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Induction Mechanisms of Memory T Cells

Research Project

Project/Area Number 14570276
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionChiba University

Principal Investigator

TOKUHISA Takeshi  Chiba University, Graduate School of Medicine, Professor, 大学院・医学研究院, 教授 (20134364)

Co-Investigator(Kenkyū-buntansha) SAKAMOTO Akemi  Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (90359597)
ARIMA Masafumi  Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (00202763)
HATANO Masahiko  Chiba University, Gene Research Center, Associate Professor, 遺伝子実験施設, 助教授 (20208523)
岡田 誠治  熊本大学, エイズ学研究センター, 教授 (50282455)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsMemory T cells / Transcription factor / BCL6 / Transgenic mice / Homeostatic proliferation / Central memory T cells / BAZF / CD8 T cells / CD8T細胞 / 好酸球性アレルギー / IL-5 / 転写抑制 / エフェクター細胞
Research Abstract

Naive T cells proliferate and differentiate into memory cells after antigenic stimulation or in a lymphopenic environment. We showed here transient increases in memory phenotype CD8^+ T cell numbers in the lymphopenic environment of spleens of very young mice. The magnitude of the increase correlated with Bcl-6 expression in the T cells. Bcl-6 controlled the generation and maintenance of antigen-specific memory phenotype CD8^+ T cells in the spleens of immunized mice. These data suggest that Bcl-6, which is also essential for memory B cell development in germinal centers, is a key molecule for the establishment not only of memory T cells but also of the peripheral T cell compartment in infancy.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Honda, K., et al.: "Prostaglandin D2 Reinforces Th2 Type Inflammatory Responses of Airways to Low-dose Antigen through Bronchial Expression of Macrophage-derived Chemokine."J.Exp.Med.. 198. 533-543 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takenaga, M., et al.: "Bcl6-dependent transcriptional repression by BAZF."Biochem.Biophys.Res.Commun.. 303. 600-608 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeda, N., et al.: "Bcl6 is a transcriptional repressor for the IL-18 gene."J.Immunol.. 171. 426-431 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ichii, H., et al.: "Role for Bcl-6 in the generation and maintenance of memory CD8^+ T cells."Nature Immunol.. 3. 558-563 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Toyama, H., et al.: "Memory B cells without somatic hypermutation are generateded from Bcl6-deficient B cells."Immunity. 17. 329-339 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Arima, M., et al.: "A putative silencer element in the IL-S gene recognized by Bcl6."J.Immunol.. 169. 829-836 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Honda, K., et al.: "Prostaglandin D2 Reinforces The Type Inflammatory Responses of Airways to Low-dose Antigen through Bronchial Expression of Macrophage-derived Chemokine."J.Exp.Med. 198. 533-543 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeda, N., et al.: "Bc16 is a transcriptional repressor for the IL-18 gene."J.Immunol.. 171. 426-431 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Toyama, H., et al.: "Memory B cells without somatic hypermutation are generateded from Bcl6-deficient B cells."Immunity. 17. 329-339 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Arima, M., et al.: "A putative silencer element in the IL-S gene recognized by Bcl6."J.Immunol.. 169. 829-836 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ichii, H., et al.: "Role for Bcl-6 in the generation and maintenance of memory CD8^+ T cells."Nature Immunol.. 3. 558-563 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sata, M., et al.: "Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis."Nature Med.. 8. 403-409 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yoshida, T., et al.: "Activation of STAT3 by the Hepatitis C virus core protein leads to cellular transformation."J.Exp.Med.. 196. 641-653 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tada, Y., et al.: "A novel role for Fas ligand in facilitating antigen acquisition by dendritic cells."J.Immunol.. 169. 2241-2245 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murasawa, M., et al.: "GL7 defines the cycling stage of pre-B cells in murine bone marrow."Eur.J.Immunol.. 32. 291-298 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sasagawa, K., et al.: "Identification of Nd1, a novel murine ketch family protein, involved in stabilization of actin filaments."J.Biol.Chem.. 277. 44140-44146 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Bahar, R., et al.: "Growth retardation, polyploidy and multinucleation induced by Clast3, a novel cell cycle-regulated protein."J.Biol.Chem.. 277. 40012-40019 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Obata, S., et al.: "Overexpression of the c-fos gene perturbs functional maturation of Ml cells into macrophages."Mol.Immunol.. 39. 585-594 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takenaga, M., et al.: "Bcl6-dependent transcriptional repression by BAZF."Biochem.Biophys.Res.Commun.. 303. 600-608 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takeda, N., et al.: "Bcl6 is a transcriptional repressor for the IL-18 gene"J.Immunol.. 171. 426-431 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Okada, S., et al.: "Dominant negative effect of the c-fos family gene products on inducibte nitric oxide synthase expression in macrophages."Int.Immunol.. 15. 1275-1282 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Honda, K., et al.: "Prostaglandin D2 Reinforces Th2 Type Inflammatory Responses of Airways to Low-dose Antigen through Bronchial Expression of Macrophage-derived Chemokine."J.Exp.Med.. 198. 533-543 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kawamura, K., et al.: "DNA polymerase θ is preferentially expressed in lymphoid tissues and pregulated in human cancers."Int.J.Cancer. 109. 9-16 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ichii, H., et al.: "Role for Bcl-6 in the generation and maintenance of memory CD8^+T cells"Nature Immunol.. 3. 558-563 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Toyama, H., et al.: "Memory B cells without somatic hypermutation are generateded from Bcl6-deficient B cells"Immunity. 17. 329-339 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sata, M., et al.: "Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis"Nature Med.. 8. 403-409 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshida, T., et al.: "Activation of STAT3 by the Hepatitis C virus core protein leads to cellular transformation"J. Exp. Med.. 196. 641-653 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Arima, M., et al.: "A putative silencer element in the IL-5 gene recognized by Bcl6"J. Immunol.. 169. 829-836 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sasagawa, K., et al.: "Identification of Nd1, a novel murine kelch family protein, involved in stabilization of actin filaments"J. Biol. Chem.. 277. 44140-44146 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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