| Project/Area Number |
14570320
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Hirosaki University |
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Principal Investigator |
SAITO Hiroshi Hirosaki University, Center for Education and Research of Lifelong Learning, Associate Professor, 生涯学習教育研究センター, 助教授 (70196004)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Colorectal cancer / Fecal occult blood test(FOBT) / Immunochemical FOBT / Guaiac-based FOBT / Sensitivity / 大腸がん検診 |
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| Research Abstract |
This study was conducted to compare sensitivity of immunochemical fecal occult blood test(IFOBT) with that of guaiac FOBT. Subjects were 2858 individuals who underwent colonoscopy as part of a multiphasic health examination and 523 outpatients without bloody stool who underwent colonoscopy at a gastrointestinal unit because of abdominal symptoms. Positive results were obtained in 151 and 338 subjects with IFOBT and FOBT, respectively. Cancer was found in 10 individuals and 6 outpatients.
IFOBT gave positive results in 10 out of 16 patients with colorectal cancer, while guaiac FOBT did 5 out of 16. Sensitivities were calculated to be 63% and 31% for IFOBT and FOBT, respectively. There was no statistically significant difference in sensitivity between the two tests (p=0.08) probably due to a smaller sample size and a lower proportion of first-time screenees (approximately 10%) than those expected at the beginning of this study. IFOBT was suggested to be higher in sensitivities than FOBT, however, a larger sample size will be needed to obtain significant results showing it.
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