| Project/Area Number |
14570241
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
ISOGAI Hiroshi Sapporo Medical University, School of Medicine, Associated Professor, 医学部, 助教授 (50137436)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2002: ¥2,900,000 (Direct Cost: ¥2,900,000)
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| Keywords | Brn 3b / Behcet' disease / 網膜 / Brn3b / 遺伝子 / 自己傷害作用 / Bes1 / 組換DNA / HSP / S.sanguis / 合成ペプチド / TGマウス / ブドウ膜炎 / S. sanguis |
|---|
| Research Abstract |
About 1kb of Brn 3b DNA was obtained PCR from cDNA library of human embryonic brain. The product was inserted into Escherichia coli and the bacteria produced Brn 3b protein. The bacteria strain was agglutinated by anti-serum to synthetic peptide of Brn 3b. Furthermore, several sera from the patients with BD agglutinated this strain. The results suggested that the Brn 3b protein was correlated with the Behcet's disease.
Now, it is the final stage for developing TG mice which were inserted this DNA.
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