insights into the mechanisms of substrate recognition"Mol. Pharmacol.. 61. 729-737 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsuo, H et al.: "Identification of a novel Na^+-independent acidic amino acid transporter with structural similarity to the member of heterodimeric amino acid transporter"J. Biol. Chem.. 277. 21017-21026 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Enomoto, A et al.: "Molecular identification of a renal urate-anion exchanger that regulates blood urate levels"Nature. 417. 447-452 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hosoya, K et al.: "Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment"J. Pharmacol. Exp. Ther.. 302. 225-231 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Enomoto, A et al.: "Molecular identification of a novel carnitine transporter specific to human testis : Insights into the mechanism of carnitine recognition"J. Bid. Chem.. 277. 36262-36271 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kim, DK et al.: "Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells"Biochim. Biophys. Acta. 1565. 112-122 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mukobata, S et al.: "M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation"Biochem. Biophys. Res. Commun.. 297. 722-728 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shikano, N et al.: "Characterization of 3-[(125)I] iodo-alpha-methyl-L-tyrosine transport via human L-type amino acid transporter 1"Nuci. Med. Biol.. 30. 31-37 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shikano, N et al.: "Isoform selectivity of 3-125I-iodo-alpha-methyl-L-tyrosine membrane transport in human L-type amino acid transporters"J. Nucl. Med.. 44. 244-246 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kanai, Y et al.: "Functional properties of multispecific amino acid transporters and their imoplications to transporter-mediated toxicity"J. Toxicol. Sci.. 28. 1-17 (2003)

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      2002 Annual Research Report
  • [Publications] Nawashiro, H et al.: "The role of CD98 in astrocytic neoplasms"Hum. Cell. 15. 25-31 (2002)

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  • [Publications] 金井好克: "腎尿細管における糖輸送の分子機構"日本臨床. 60増刊号. 141-150 (2002)

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  • [Publications] 金井好克: "多選択性中性アミノ酸トランスポーターLAT1の中枢神経における役割"脳の科学. 24. 367-377 (2002)

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      2002 Annual Research Report
  • [Publications] Kanai, Y et al.: "The high-affinity glutamate neutral amino-acid transporter family : structure, function, and physiological relevance. In "Neurotransmitter transporters : Structure, function and regulation, 2nd ed.""M.E.A.Reith, Ed., Humana Press, Totowa, N.J.. 255-311 (2002)

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  • [Publications] 金井好克: "中性アミノ酸トランスポーター-その分子実体と中枢神経における役割、シリーズ・バイオサイエンスの新世紀:第12巻「感覚器官と脳内情報処理」"御子柴克彦、清水孝雄編、共立出版. 92-99 (2002)

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Published: 2002-04-01   Modified: 2016-04-21  

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