| Project/Area Number |
14570300
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kyushu University |
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Principal Investigator |
KIYOHARA Chikako Kyushu University, Graduate School of Medical Sciences, Assistant Prof., 大学院・医学研究院, 講師 (00169963)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Yoichi Kyushu University, Graduate School of Medical Sciences, Prof., 大学院・医学研究院, 教授 (20172356)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2002: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | lung adenocarcinoma / cytochrome P4502A6 / cytochrome P4502A13 / molecular enidemiology / tobacco stecific N-nitrosamine / 薬物代謝酵素 / 喫煙 / 交互作用 / チトクローム P4502A6 (CYP2A6) / 肺腺がん / CYP2A6遺伝子多型 |
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| Research Abstract |
We examined the relationship between the CYP2A6 and CYP2A13 in Japanese in a case-control study. In this study. we genotyped 179 patients with lung cancer and 96 controls for these two polymorphisms to examine the hypothesis that the variant genotype maybe associated with the risk of lung cancer, particularly adenocarcinoma. No association was observed between the risk of lung cancer and CYP2A6 genotype. According to histological type, compared with one or more copies of the variant allele, the CYP2A13 CC genotype was the most strongly associated with adenocarcinoma (OR=1.67), but this result was compatible with chance [95% confidence interval (CI)=0.37-7.50]. A gene-environment interaction among patients with adenocarcinoma was suggested, with combined the CYP2A13 CC genotype and smoking conferring significantly higher risk (OR=2.80, 95% CI =1.30-6.13), compared to possession at least one copy of the CYP2A13 T allele and non-smoking. These results indicate that CYP2A13 gene and not CYP2A6 may play an important role in the development of lung adenocarcinoma among smokers. Additional studies are warranted to corroborate the smoking-CYP2A13 polymorphism interaction among patients with adenocarcinoma suggested in the present study.
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