| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2004: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2003: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2002: ¥600,000 (Direct Cost: ¥600,000)
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| Research Abstract |
Methicillin-resistant Staphylococci (MRSA and MRC-NS) are recently found in healthy persons who have not been hospitalized; however these bacteria are recognized as one of the most important organisms which cause the nosocomial infectious diseases. In this study, we conducted a survey of MRSA or MRC-NS carriage on 1036 healthy person in the community and 394 healthy carriers were found. The healthy carriers were especially found in the population of children under 6 years old, persons who were treated with antibiotics in recent 6 months, medial workers and their family members. In the medial workers, the ratio of carriers was especially high among pharmacists, and 167 carriers of 215 pharmacists (77.7%) were found. Since the ratio of carriers in non-medial workers was only 25.6%, we further investigated the reason of higher carrier ratio in pharmacists, and found that person who prepares antibiotics as their daily work has the risk to be a carrier.
The MICs (MPIPC) of drug-resistant strains were >64 μg/mL for all the MRSA strains, and approximately 30% of MRC-NS strains. Most of these strains were also resistant against macrolides, quinolones and fosfomycin. The existence of mecA- mecRI mecI gene in drug-resistant strains was also tested by PCR. Most of MESA strains lack only mecI gene, however more the 90% of MRC-NS strains lack mecR1 gene either.
In the near future, the population of aged people and compromised hosts will increase in our community and drug-resistant organisms might cause serious problems. So, it will be important to monitor the tendency of these drug-resistant strains, promote the proper use of antibiotics, and investigate the working environment of pharmacists.
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