| Project/Area Number |
14570332
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | National Hospital Organization Kyoto Medical Center (Clinical Research Institute) (2004-2005)
Kobe University (2002-2003) |
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Principal Investigator |
SAKANE Naoki National Hospital Organization Kyoto Medical Center (Clinical Research Institute), Department of Preventive Medicine, Chief Investigator, 予防医学研究室, 室長 (40335443)
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| Project Period (FY) |
2002 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
|
| Budget Amount *help |
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Life-related disease / Molecular Epidemioology / Behavioral science |
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| Research Abstract |
To prevent the metabolic syndrome, 114 abdominal obesity subjects were screened from 315 subjects in health check up systems. After 3-month's lifestyle intervention based on the behavioral science in 20 abdominal obesity subjects, body weight and serum triglyceride levels were significantly decreased (-3.8kg and -24mg/dl, respectively). After lifestyle intervention, the prevalence of metabolic syndrome was reduced by half. Hyperlipidemic subjects with the Trp64Arg polymorphism in the β3-adrenergic receptor gene, which were associated with decreased resting metabolic rate and lipolysis in white adipose tissue, had difficulties to reduce body weight and serum total cholesterol levels compared with those without the Trp64Arg polymorphism. Hyperlipidemic subjects with the promoter region polymorphism (-3826A/G) in the uncoupling protein 1 gene, which was associated with reduced thermogensis after loading high-gat diets, also had difficulties to reduce body weight and serum total cholestero
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l levels compared with those without this polymorphism. Hyperlipidemic subjects with the D allele in the ACE gene had difficulties to reduce body weight compared those without the D allele, although there was no difference in serum total cholesterol between subjects with or without the D allele. Inversely, hyperlipidemic subjects with Thr54 allele in the fatty acid binding protein 2 gene had difficulties to reduce cholesterol levels compared with the allele, although there was no difference in changes of body weight between subjects with or without the Thr54 allele. To investigate the effects of heredity on body mass index (BMI) and threshold level for salt taste in 41 families. The BMI and serum total cholesterol levels in children was positively correlated with those in the mother, but not significantly associated with those of the father. BMI in children was associated with skipping breakfast and walking hours. Thus, rational and individually tailored therapies may be developed to combat obesity and its associated disorders. Less
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