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Molecular Pathological Study on the dynamics of Ghrelin in patients with gastric diseases

Research Project

Project/Area Number 14570151
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionNagasaki University

Principal Investigator

SEKINE Ichiro  Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (60039922)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Toshiyuki  Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 講師 (30284673)
NAKASHIMA Masahiro  Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 講師 (50284683)
YAMASHITA Shunichi  Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (30200679)
TAKAMURA Noboru  Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 助教授 (30295068)
OHTSURU Akira  Nagasaki University, Graduate School of Biomedical Sciences, Professor, 医学部・歯学部附属病院, 助教授 (00233198)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsGhrelin / Gastric cancer / Leptin / Growth Hormone / IGF-1 / 胃がん
Research Abstract

Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor. It is synthesized predominantly in the stomach and stimulates the hypothalamic appetite center. We tested whether plasma ghrelin levels after gastrectomy were correlated with the percentage postoperative reduction in body mass index (BMI). We measured BMI and morning plasma ghrelin levels after overnight fasting, in patients more than 2 months after distal or total gastrectomy due to gastric cancer, as well as after pancreatico-duodenectomy due to pancreatic cancer or common bile duct cancer. We studied 53 patients, aged 38 to 89 years (average 67 years). The percentage reduction in BMI was calculated from the difference between the present and stable BMI (more than 6 month after operation) and the BMI before operation. We also measured plasma leptin as well as ghrelin. We were able to measure plasma ghrelin levels before and after operation in fourteen cases. Comparison of % BMI reductions and plasma ghrelin levels revealed a significant correlation among the patients undergoing gastrectomy. In contrast, no correlation and noo reduction in ghrelin levels were found in cases of pancreatico-duodenectomy, even though BMI decreased more than in cases of gastrectomy. In addition, plasma ghrelin levels declined more after total gastrectomy than after distal gastrectomy, in agreement with the fact that ghrelin-producing endocrine cells are located in the area of the gastric fundic gland. These results lend support to the hypothesis that post-gastrectomy weight loss is partly explained by ghrelin deficiency as well by defective nutrient absorption. In future, treatment with ghrelin or ghrelin agonists may counteract weight loss and other post-gastrectomy symptoms.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Iwata K, Takamura N, Sekine I他: "Loss of heterozygosity on chromosome 9q22.3 in microdissected basal cell carcinoma around Semipalatinsk nuclear testing site, Kazakhstan."Human Pathology. 印刷中.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Wen C, Nakayama T, Nakashima M他: "Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing"J Gastroenterol. 38・5. 431-435 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakashima M, Nakayama T, Ohtsuru A他: "Expression of Parathyroid Hormone (PTH) - related Peptide (PTHrP) and PTH/PTHrP Receptor in Osteoclast-like Giant Cells"Pathol.Res.Pract. 199・2. 85-92 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Meirmanov S, Nakashima M他: "Small Cell Carcinoma of the Endometrium : Report of a Case with Analysis of Wnt/β-Catenin Pathway"Pathol Res Pract. 199・8. 551-558 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Podchenko A, Ohtsuru A, Tsuda S他: "The Selective Thyrosine Kinase Inhibitor, ST571,Inhibits Growth of Anaplastic Thyroid Cancer Cells"J Clin Endoclinol Metab. 88・4. 1889-1896 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishiguchi M, Takamura N, Aoyagi T他: "Comparison of Ximelagatran with Warfarin for the Prevention of Venous Thromboembolism after Total Knee Replacement"N Engl J Med. 350・6. 616-617 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Iwata K, et al.: "Loss of heterozygosity on chromosome 9q22.3 in microdissected basal cell carcinoma around Semipalatins k nuclear testing site, Kazakhstan"Human Pathology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Wen C et al.: "Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing"J Gastroenterol. 38(5). 431-435 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakashima M et al.: "Expression of Parathyroid Hormone (PTH) -related Peptide (PTHrP) and PTH/PTHrP Receptor in Osteoc last-like Giant Cells"Pathol Res Pract. 199(2). 85-92 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Meirmabnov et al.: "Small Cell Carcinoma of the Endometrium : Report of a Case with Analysis of Wnt/β-Catenin Pathway"J Clin Endocrinol Metab. 199(8). 551-558 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Podchenko T et al.: "The Selective Thyrosine Kinase Inhibitor, ST571, Inhibits Growth of Anaplastic Thyroid Cancer Cells"J Clin Endocrinol Metab. 88(4). 1889-1896 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishiguchi M et al.: "GF-I enhances TGF-beta-induced extracellular matrix protein production through the p38/ATF-2 signaling pathway in keloid fibroblasts"N Engl.J Med. 350(6). 616-617 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Iwata K, Takamura N, Sekine I他: "Loss of heterozygosity on chromosome 9q22.3 in microdissected basal cell carcinoma around Semipalatinsk nuclear testing site, Kazakhstan"Human Pathology. 印刷中.

    • Related Report
      2003 Annual Research Report
  • [Publications] Wen C, Nakayama T, Nakashima M他: "Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing"I Gastroenterol. 38・5. 431-435 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakashima M, Nakayama T, Ohtsuru A他: "Expression of Parathyroid Hormone (PTH) - related Peptide (PTHrP) and PTH/PTHrP Receptor in Osteoclast-like Giant Cells"Pathol.Res.Pract. 199・2. 85-92 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Meirmanov S, Nakashima M他: "Small Cell Carcinoma of the Endometrium : Report of a Case with Analysis of Wnt/β-Catenin Pathway"Pathol Res Pract. 199・8. 551-558 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Daian T, Ohtsuru A, Yamashita S他: "IGF-I enhances TGF-beta-induced extracellular matrix protein production through the p38/ATF-2 signaling pathway in keloid fibroblasts"J Inv Dermatol. 120・6. 956-962 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nishiguchi M, Takamura N, Aoyagi T他: "Comparison of Ximelagatran with Warfarin for the Prevention of Venous Thromboembolism after Total Knee Replacement"N Engl J Med. 350・6. 616-617 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Wen CY, Nakashima M, Nakayama T, Sekine I et al.: "Overexpression of Heat Shock Protein 70 in the Stomach of Stress-Induced Gastric Ulcer-Resistant Soontaneously Hypertensive Rats"Clin Exp Hypertension. 24・6. 448-449 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shichijo K, Ihara M, Sekine I et al.: "Overexpression of Heat Shock Protein 70 in the Stomach of Stress-Induced Gastric Ulcer-Resistant Spontaneously Hypertensive Rats"Clin Exp Hypertension. 24・6. 448-449 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ito M, Nakashima M, Nakayama, Ohtsuru A, Sekine I et al.: "Preventive effects of parathyroid hormone-related peptide on gastric hypercontraction in the rat"Gastroenterol Hepatol. 17・12. 1260-1266 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tsuda S, Ohtsuru A, Yamashita S et al.: "Role of c-Fyn in FGF-2-mediated tube-like structure formation by murine brain capillary endothelial cells"Biochem Biophys Res Commun. 290・4. 1354-1360 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Akiyama-Uchida Y, Ashizawa N, Ohtsuru A et al.: "Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts"Hypertension. 40・2. 148-154 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ito M, Nakashima M, Nakayama T et al.: "Expression of receptor-type tyrosine kinase, axl, and its ligand, gas6, in pediatric thyroid carcinomas around chernobyl"Thyroid. 12・11. 971-975 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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