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Analysis of DNA damage by environmental and dietary factors

Research Project

Project/Area Number 14570298
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionMie University

Principal Investigator

OIKAWA Shinji  Mie University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (10277006)

Co-Investigator(Kenkyū-buntansha) KAWANISHI Shosuke  Mie University, Faculty of Medicine, Professor, 医学部, 教授 (10025637)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsdietary factors / environmental factors / cancer risk assessment / reactive oxygen species / reactive nitrogen species / DNA damage / Proteome analysis / Carcinogenic mechanism / カテキン類 / ビスフェノールA / 食品 / 環境化学物質 / 一酸化窒素 / 紫外線
Research Abstract

Reactive oxygen and nitrogen species generated by environmental and dietary factors can cause DNA damage and play important roles in mutagenesis and carcinogenesis. We have investigated sequence specificity of oxidative stress-mediated DNA damage by using 32P-labeled DNA fragments obtained from the human c-Ha-ras-1, p16 and p53 genes. Furthermore, protein expression profile in HL-60 cells treated with an environmental factor was analyzed using two-dimensional gel electrophoresis plus mass spectrometry.
(1) Catechol, a naturally occurring and an important industrial chemical, has been shown to have strong promotion activity and induce glandular stomach tumors to rodent. In addition, catechol is a major metabolite of carcinogenic benzene. Catechol induced oxidative DNA damage in HL-60 cells. Catechol caused damage to 32P-Labeled DNA fragments in the presence of Cu(II). When NADH was added, the DNA damage was markedly enhanced and clearly observed of relatively low concentrations of catech … More ol. Catalase inhibited the DNA damage. Therefore, it is concluded that the oxidative DNA damage by catechol through generation of H2O2 plays an important role in the carcinogenic process of catechol and benzene.
In addition, environmental factors (UVA, benz[a]anthracene, etc), dietary factors (homocysteine, catechins, etc) and medical and pharmaceutical products also induced sequence-specific DNA damage via H2O2 generation.
(2) Bisphenol A (BPA), which has been detected in canned food and human saliva, induced leukemias in rats. A BPA metabolite, 3-hydroxybisphenol A (3-OH-BPA), induced extensive DNA damage in the presence of Cu(II) and NADH. 3-OH-BPA strongly damaged G and C of the ACG sequence complementary to codon 273, a mutational spot of the p53 gene. Furthermore, flow cytometry showed that HL-60 cells treated with BPA underwent apoptotic death. Proteome analysis revealed that four proteins were differentially expressed between control cells and cells treated with BPA. These proteins identified in our proteomic studies may be implicated in carcinogenesis and candidates as tumor biomarkers. Less

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (84 results)

All Other

All Publications (84 results)

  • [Publications] 及川伸二: "カテキン類による酸化的DNA損傷"医学のあゆみ. 208. 688-689 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 坂野克久: "発酵食品に含まれるウレタン代謝物によるDNA損傷の分子機構"磁気共鳴と医学(大和田繁, 吉川敏一 編). 17. 135-138 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S, Kawanishi: "Mechanism of telomere shortening by oxidative stress."Ann.NY Acad.Sci.. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Pinlaor: "Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7, 8-dihydm-2'-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase"Carcinogenesis. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Iwamoto: "DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and a role in its cytotoxic effect"Cancer Sci.. 95. 454-458 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Kobayashi: "Metal-mediated oxidative damage to cellular and isolated DNA by gallic acid, a metabolite of antioxidant propyl gallate"Mutat.Res.. 558. 111-120 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hirakawa: "Photo-irradiated Titanium Dioxide Catalyzes Site Specific DNA Damage via Generation of Hydrogen Peroxide."Free Radic.Res.. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Seike: "Oxidative DNA damage induced by benz[a]anthracene metabolites via redox cycles of quinone and unique non-quinone"Cem.Res.Toxicol.. 16. 1470-1476 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Murata: "Oxidative DNA damage by hyperglycemia-related aldehydes and its marked enhancement by hydrogen peroxide"FEBS Lett.. 554. 138-142 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Oikawa: "Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species"Free Radic.Res.. 37. 881-890 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] A.Furukawa.: "(-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA"Biochem.Pharmacol.. 66. 1769-1778 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Pinlaor: "8-nitroguanine formation in the liver of hamsters infected with Opisthorchis viverrini"Biochem.Biophys.Res.Commun.. 309. 567-571 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Ogawa: "Molecular mechanisms of DNA damage induced by procarbazine in the presence of Cu(II)"Mutat.Res.. 539. 145-155 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Mizutani: "Distinct mechanisms of sit-specific oxidative DNA damage by doxorubicin in the presence of copper(II) and NADPH-cytochrome P450 reductase"Cancer Sci.. 94. 686-691 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Iwamoto: "Oxidativc DNA damage induced by photodegradation products of 3'-azido-3'-deoxythymidine"Arch.Biochem.Biophys.. 416. 155-163 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Oikawa: "Oxidative damage to cellular and isolated DNA by homocysteine : implications for carcinogenesis"Oncogene. 22. 3530-3538 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hirakawa: "Carcinogenic semicarbazide induces sequence-specific DNA damage through the generation of reactive oxygen species and the derived organic radicals"Mutat.Res.. 536. 91-101 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hirakawa: "Sequence-specific DNA damage induced by ultraviolet A-irradiated folic acid via its photolysis product"Arch.Biochem.Biophys.. 410. 261-268 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Himkawa: "Base oxidation at 5' site of GG sequence in double-stranded DNA induced by UVA in the presence of xanthone analogues : relationship between the DNA -damaging abilities of photosensitizers and their HOMO energies"Photochem.Photobiol.. 77. 349-355 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Sakano: "Metabolism of carcinogenic urethane to nitric oxide is involved in oxidative DNA damage"Free Radic.Biol.Med.. 33. 703-714 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Kawanishi: "The role of metals in site-specific DNA damage with reference to carcinogenesis"Free Radic.Biol.Med.. 32. 822-832 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Mizutani: "Mechanism of apoptosis induced by a new topoisomerase inhibitor through the generation of hydrogen peroxide"J.Biol.Chem.. 277. 30684-30689 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Homma-Takeda: "2,4,6-Trinitrotoluene-induced reproductive toxicity via oxidative DNA damage by its metabolite"free Radic.Res.. 36. 555-566 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Oikawa: "Site-specific hydroxylation at polyguanosine in double-stranded DNA by nickel(II) in the presence of SH compounds : comparison with Singlet oxygen-induced DNA damage"Chem.Res.Toxicol.. 15. 1017-1022 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Kawanishi: "Distinct mechanism of oxidative DNA damage induced by carcinogenic nickel subsulfide and nickel oxides"Environ.Health Perspect.. 110, Suppl.5. 789-791 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Hiraku: "Distamycin A, a minor groove binder, changes enediyne-induced DNA cleavage sites and enhances apoptosis"Nucleic Acids Res.. Suppl.2. 95-96 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hirakawa: "Catechol and hydroquinone have different redox properties responsible for their differential DNA-damaging ability"Chem.Res.Toxicol.. 15. 76-82 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 川西正祐: "分子予防環境医学"本の泉社(分子予防環境医学研究会 編). 768 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 及川伸二: "食と生活習慣病"昭和堂(菅原努 監修). 213 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 川西正祐: "中毒学 -基礎・臨床・社会医学-"朝倉書店(荒記俊一 編). 408 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S, Kawanishi: "Mechanism of telomere shortening by oxidative stress."Ann. NY Acad. Sci. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Pinlaor: "Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7, 8-dihydro-2'-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase."Carcinogenesis. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Iwamoto: "DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and a role in its cytotoxic effect."Cancer Sci. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Kobayashi: "Metal-mediated oxidative damage to cellular and isolated DNA by gallic acid, a metabolite of antioxidant propyl gallate."Mutat. Res. 558. 111-120 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hirakawa: "Photo-irradiated Titanium Dioxide Catalyzes Site Specific DNA Damage via Generation of Hydrogen Peroxide."Free Radic. Res. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Seike: "Oxidative DNA damage induced by benz[a]anthracene metabolites via redox cycles of quinone and unique non-quinone."Chem. Res. Toxicol. 16. 1470-1476 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Murata: "Oxidative DNA damage by hyperglycemia-related aldehydes and its marked enhancement by hydrogen peroxide."FEBS Lett. 554. 138-142 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Oikawa: "Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species."Free Radic. Res. 37. 881-890 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] A.Furukawa: "(-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA."Biochem. Pharmacol. 66. 1769-1778 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Pinlaor: "8-nitroguanine formation in the liver of hamsters infected with Opisthorchis viverrini."Biochem. Biophys. Res. Commun. 309. 567-571 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Ogawa: "Molecular mechanisms of DNA damage induced by procarbazine in the presence of Cu(II)"Mutat. Res. 539. 145-155 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Mizutani: "Distinct mechanisms of site-specific oxidative DNA damage by doxorubicin in the presence of copper(II) and NADPH-cytochrome P450 reductase."Cancer Sci. 94. 686-691 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Iwamoto: "Oxidative DNA damage induced by photodegradation products of 3'-azido-3'-deoxythymidine."Arch. Biochem. Biophys. 416. 155-163 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Oikawa: "Oxidative damage to cellular and isolated DNA by homocysteine: implications for carcinogenesis."Oncogene 22. 3530-3538 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hirakawa: "Carcinogenic semicarbazide induces sequence-specific DNA damage through the generation of reactive oxygen species and the derived organic radicals."Mutat. Res. 536. 91-101 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hirakawa: "Sequence-specific DNA damage induced by ultraviolet A-irradiated folic acid via its photolysis product."Arch. Biochem. 410. 261-268 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hirakawa: "Base oxidation at 5' site of GG sequence in double-stranded DNA induced by UVA in the presence of xanthone analogues: relationship between the DNA-damaging abilities of photosensitizers and their HOMO energies."Photochem. Photobiol. 77. 349-355 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Sakano: "Metabolism of carcinogenic urethane to nitric oxide is involved in oxidative DNA damage."Free Radic. Biol. Med. 33. 703-714 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Kawanishi: "The role of metals in site-specific DNA damage with reference to carcinogenesis."Free Radic. Biol. Med. (Review) 32. 822-832 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Mizutani: "Mechanism of apoptosis induced by a new topoisomerase inhibitor through the generation of hydrogen peroxide."J. Biol. Chem. 277. 30684-30689 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Homma-Takeda: "2,4,6-Trinitrotoluene-induced reproductive toxicity via oxidative DNA damage by its metabolite."Free Radic. Res. 36. 555-566 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Oikawa: "Site-specific hydroxylation at polyguanosine in double-stranded DNA by nickel(II) in the presence of SH compounds: comparison with singlet oxygen-induced DNA damage."Chem. Res. Toxicol. 15. 1017-1022 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Kawanishi: "Distinct mechanisms of oxidative DNA damage induced by carcinogenic nickel subsulfide and nickel oxides."Environ. Health Perspect. 110, Suppl. 5. 789-791 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Hiraku: "Distamycin A, a minor groove binder, changes enediyne-induced DNA cleavage sites and enhances apoptosis."Nucleic Acids Res. Suppl. 2. 95-96 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hirakawa: "Catechol and hydroquinone have different redox properties responsible for their differential DNA-damaging ability."Chem. Res. Toxicol. 15. 76-82 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hirakawa: "Photo-irradiated Titanium Dioxide Catalyzes Site Specific DNA Damage via Generation of Hydrogen Peroxide"Free Radic.Res.. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Murata: "Oxidative DNA damage by hyperglycemia-related aldehydes and its marked enhancement by hydrogen peroxide"FEBS Lett.. 554. 138-142 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Seike: "Oxidative DNA damage induced by benz[a]anthracene metabolites via redox cycles of quinone and unique non-quinone"Chem.Res.Toxicol.. 16. 1470-1476 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] A.Furukawa: "(-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA"Biochem.Pharmacol.. 66. 1769-1778 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Pinlaor: "8-nitroguanine formation in the liver of hamsters infected with Opisthorch is viverrini"Biochem.Biophys.Res.Commun.. 309. 567-571 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Ogawa: "Molecular mechanisms of DNA damage induced by procarbazine in the presence of Cu(II)"Mutat.Res.. 539. 145-155 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] H.Mizutani: "Distinct mechanisms of site-specific oxidative DNA damage by doxorubicin in the presence of copper(II) and NADPH-cytochrome P450 reductase"Cancer Sci.. 94. 686-691 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Iwamoto: "Oxidative DNA damage induced by photodegradation products of 3'-azido-3'-deoxythymidine"Arch.Biochem.Biophys.. 416. 155-163 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Oikawa: "Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species"Free Radic.Res.. 37. 881-890 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Oikawa: "Oxidative damage to cellular and isolated DNA by homocysteine : implications for carcinogenesis"Oncogene. 22. 3530-3538 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Hirakawa: "Carcinogenic semicarbazide induces sequence-specific DNA damage through the generation of reactive oxygen species and the derived organic radicals"Mutat.Res. 536. 91-101 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Hirakawa: "Base oxidation at 5' site of GG sequence in double-stranded DNA induced by UVA in the presence of xanthone analogues : Relationship between the DNA-damaging abilities of photosensitizers and their HOMO energies"Photochem.Photobiol.. 77. 349-355 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Hirakawa: "Sequence-Specific DNA Damage Induced by Ultraviolet A-Irradiated Folic Acid via Its Photolysis Product"Arch.Biochem.Biophys.. 410. 261-268 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 及川伸二: "カテキン類による酸化的DNA損傷"医学のあゆみ. 208. 688-689 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 川西正祐: "分子予防環境医学"分子予防環境医学研究会 編. 768 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 及川伸二: "食と生活習慣病"菅原努 監修. 213 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S, Oikawa: "Oxidative damage to cellular and isolated DNA by homocysteine : implications for carcinogenesis"Oncogene. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Hirakawa: "Base Oxidation at 5' Site of GG Sequence in Double-stranded DNA Induced by UVA in the Presence of Xanthone Analogues : Relationship between the DNA-damaging Abilities of Photosensitizers and Their HOMO Energies"Photochem. Photobiol.. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Hirakawa: "Carcinogenic semicarbazide induces sequence-specific DNA damage through the generation of reactive oxygen species and the derived organic radicals"Mutat. Res.. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Hirakawa: "Sequence-specific DNA damage induced by ultraviolet A-irradiated folic acid via its photolysis product"Arch. Biochem. Biophys.. 410. 261-268 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Sakano: "Metabolism of carcinogenic urethane to nitric oxide is involved in oxidative DNA damage"Free Radic. Biol. Med.. 33. 703-714 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Kawanishi: "The role of metals in site-specific DNA damage with reference to carcinogenesis"Free Radic. Biol. Med.. 32. 822-832 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] H.Mizutani: "Mechanism of apoptosis induced by a new topoisomerase inhibitor through the generation of hydrogen peroxide"J. Biol. Chem.. 277. 30684-30689 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Homma-Takeda: "2,4,6-trinitrotoluene-induced reproductive toxicity via oxidative DNA damage by its metabolite"Free Radic. Res.. 36. 555-566 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Oikawa: "Site-specific hydroxylation at polyguanosine in double-stranded DNA by nickel(II) in the presence of SH compounds : comparison with singlet oxygen-induced DNA damage"Chem. Res. Toxicol.. 15. 1017-1022 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Kawanishi: "Distinct mechanisms of oxidative DNA damage induced by carcinogenic nickel subsulfide and nickel oxides"Environ. Health. Perspect.. 110. 789S-791S (2002)

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      2002 Annual Research Report
  • [Publications] K.Hirakawa: "Catechol and Hydroquinone Have Different Redox Properties Responsible for Their Differential DNA-damaging Ability"Chem. Res. Toxicol.. 15. 76-82 (2002)

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      2002 Annual Research Report
  • [Publications] 及川伸二: "食と生活習慣病"昭和堂(菅原努 監修). 213 (2003)

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      2002 Annual Research Report
  • [Publications] 西川正祐: "中毒学-基礎・臨床・社会医学-"朝倉書店(荒記俊一 編). 399 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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