| Co-Investigator(Kenkyū-buntansha) |
SUWAZONO Yasushi CHIBA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, ASSISTANT PROFFESOR, 大学院・医学研究院, 助教授 (90302546)
ETSUKO Kobayashi CHIBA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, LECTURER, 大学院・医学研究院, 講師 (80097427)
大久保 靖司 千葉大学, 大学院・医学研究院, 助手 (00301094)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2004: ¥100,000 (Direct Cost: ¥100,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Research Abstract |
Background
Some kinds of lifestyle and work related factors were suggested as the risk factors of diabetes mellitus(DM). Though it is well known that shift work strongly affects on life style, the effect of shift work on DM has not been well studied. Our aim was to assess the effect of shift work on the onset of DM using proportional hazard model.
Methods
7003 male worker aged 19-59 years were followed up from 1992 to 2000. The subjects were classified into five categories according to the changes in job schedule type : daytime workers, shift workers, and other three groups of workers changing job schedule type. The event, which was the onset of DM, was confirmed with the results of health examinations, medical interviews, the sick leave records and the death records. Life table analysis and Cox proportional hazards analysis including age, mean blood pressure, BMI, drinking habit, smoking habit, habitual exercise, the presence of impaired glucose tolerance, and the results of blood chemistries as covariates was performed. Furthermore, Pooled logistic regression analysis was used to adjust for the effect of other potential factors and those variations in every year.
Findings
The incidence rates of DM in daytime and shift work were 1.55 and 2.00/1000 person-years, respectively. Shift workers indicated the highest cumulative incidence rate throughout observation, and the hazard ratio of the onset of DM in shift worker compared with daytime worker was 1.34 and significantly high. The odds ratio of shift work was 1.35 and significant.
Interpretation
The results of this study revealed that shift work independently affected on the onset of DM. This fact suggested that shift work was the risk factor of the onset of DM.
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