| Project/Area Number |
14570232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | KANAZAWA MEDICAL UNIVERSITY (2003)
The University of Tokyo (2002) |
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Principal Investigator |
TAKAHASHI Takashi KANAZAWA MEDICAL UNIVERSITY, Department of Medicine, Lecturer, 医学部, 講師 (00292855)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Pneumocvstis carinii / Sulfa drugs / Drug-resistance / Resistant gene mutations |
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| Research Abstract |
We examined ammo acid mutations in dihydrofolate reductase (DHFR) of Pneumocystis carinii (Pc) isolated from 34 patients with Pc pneumonia in Japan. DHFR mutations (Ala67Val, Cys166Tyr) were observed in the two different patients. However, they were successfully treated with trimethoprim-sulfamethoxazole.
Pc or Cryptococcus neoformans (Cn) carriage was determined in 78 immunocompromised subjects with or without human immunodeficiency virus. Pc colonization in the respiratory tract was round for this population, while no patients colonized with Cn were experienced.
We started cohort study including HIV patients in Thailand (Lampang Provincial Hospital) in August 2003. Amino acid substitutions of the drug-target enzymes in the Pc will be analyzed with the samples of sputum induction.
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