| Project/Area Number |
14570295
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
ITOH Toshihiro Asahikawa Medical College, Assistant Professor, 医学部, 講師 (20271760)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Hiroshi Tohoku University, Professor, 大学院・医学系研究科, 教授 (40125571)
NAKAGI Yoshihiko Asahikawa Medical College, Assistant, 医学部, 助手 (90322908)
YOSHIDA Takahiko Asahikawa Medical College, Professor, 医学部, 教授 (90200998)
YAMAUCHI Hiroshi St.Marianna University School of Medicine, Assistant Professor, 医学部, 助教授 (90081661)
WATANABE Chiho Tohoku University, Assistant Professor, 大学院・医学系研究科, 助教授 (70220902)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2003: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Inorganic arsenic / behavior / Drinking water / development / Trivalent arsenite / Pentavalent arsenate |
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| Research Abstract |
We investigated the effect of arsenic exposure from the before embryonic on the development of central nervous system of the child. C57B1/6 mouse were exposed trivalent arsenite(As (III)) and pentavalent arsenate(As(v)) in low-level(10ppm) or high-level(100ppm) in drinking-water, and the arsenic exposure have continued to 3 generations. The behavioral development test in the early stage of growth, and Open-field test and T-type water maze test after the growth were carried out the animals in 3 generation(F2). After the behavioral tests, immunological function was tested using lymphocyte of the lien.
We observed different effect of long-term inorganic arsenic exposure for the development of postnatal behavior between As(III) and As(V). Little effects of the As exposure on the behavioral development test of the mouse were observed in the As(III) animals, but delay of development of the reflection and motor function was observed in the As(V) animals. In addition, some effects on the emotional reaction after the growth were also observed in the As exposed animals. It is not known the reason that we obtained different results for their behavior between long term exposure of As(III) and As(V) animals. But, it is necessary to clarify the mechanism for these causes in future.
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