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Early detection of colonic cancer by histologic and genetic analysis of thyroid tissue

Research Project

Project/Area Number 14570163
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionKEIO UNIVERSITY

Principal Investigator

KAMEYAMA Kaori  Keio University, School of Medicine, Assistant Professor, 医学部, 専任講師 (10245467)

Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsFamilial adenomatous polynosis / Thyroid tumor / cribriform-morular variant / APC gene / microfilament / 大腸癌 / APC遺伝子
Research Abstract

In 1994, Harach et al. histologically reviewed four cases of familial adenomatous polyposis (FAP)-associated thyroid cancer, and identified a distinctive morphology with unusual papillary carcinomas. The tumors had some features of papillary carcinoma, but also exhibited a cribriform pattern and solid areas with a spindle cell component. The authors concluded that this distinct histological picture should alert pathologists to screen such patients and their families far FAP. On the other hand, our group previously, in 1992, reported four unusual papillary thyroid carcinoma cases with peculiar nuclear clearings composed of microfilaments. It is now apparent that our reported cases are histologically identical to the cases described by Harach et al. Over one hundred cases of FAP-associated thyroid carcinoma have reported to date. Most showed the distinct histology that Harach et al. and our group have described. However, some thyroid cancers in non-FAP patients have shown this distinct morphology. Cameselle-Teijeiro et al. proposed naming this tumor the cribriform-morular variant of papillary carcinoma.
We performed ultrastructural and genetic studies of three patients with this type of carcinoma associated FAP. There were numerous microfilaments approximately 100 nm long, at the nuclear clearing area of the morular regions. Some patients showed germline APC mutations, and also had a somatic APC mutation. Both mutations were in previously unreported regions. Our study provides new information for understanding the development of this rare tumor.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Kaori Kameyama: "Cribriform-morular variant of papillary thyroid carcinoma : ultrastructural study and somatic/germline mutation analysis of the APC gene."Ultrastructural Pathology. 28. 97-102 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kaori Kameyama: "Thyroid cancer in familial adenomatous polyposis ; a report of 14 cases."Internal Medicine (Pisa). 10. 217-221 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kaori Kameyama: "FAP associated carcinoma in mother and her daughter."Familial Cancer. 1. 83-86 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kaori Kameyama, et al.: "Cribriform-morular variant of papillary thyroid carcinoma : ultrastructural study and somatic/germline mutation analysis of the APC gene."Ultrastructural Pathology. 28(2). 97-102 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kaori Kameyama, et al.: "Thyroid cancer in familial adenomatous polyposis ; a report of 14 cases."Intarnal Medicine (Pisa). 10(1). 217-221 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kaori Kameyama, et al.: "FAP associated carcinoma in mother and her daughter."Familial Cancer. 1(2). 83-86 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kaori Kameyama: "Cribriform-morular variant of papillary thyroid carcinoma : ultrastructural study and somatic/germline mutation analysis of the APC gene."Ultrastructural Pathology. 28(2)(In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kaori Kameyama: "Thyroid cancer in familial adenomatous polyposis ; a report of 14 cases."Internal Medicine (Pisa). 10(1). 217-221 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kameyama K: "FAP associated carcinoma in mother and her daughter"Familial Cancer. 1・2. 83-86 (2001)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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